Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine wheth...

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Autores: Bonaterra Pastra, Anna, Fernández de Retana, Sofia, Rivas Urbina, Andrea, Puig, Núria, Benítez, Sònia, Pancorbo, Olalla, Rodríguez Luna, David, Pujadas, Francesc, Freijo, Maria del Mar, Tur, Silvia, Martínez Zabaleta, Maite, Cardona Portela, Pere, Vera, Rocío, Lebrato Hernández, Lucia, Arenillas, Juan F., Pérez Sánchez, Soledad, Montaner, Joan, Sánchez Quesada, Jose Luis, Hernández Guillamon, Mar
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173903
Acesso em linha:https://hdl.handle.net/2445/173903
Access Level:acceso abierto
Palavra-chave:Malaltia d'Alzheimer
Lipoproteïnes
Amiloïdosi
Alzheimer's disease
Lipoproteins
Amyloidosis
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spelling Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s DiseaseBonaterra Pastra, AnnaFernández de Retana, SofiaRivas Urbina, AndreaPuig, NúriaBenítez, SòniaPancorbo, OlallaRodríguez Luna, DavidPujadas, FrancescFreijo, Maria del MarTur, SilviaMartínez Zabaleta, MaiteCardona Portela, PereVera, RocíoLebrato Hernández, LuciaArenillas, Juan F.Pérez Sánchez, SoledadMontaner, JoanSánchez Quesada, Jose LuisHernández Guillamon, MarMalaltia d'AlzheimerLipoproteïnesAmiloïdosiAlzheimer's diseaseLipoproteinsAmyloidosisCerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.MDPI AG2021202120212021info:eu-repo/semantics/article14 p.application/pdfhttps://hdl.handle.net/2445/173903Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/biomedicines9010072Biomedicines, 2021, vol. 9 (1), num. 72https://doi.org/10.3390/biomedicines9010072cc by (c) Bonaterra Pastra, Anna et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1739032026-05-29T05:05:01Z
dc.title.none.fl_str_mv Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
title Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
spellingShingle Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
Bonaterra Pastra, Anna
Malaltia d'Alzheimer
Lipoproteïnes
Amiloïdosi
Alzheimer's disease
Lipoproteins
Amyloidosis
title_short Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
title_full Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
title_fullStr Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
title_full_unstemmed Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
title_sort Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
dc.creator.none.fl_str_mv Bonaterra Pastra, Anna
Fernández de Retana, Sofia
Rivas Urbina, Andrea
Puig, Núria
Benítez, Sònia
Pancorbo, Olalla
Rodríguez Luna, David
Pujadas, Francesc
Freijo, Maria del Mar
Tur, Silvia
Martínez Zabaleta, Maite
Cardona Portela, Pere
Vera, Rocío
Lebrato Hernández, Lucia
Arenillas, Juan F.
Pérez Sánchez, Soledad
Montaner, Joan
Sánchez Quesada, Jose Luis
Hernández Guillamon, Mar
author Bonaterra Pastra, Anna
author_facet Bonaterra Pastra, Anna
Fernández de Retana, Sofia
Rivas Urbina, Andrea
Puig, Núria
Benítez, Sònia
Pancorbo, Olalla
Rodríguez Luna, David
Pujadas, Francesc
Freijo, Maria del Mar
Tur, Silvia
Martínez Zabaleta, Maite
Cardona Portela, Pere
Vera, Rocío
Lebrato Hernández, Lucia
Arenillas, Juan F.
Pérez Sánchez, Soledad
Montaner, Joan
Sánchez Quesada, Jose Luis
Hernández Guillamon, Mar
author_role author
author2 Fernández de Retana, Sofia
Rivas Urbina, Andrea
Puig, Núria
Benítez, Sònia
Pancorbo, Olalla
Rodríguez Luna, David
Pujadas, Francesc
Freijo, Maria del Mar
Tur, Silvia
Martínez Zabaleta, Maite
Cardona Portela, Pere
Vera, Rocío
Lebrato Hernández, Lucia
Arenillas, Juan F.
Pérez Sánchez, Soledad
Montaner, Joan
Sánchez Quesada, Jose Luis
Hernández Guillamon, Mar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Lipoproteïnes
Amiloïdosi
Alzheimer's disease
Lipoproteins
Amyloidosis
topic Malaltia d'Alzheimer
Lipoproteïnes
Amiloïdosi
Alzheimer's disease
Lipoproteins
Amyloidosis
description Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173903
url https://hdl.handle.net/2445/173903
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/biomedicines9010072
Biomedicines, 2021, vol. 9 (1), num. 72
https://doi.org/10.3390/biomedicines9010072
dc.rights.none.fl_str_mv cc by (c) Bonaterra Pastra, Anna et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Bonaterra Pastra, Anna et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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