Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours

The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD pa...

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Autores: Jesús, Silvia, Labrador-Espinosa, Miguel A.|||0000-0003-3576-1777, Adarmes-Gómez, A.D.|||0000-0002-1337-9289, Méndez-del Barrio, Carlota, Martínez-Castrillo, Juan Carlos|||0000-0001-7744-6850, Alonso-Cánovas, Araceli|||0000-0003-1702-2655, Sánchez Alonso, Pilar|||0000-0003-0496-4707, Novo-Ponte, Sabela, Alonso-Losada, Maria Gema, López Ariztegui, Nuria|||0000-0001-7172-3191, Segundo Rodríguez, José C., Morales, M.I., Gastón, Itziar, Lacruz Bescos, Francisco, Clavero Ibarra, Pedro, Kulisevsky, Jaime|||0000-0003-4870-1431, Pagonabarraga Mora, Javier|||0000-0002-3248-704X, Pascual Sedano, Berta María|||0000-0002-9298-8241, Martinez-Martin, Pablo|||0000-0003-0837-5280, Santos García, Diego|||0000-0002-3126-5111, Mir, Pablo|||0000-0003-1656-302X, Aguilar Barberà, Miquel, Almeria, Marta|||0000-0001-7445-6113, Álvarez Sauco, María, Arnáiz, Sandra, Arribas, Sonia, Ascunce Vidondo, Arancha, Bernardo Lambrich, Noemí, Bejr-kasem, Helena|||0000-0001-8828-5976, Blázquez Estrada, Marta|||0000-0003-3348-9992, Botí, M.|||0000-0003-2963-6929, Borrué, Carmen, Cabello González, Carolina, Cámara Lorenzo, Ana, Carrillo, Fátima, Carrillo Padilla, Francisco, Casas, Elena, Catalán Alonso, Maria José, Cortina Fernández, Ana, Cots-Foraster, Anna|||0000-0002-9169-7653, Crespo Cuevas, Ane Miren|||0000-0003-1400-5809, Cubo, Esther|||0000-0003-0018-1182, Diez-Fairen, Monica|||0000-0003-1882-0309, Escalante, Sonia|||0000-0001-8931-1400, Erro, Elena, Fàbregues-Boixar i Nebot, Oriol de|||0000-0002-3518-5338, Fernández Guillán, Noelia, Gámez, Pedro, Gallego, Miguel|||0000-0002-8882-4033, García Caldentey, Juan, García Campos, Cristina|||0000-0003-3277-2374, García Moreno, José Manuel, Gómez Garre, María P., González Aloy, Javier, González Ardura, Jessica, González García, Beatriz, González Palmás, María J., González Toledo, G.R., Golpe Díaz, Ana, Grau Solá, Mireia, Guardia, Gemma, Horta-Barba, Andrea|||0000-0003-0050-5466, Infante, Jon|||0000-0003-4025-4606, Kurtis, Mónica|||0000-0003-3037-9712, Hernández-Vara, Jorge|||0000-0002-9129-5224, Labandeira, Carmen, Lage Castro, Melva, Legarda, Inés, López Díaz, Luis M., López Manzanares, Lydia|||0000-0003-4615-4542, López Seoane, Balbino, Macías, Yolanda, Mata, Marina|||0000-0001-9693-7663, Martí Andres, Gloria, Martí, María J., McAfee, Darrian, Meitín, Maria T., Menéndez González, Manuel, Miranda Santiago, Javier, Moreno Diéguez, Antonio, Nogueira, Víctor, Novo Amado, Alba, Ordás Bandera, Carlos Manuel|||0000-0003-3551-8769, Pastor, Pau|||0000-0002-7493-8777, Paz González, José M., Pareés, Isabel|||0000-0002-6873-4823, Pérez Fuertes, Aída, Pérez Noguera, Rafael, Planellas, Lluis|||0000-0002-0769-6675, Prats, M. A., Prieto Jurczynska, Cristina, Pueyo Morlans, Mercedes, Puente, Víctor, Redondo Rafales, Nuria, Rodríguez Méndez, Luisa, Rodríguez Pérez, A. B., Roldán, Florinda, De Arcos, M.R., Ruíz Martínez, J., Sánchez-Carpintero, Macarena, Sánchez Díez, Gemma, Sánchez Rodríguez, Antonio, Santacruz, Pilar, Seijo, Manuel, Serarols, A., Sierra Peña, María, Solano Vila, Berta|||0009-0007-8945-0487, Suárez Castro, Ester, Tartari, Juan Pablo, Valero, Caridad, Vargas, Laura, Vázquez Gómez, R., Vela, Lydia|||0000-0001-6663-395X, Villanueva, Clara, Vives-Pastor, Bárbara, Villar, Maria Dolores
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:283877
Acceso en línea:https://ddd.uab.cat/record/283877
https://dx.doi.org/urn:doi:10.1038/s41598-020-73756-z
Access Level:acceso abierto
Palabra clave:Neurological disorders
Neurology
Descripción
Sumario:The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.

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