Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort

Jesús, Silvia; Labrador Espinosa, Miguel A.; Adarmes Gómez, Astrid D.; Méndel del Barrio, C.; Martínez Castrillo, Juan Carlos; Alonso Cánovas, Araceli; Sánchez Alonso, Pilar; Novo Pontes, Sabela; Alonso Losada, María Gema; López Ariztegui, Nuria; Segundo Rodríguez, José Clemente; Morales, M. I.; Gastón, Itziar; Lacruz Bescos, F.; Clavero Ibarra, Pedro; Kulisevsky Bojarsky, Jaume; Pagonabarraga, Javier; Pascual Sedano, Berta; Martínez Martín, Pablo; Santos García, Diego; Mir, Pablo; Cubo Delgado, Esther; COPPADIS Study Group

Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort

The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patient...

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Autores:	Jesús, Silvia, Labrador Espinosa, Miguel A., Adarmes Gómez, Astrid D., Méndel del Barrio, C., Martínez Castrillo, Juan Carlos, Alonso Cánovas, Araceli, Sánchez Alonso, Pilar, Novo Pontes, Sabela, Alonso Losada, María Gema, López Ariztegui, Nuria, Segundo Rodríguez, José Clemente, Morales, M. I., Gastón, Itziar, Lacruz Bescos, F., Clavero Ibarra, Pedro, Kulisevsky Bojarsky, Jaume, Pagonabarraga, Javier, Pascual Sedano, Berta, Martínez Martín, Pablo, Santos García, Diego, Mir, Pablo, Cubo Delgado, Esther, COPPADIS Study Group
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2020
País:	España
Institución:	Universidad de Burgos (UBU)
Repositorio:	Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:	oai:riubu.ubu.es:10259/8793
Acceso en línea:	http://hdl.handle.net/10259/8793
Access Level:	acceso abierto
Palabra clave:	Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology

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spelling	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohortJesús, SilviaLabrador Espinosa, Miguel A.Adarmes Gómez, Astrid D.Méndel del Barrio, C.Martínez Castrillo, Juan CarlosAlonso Cánovas, AraceliSánchez Alonso, PilarNovo Pontes, SabelaAlonso Losada, María GemaLópez Ariztegui, NuriaSegundo Rodríguez, José ClementeMorales, M. I.Gastón, ItziarLacruz Bescos, F.Clavero Ibarra, PedroKulisevsky Bojarsky, JaumePagonabarraga, JavierPascual Sedano, BertaMartínez Martín, PabloSantos García, DiegoMir, PabloCubo Delgado, EstherCOPPADIS Study GroupSistema nervioso-EnfermedadesMedicinaNeurologíaNervous system-DiseasesMedicineNeurologyThe study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.Springer Nature202420242020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10259/8793reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésScientific Reports. 2020, V. 10, n. 1https://doi.org/10.1038/s41598-020-73756-zAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/87932026-05-28T07:56:11Z
dc.title.none.fl_str_mv	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
spellingShingle	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort Jesús, Silvia Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
title_short	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title_full	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title_fullStr	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title_full_unstemmed	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title_sort	Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
dc.creator.none.fl_str_mv	Jesús, Silvia Labrador Espinosa, Miguel A. Adarmes Gómez, Astrid D. Méndel del Barrio, C. Martínez Castrillo, Juan Carlos Alonso Cánovas, Araceli Sánchez Alonso, Pilar Novo Pontes, Sabela Alonso Losada, María Gema López Ariztegui, Nuria Segundo Rodríguez, José Clemente Morales, M. I. Gastón, Itziar Lacruz Bescos, F. Clavero Ibarra, Pedro Kulisevsky Bojarsky, Jaume Pagonabarraga, Javier Pascual Sedano, Berta Martínez Martín, Pablo Santos García, Diego Mir, Pablo Cubo Delgado, Esther COPPADIS Study Group
author	Jesús, Silvia
author_facet	Jesús, Silvia Labrador Espinosa, Miguel A. Adarmes Gómez, Astrid D. Méndel del Barrio, C. Martínez Castrillo, Juan Carlos Alonso Cánovas, Araceli Sánchez Alonso, Pilar Novo Pontes, Sabela Alonso Losada, María Gema López Ariztegui, Nuria Segundo Rodríguez, José Clemente Morales, M. I. Gastón, Itziar Lacruz Bescos, F. Clavero Ibarra, Pedro Kulisevsky Bojarsky, Jaume Pagonabarraga, Javier Pascual Sedano, Berta Martínez Martín, Pablo Santos García, Diego Mir, Pablo Cubo Delgado, Esther COPPADIS Study Group
author_role	author
author2	Labrador Espinosa, Miguel A. Adarmes Gómez, Astrid D. Méndel del Barrio, C. Martínez Castrillo, Juan Carlos Alonso Cánovas, Araceli Sánchez Alonso, Pilar Novo Pontes, Sabela Alonso Losada, María Gema López Ariztegui, Nuria Segundo Rodríguez, José Clemente Morales, M. I. Gastón, Itziar Lacruz Bescos, F. Clavero Ibarra, Pedro Kulisevsky Bojarsky, Jaume Pagonabarraga, Javier Pascual Sedano, Berta Martínez Martín, Pablo Santos García, Diego Mir, Pablo Cubo Delgado, Esther COPPADIS Study Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
topic	Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
description	The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.
publishDate	2020
dc.date.none.fl_str_mv	2020 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10259/8793
url	http://hdl.handle.net/10259/8793
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Scientific Reports. 2020, V. 10, n. 1 https://doi.org/10.1038/s41598-020-73756-z
dc.rights.none.fl_str_mv	Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Springer Nature
publisher.none.fl_str_mv	Springer Nature
dc.source.none.fl_str_mv	reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU) instname:Universidad de Burgos (UBU)
instname_str	Universidad de Burgos (UBU)
reponame_str	Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection	Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort

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