Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
Lung stereotactic body radiation therapy (SBRT) is associated with sources of geometric uncertainties, such as respiratory motion, daily anatomical variations (anatomical baseline shifts between daily and planned position) and the simultaneous movement between the tumor and the multileaf collimator...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/65036 |
| Acceso en línea: | https://hdl.handle.net/10171/65036 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias Investigacion::Física Lung cancer Radiotherapy Stereotactic body radiation therapy Cáncer de pulmón Radioterapia Radioterapia corporal estereotáctica |
| Sumario: | Lung stereotactic body radiation therapy (SBRT) is associated with sources of geometric uncertainties, such as respiratory motion, daily anatomical variations (anatomical baseline shifts between daily and planned position) and the simultaneous movement between the tumor and the multileaf collimator (the so-called interplay effect) during treatment delivery. In this work, several methodologies have been implemented based on deformable image registration to quantify the dosimetric impact of those geometric uncertainties in lung SBRT. These methodologies revealed two main conclusions: First, daily anatomical deviations in patient anatomy generally had a larger dosimetric impact than respiratory motion. Second, the impact of interplay effect could be a concern for highly irregular patient breathing patterns or for long breathing periods, and whether small field size were used for dose conformation purposes. Furthermore, these methodologies developed would be very helpful for clinicians involved in treatment planning and delivery to evaluate treatment robustness against the geometric uncertainties studied in this work. |
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