Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort
Background: Urothelial carcinoma (UC) is the predominant (95%) bladder cancer subtype in industrialised nations. Animal and epidemiological human studies suggest that hormonal factors may influence UC risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigat...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versión aceptada para publicación |
| Data de publicação: | 2020 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/163000 |
| Acesso em linha: | https://hdl.handle.net/2445/163000 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Càncer de bufeta Menstruació Hormones Bladder cancer Menstruation |
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Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohortLuján Barroso, LeilaBotteri, EdoardoCaini, SaverioLjungberg, BörjeRoswall, NinaTjønneland, AnneBueno de Mesquita, H. BasGram, Inger T.Tumino, RosarioKiemeney, Lambertus A. L. M.Liedberg, FredrikStocks, TanjaGunter, Marc J.Murphy, NeilCervenka, IrisFournier, AgnèsKvaskoff, MarinaHäggström, ChristelOvervad, KimLund, EilivWaaseth, MaritFortner, Renée T.Kühn, TilmanMenéndez, VirginiaSánchez, María JoséSantiuste, CarmenPérez Cornago, AuroraZamora-Ros, RaulCross, Amanda J.Trichopoulou, AntoniaKarakatsani, AnnaPeppa, EleniPalli, DomenicoKrogh, VittorioSciannameo, VeronicaMattiello, AmaliaPanico, Salvatorevan Gils, Carla H.Onland-Moret, N. CharlotteBarricarte, AurelioAmiano, PilarKhaw, Kay-TeeBoeing, HeinerWeiderpass, ElisabeteDuell, Eric J.Càncer de bufetaMenstruacióHormonesBladder cancerMenstruationHormonesBackground: Urothelial carcinoma (UC) is the predominant (95%) bladder cancer subtype in industrialised nations. Animal and epidemiological human studies suggest that hormonal factors may influence UC risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort (EPIC). Associations between hormonal factors and incident UC (overall and by tumour grade, by tumour aggressiveness, and by non-muscle invasive UC) risk were evaluated using Cox proportional hazards models. All models were stratified by age at recruitment and study centre, and adjusted for smoking status and intensity, and fruit and vegetable intakes. Results: During a mean of 15 years of follow-up, 529 women developed UC. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT) showed an inverse association between, number of FTP was inversely associated with UC risk (HR≥5vs1=0.48, 0.25-0.90; P-trend in parous women=0.010) and MHT-use (compared to non-use) was positively associated with UC risk (HR=1.27, 1.03-1.57), but no dose-response by years of MHT-use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analysis in never-smokers showed similar HR patterns for number of FTP and no association between MHT-use and UC risk. Association between MHT-use and UC risk only remained significant in current-smokers. No heterogeneity of the risk estimations in the final model was observed by tumour aggressiveness or by tumour grade. A positive association between the MTH-use and non-muscle invasive UC risk was observed. Conclusion: Increasing number of FTP may reduce UC risk. Our results provided limited evidence for a role of MHT-use in UC risk due to residual confounding by tobacco. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.American Association for Cancer Research (AACR)2020202120202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion41 p.application/pdfhttps://hdl.handle.net/2445/163000Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1158/1055-9965.EPI-20-0184Cancer Epidemiology Biomarkers & Prevention, 2020, p. 1-30https://doi.org/10.1158/1055-9965.EPI-20-0184(c) American Association for Cancer Research (AACR), 2020info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1630002026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort |
| title |
Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort |
| spellingShingle |
Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort Luján Barroso, Leila Càncer de bufeta Menstruació Hormones Bladder cancer Menstruation Hormones |
| title_short |
Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort |
| title_full |
Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort |
| title_fullStr |
Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort |
| title_full_unstemmed |
Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort |
| title_sort |
Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort |
| dc.creator.none.fl_str_mv |
Luján Barroso, Leila Botteri, Edoardo Caini, Saverio Ljungberg, Börje Roswall, Nina Tjønneland, Anne Bueno de Mesquita, H. Bas Gram, Inger T. Tumino, Rosario Kiemeney, Lambertus A. L. M. Liedberg, Fredrik Stocks, Tanja Gunter, Marc J. Murphy, Neil Cervenka, Iris Fournier, Agnès Kvaskoff, Marina Häggström, Christel Overvad, Kim Lund, Eiliv Waaseth, Marit Fortner, Renée T. Kühn, Tilman Menéndez, Virginia Sánchez, María José Santiuste, Carmen Pérez Cornago, Aurora Zamora-Ros, Raul Cross, Amanda J. Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Palli, Domenico Krogh, Vittorio Sciannameo, Veronica Mattiello, Amalia Panico, Salvatore van Gils, Carla H. Onland-Moret, N. Charlotte Barricarte, Aurelio Amiano, Pilar Khaw, Kay-Tee Boeing, Heiner Weiderpass, Elisabete Duell, Eric J. |
| author |
Luján Barroso, Leila |
| author_facet |
Luján Barroso, Leila Botteri, Edoardo Caini, Saverio Ljungberg, Börje Roswall, Nina Tjønneland, Anne Bueno de Mesquita, H. Bas Gram, Inger T. Tumino, Rosario Kiemeney, Lambertus A. L. M. Liedberg, Fredrik Stocks, Tanja Gunter, Marc J. Murphy, Neil Cervenka, Iris Fournier, Agnès Kvaskoff, Marina Häggström, Christel Overvad, Kim Lund, Eiliv Waaseth, Marit Fortner, Renée T. Kühn, Tilman Menéndez, Virginia Sánchez, María José Santiuste, Carmen Pérez Cornago, Aurora Zamora-Ros, Raul Cross, Amanda J. Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Palli, Domenico Krogh, Vittorio Sciannameo, Veronica Mattiello, Amalia Panico, Salvatore van Gils, Carla H. Onland-Moret, N. Charlotte Barricarte, Aurelio Amiano, Pilar Khaw, Kay-Tee Boeing, Heiner Weiderpass, Elisabete Duell, Eric J. |
| author_role |
author |
| author2 |
Botteri, Edoardo Caini, Saverio Ljungberg, Börje Roswall, Nina Tjønneland, Anne Bueno de Mesquita, H. Bas Gram, Inger T. Tumino, Rosario Kiemeney, Lambertus A. L. M. Liedberg, Fredrik Stocks, Tanja Gunter, Marc J. Murphy, Neil Cervenka, Iris Fournier, Agnès Kvaskoff, Marina Häggström, Christel Overvad, Kim Lund, Eiliv Waaseth, Marit Fortner, Renée T. Kühn, Tilman Menéndez, Virginia Sánchez, María José Santiuste, Carmen Pérez Cornago, Aurora Zamora-Ros, Raul Cross, Amanda J. Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Palli, Domenico Krogh, Vittorio Sciannameo, Veronica Mattiello, Amalia Panico, Salvatore van Gils, Carla H. Onland-Moret, N. Charlotte Barricarte, Aurelio Amiano, Pilar Khaw, Kay-Tee Boeing, Heiner Weiderpass, Elisabete Duell, Eric J. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Càncer de bufeta Menstruació Hormones Bladder cancer Menstruation Hormones |
| topic |
Càncer de bufeta Menstruació Hormones Bladder cancer Menstruation Hormones |
| description |
Background: Urothelial carcinoma (UC) is the predominant (95%) bladder cancer subtype in industrialised nations. Animal and epidemiological human studies suggest that hormonal factors may influence UC risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort (EPIC). Associations between hormonal factors and incident UC (overall and by tumour grade, by tumour aggressiveness, and by non-muscle invasive UC) risk were evaluated using Cox proportional hazards models. All models were stratified by age at recruitment and study centre, and adjusted for smoking status and intensity, and fruit and vegetable intakes. Results: During a mean of 15 years of follow-up, 529 women developed UC. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT) showed an inverse association between, number of FTP was inversely associated with UC risk (HR≥5vs1=0.48, 0.25-0.90; P-trend in parous women=0.010) and MHT-use (compared to non-use) was positively associated with UC risk (HR=1.27, 1.03-1.57), but no dose-response by years of MHT-use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analysis in never-smokers showed similar HR patterns for number of FTP and no association between MHT-use and UC risk. Association between MHT-use and UC risk only remained significant in current-smokers. No heterogeneity of the risk estimations in the final model was observed by tumour aggressiveness or by tumour grade. A positive association between the MTH-use and non-muscle invasive UC risk was observed. Conclusion: Increasing number of FTP may reduce UC risk. Our results provided limited evidence for a role of MHT-use in UC risk due to residual confounding by tobacco. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020 2020 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/163000 |
| url |
https://hdl.handle.net/2445/163000 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1158/1055-9965.EPI-20-0184 Cancer Epidemiology Biomarkers & Prevention, 2020, p. 1-30 https://doi.org/10.1158/1055-9965.EPI-20-0184 |
| dc.rights.none.fl_str_mv |
(c) American Association for Cancer Research (AACR), 2020 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) American Association for Cancer Research (AACR), 2020 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
41 p. application/pdf |
| dc.publisher.none.fl_str_mv |
American Association for Cancer Research (AACR) |
| publisher.none.fl_str_mv |
American Association for Cancer Research (AACR) |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
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|
| repository.mail.fl_str_mv |
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1869404287330680832 |
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15,81155 |