Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines

The protection induced by vaccines against infectious diseases such as malaria, dengue or hepatitis relies on a the creation of immune memory by T cells, key components of the human immune system. The induction of a strong T cell response leading to long lasting memory can be improved by using prime...

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Detalhes bibliográficos
Autores: Fernández Arias, Clemente, Herrero, Miguel Angel, Bertocchini, Federica, Acosta Salmerón, Francisco Javier, Fernández Arias, Cristina
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8078
Acesso em linha:https://hdl.handle.net/20.500.14352/8078
Access Level:acceso abierto
Palavra-chave:577.27
576.32
T cells
Immunodominance
Population mechanics
Prime-boost vaccines
Inmunología
Biología celular (Biología)
Biología molecular (Biología)
2412 Inmunología
2407 Biología Celular
2415 Biología Molecular
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oai_identifier_str oai:docta.ucm.es:20.500.14352/8078
network_acronym_str ES
network_name_str España
repository_id_str
spelling Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccinesFernández Arias, ClementeHerrero, Miguel AngelBertocchini, FedericaAcosta Salmerón, Francisco JavierFernández Arias, Cristina577.27576.32T cellsImmunodominancePopulation mechanicsPrime-boost vaccinesInmunologíaBiología celular (Biología)Biología molecular (Biología)2412 Inmunología2407 Biología Celular2415 Biología MolecularThe protection induced by vaccines against infectious diseases such as malaria, dengue or hepatitis relies on a the creation of immune memory by T cells, key components of the human immune system. The induction of a strong T cell response leading to long lasting memory can be improved by using prime-boost (PB) vaccines, which consist in successive inoculations of appropriate vectors carrying target antigens that can be recognized by specific T cell clones. A problem faced by PB vaccines is the fact that T cell response is often biased towards a few clones that can identify only a small set of antigens, out of the many that could be displayed by the pathogen. This phenomenon, known as immunodominance, can significantly compromise the effectiveness of vaccination. In this work we will use mathematical modeling to better understand the role of T cell population dynamics in the onset of immunodominance in PB vaccines. In particular, we will use mathematical analysis and simulations to compare single-dose vaccines with PB ones, both for homologous (where the same antigen is used in every shot) and heterologous protocols (in which different antigens are used at each step).MDPIUniversidad Complutense de Madrid20202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8078reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/80782026-06-02T12:44:21Z
dc.title.none.fl_str_mv Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines
title Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines
spellingShingle Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines
Fernández Arias, Clemente
577.27
576.32
T cells
Immunodominance
Population mechanics
Prime-boost vaccines
Inmunología
Biología celular (Biología)
Biología molecular (Biología)
2412 Inmunología
2407 Biología Celular
2415 Biología Molecular
title_short Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines
title_full Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines
title_fullStr Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines
title_full_unstemmed Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines
title_sort Modeling the dependence of immunodominance on T Cell dynamics in prime-boost vaccines
dc.creator.none.fl_str_mv Fernández Arias, Clemente
Herrero, Miguel Angel
Bertocchini, Federica
Acosta Salmerón, Francisco Javier
Fernández Arias, Cristina
author Fernández Arias, Clemente
author_facet Fernández Arias, Clemente
Herrero, Miguel Angel
Bertocchini, Federica
Acosta Salmerón, Francisco Javier
Fernández Arias, Cristina
author_role author
author2 Herrero, Miguel Angel
Bertocchini, Federica
Acosta Salmerón, Francisco Javier
Fernández Arias, Cristina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.27
576.32
T cells
Immunodominance
Population mechanics
Prime-boost vaccines
Inmunología
Biología celular (Biología)
Biología molecular (Biología)
2412 Inmunología
2407 Biología Celular
2415 Biología Molecular
topic 577.27
576.32
T cells
Immunodominance
Population mechanics
Prime-boost vaccines
Inmunología
Biología celular (Biología)
Biología molecular (Biología)
2412 Inmunología
2407 Biología Celular
2415 Biología Molecular
description The protection induced by vaccines against infectious diseases such as malaria, dengue or hepatitis relies on a the creation of immune memory by T cells, key components of the human immune system. The induction of a strong T cell response leading to long lasting memory can be improved by using prime-boost (PB) vaccines, which consist in successive inoculations of appropriate vectors carrying target antigens that can be recognized by specific T cell clones. A problem faced by PB vaccines is the fact that T cell response is often biased towards a few clones that can identify only a small set of antigens, out of the many that could be displayed by the pathogen. This phenomenon, known as immunodominance, can significantly compromise the effectiveness of vaccination. In this work we will use mathematical modeling to better understand the role of T cell population dynamics in the onset of immunodominance in PB vaccines. In particular, we will use mathematical analysis and simulations to compare single-dose vaccines with PB ones, both for homologous (where the same antigen is used in every shot) and heterologous protocols (in which different antigens are used at each step).
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8078
url https://hdl.handle.net/20.500.14352/8078
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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