Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine wheth...

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Detalhes bibliográficos
Autores: Bonaterra Pastra, Anna, Fernández de Retana, Sofia, Rivas Urbina, Andrea, Puig, Núria, Benítez, Sònia, Pancorbo, Olalla, Rodríguez Luna, David, Pujadas, Francesc, Freijo, Maria del Mar, Tur, Silvia, Martínez Zabaleta, Maite, Cardona Portela, Pere, Vera, Rocío, Lebrato Hernández, Lucia, Arenillas, Juan F., Pérez Sánchez, Soledad, Montaner, Joan, Sánchez Quesada, Jose Luis, Hernández Guillamon, Mar
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173903
Acesso em linha:https://hdl.handle.net/2445/173903
Access Level:Acceso aberto
Palavra-chave:Malaltia d'Alzheimer
Lipoproteïnes
Amiloïdosi
Alzheimer's disease
Lipoproteins
Amyloidosis
Descrição
Resumo:Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.

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