Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort

Background: Urothelial carcinoma (UC) is the predominant (95%) bladder cancer subtype in industrialised nations. Animal and epidemiological human studies suggest that hormonal factors may influence UC risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigat...

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Autores: Luján Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Börje, Roswall, Nina, Tjønneland, Anne, Bueno de Mesquita, H. Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A. L. M., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnès, Kvaskoff, Marina, Häggström, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Fortner, Renée T., Kühn, Tilman, Menéndez, Virginia, Sánchez, María José, Santiuste, Carmen, Pérez Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, Duell, Eric J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/163000
Acceso en línea:https://hdl.handle.net/2445/163000
Access Level:acceso abierto
Palabra clave:Càncer de bufeta
Menstruació
Hormones
Bladder cancer
Menstruation
Descripción
Sumario:Background: Urothelial carcinoma (UC) is the predominant (95%) bladder cancer subtype in industrialised nations. Animal and epidemiological human studies suggest that hormonal factors may influence UC risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort (EPIC). Associations between hormonal factors and incident UC (overall and by tumour grade, by tumour aggressiveness, and by non-muscle invasive UC) risk were evaluated using Cox proportional hazards models. All models were stratified by age at recruitment and study centre, and adjusted for smoking status and intensity, and fruit and vegetable intakes. Results: During a mean of 15 years of follow-up, 529 women developed UC. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT) showed an inverse association between, number of FTP was inversely associated with UC risk (HR≥5vs1=0.48, 0.25-0.90; P-trend in parous women=0.010) and MHT-use (compared to non-use) was positively associated with UC risk (HR=1.27, 1.03-1.57), but no dose-response by years of MHT-use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analysis in never-smokers showed similar HR patterns for number of FTP and no association between MHT-use and UC risk. Association between MHT-use and UC risk only remained significant in current-smokers. No heterogeneity of the risk estimations in the final model was observed by tumour aggressiveness or by tumour grade. A positive association between the MTH-use and non-muscle invasive UC risk was observed. Conclusion: Increasing number of FTP may reduce UC risk. Our results provided limited evidence for a role of MHT-use in UC risk due to residual confounding by tobacco. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.

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