Alzheimer’s disease: a continuum with visual involvements

Introduction: Alzheimer’s disease (AD) is the most common form of dementia affecting the central nervous system, and alteration of several visual structures has been reported. Structural retinal changes are usually accompanied by changes in visual function in this disease. The aim of this study was...

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Autores: Elvira Hurtado, Lorena, López Cuenca, Inés, Hoz Montañana, María Rosa De, Salas, Mario, Sánchez-Puebla Fernández, Lidia, Ramírez Toraño, Federico, Matamoros, José Antonio, Fernández Albarral, José, Rojas Lozano, María Del Pilar, Alfonsín, Soraya, Delgado Losada, María Luisa, Ramírez, Ana I., Salazar Corral, Juan José, Maestu Unturbe, Fernando, Gil Gregorio, Pedro, Ramírez Sebastián, José Manuel, García Martín, Elena Salobrar
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/87405
Acesso em linha:https://hdl.handle.net/20.500.14352/87405
Access Level:acceso abierto
Palavra-chave:616.894-053.9
617.735-07
Alzheimer’s disease, mild cognitive impairment, family history, visual function, visual acuity, contrast sensitivity, PDT
Neurociencias (Medicina)
Oftalmología
2490 Neurociencias
3201.09 Oftalmología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/87405
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spelling Alzheimer’s disease: a continuum with visual involvementsElvira Hurtado, LorenaLópez Cuenca, InésHoz Montañana, María Rosa DeSalas, MarioSánchez-Puebla Fernández, LidiaRamírez Toraño, FedericoMatamoros, José AntonioFernández Albarral, JoséRojas Lozano, María Del PilarAlfonsín, SorayaDelgado Losada, María LuisaRamírez, Ana I.Salazar Corral, Juan JoséMaestu Unturbe, FernandoGil Gregorio, PedroRamírez Sebastián, José ManuelGarcía Martín, Elena Salobrar616.894-053.9617.735-07Alzheimer’s disease, mild cognitive impairment, family history, visual function, visual acuity, contrast sensitivity, PDTNeurociencias (Medicina)Oftalmología2490 Neurociencias3201.09 OftalmologíaIntroduction: Alzheimer’s disease (AD) is the most common form of dementia affecting the central nervous system, and alteration of several visual structures has been reported. Structural retinal changes are usually accompanied by changes in visual function in this disease. The aim of this study was to analyse the differences in visual function at different stages of the pathology (family history group (FH+), mild cognitive impairment (MCI), mild AD and moderate AD) in comparison with a control group of subjects with no cognitive decline and no family history of AD. Methods: We included 53 controls, 13 subjects with FH+, 23 patients with MCI, 25 patients with mild AD and, 21 patients with moderate AD. All were ophthalmologically healthy. Visual acuity (VA), contrast sensitivity (CS), colour perception, visual integration, and fundus examination were performed. Results: The analysis showed a statistically significant decrease in VA, CS and visual integration score between the MCI, mild AD and moderate AD groups compared to the control group. In the CS higher frequencies and in the colour perception test (total errors number), statistically significant differences were also observed in the MCI, mild AD and moderate AD groups with respect to the FH+ group and also between the control and AD groups. The FH+ group showed no statistically significant difference in visual functions compared to the control group. All the test correlated with the Mini Mental State Examination score and showed good predictive value when memory decline was present, with better values when AD was at a more advanced stage. Conclusion: Alterations in visual function appear in subjects with MCI and evolve when AD is established, being stable in the initial stages of the disease (mild AD and moderate AD). Therefore, visual psychophysical tests are a useful, simple and complementary tool to neuropsychological tests to facilitate diagnosis in the preclinical and early stages of AD.Frontiers MediaUniversidad Complutense de Madrid20232023-07-0620232023-07-06journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/87405reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/874052026-06-02T12:44:21Z
dc.title.none.fl_str_mv Alzheimer’s disease: a continuum with visual involvements
title Alzheimer’s disease: a continuum with visual involvements
spellingShingle Alzheimer’s disease: a continuum with visual involvements
Elvira Hurtado, Lorena
616.894-053.9
617.735-07
Alzheimer’s disease, mild cognitive impairment, family history, visual function, visual acuity, contrast sensitivity, PDT
Neurociencias (Medicina)
Oftalmología
2490 Neurociencias
3201.09 Oftalmología
title_short Alzheimer’s disease: a continuum with visual involvements
title_full Alzheimer’s disease: a continuum with visual involvements
title_fullStr Alzheimer’s disease: a continuum with visual involvements
title_full_unstemmed Alzheimer’s disease: a continuum with visual involvements
title_sort Alzheimer’s disease: a continuum with visual involvements
dc.creator.none.fl_str_mv Elvira Hurtado, Lorena
López Cuenca, Inés
Hoz Montañana, María Rosa De
Salas, Mario
Sánchez-Puebla Fernández, Lidia
Ramírez Toraño, Federico
Matamoros, José Antonio
Fernández Albarral, José
Rojas Lozano, María Del Pilar
Alfonsín, Soraya
Delgado Losada, María Luisa
Ramírez, Ana I.
Salazar Corral, Juan José
Maestu Unturbe, Fernando
Gil Gregorio, Pedro
Ramírez Sebastián, José Manuel
García Martín, Elena Salobrar
author Elvira Hurtado, Lorena
author_facet Elvira Hurtado, Lorena
López Cuenca, Inés
Hoz Montañana, María Rosa De
Salas, Mario
Sánchez-Puebla Fernández, Lidia
Ramírez Toraño, Federico
Matamoros, José Antonio
Fernández Albarral, José
Rojas Lozano, María Del Pilar
Alfonsín, Soraya
Delgado Losada, María Luisa
Ramírez, Ana I.
Salazar Corral, Juan José
Maestu Unturbe, Fernando
Gil Gregorio, Pedro
Ramírez Sebastián, José Manuel
García Martín, Elena Salobrar
author_role author
author2 López Cuenca, Inés
Hoz Montañana, María Rosa De
Salas, Mario
Sánchez-Puebla Fernández, Lidia
Ramírez Toraño, Federico
Matamoros, José Antonio
Fernández Albarral, José
Rojas Lozano, María Del Pilar
Alfonsín, Soraya
Delgado Losada, María Luisa
Ramírez, Ana I.
Salazar Corral, Juan José
Maestu Unturbe, Fernando
Gil Gregorio, Pedro
Ramírez Sebastián, José Manuel
García Martín, Elena Salobrar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.894-053.9
617.735-07
Alzheimer’s disease, mild cognitive impairment, family history, visual function, visual acuity, contrast sensitivity, PDT
Neurociencias (Medicina)
Oftalmología
2490 Neurociencias
3201.09 Oftalmología
topic 616.894-053.9
617.735-07
Alzheimer’s disease, mild cognitive impairment, family history, visual function, visual acuity, contrast sensitivity, PDT
Neurociencias (Medicina)
Oftalmología
2490 Neurociencias
3201.09 Oftalmología
description Introduction: Alzheimer’s disease (AD) is the most common form of dementia affecting the central nervous system, and alteration of several visual structures has been reported. Structural retinal changes are usually accompanied by changes in visual function in this disease. The aim of this study was to analyse the differences in visual function at different stages of the pathology (family history group (FH+), mild cognitive impairment (MCI), mild AD and moderate AD) in comparison with a control group of subjects with no cognitive decline and no family history of AD. Methods: We included 53 controls, 13 subjects with FH+, 23 patients with MCI, 25 patients with mild AD and, 21 patients with moderate AD. All were ophthalmologically healthy. Visual acuity (VA), contrast sensitivity (CS), colour perception, visual integration, and fundus examination were performed. Results: The analysis showed a statistically significant decrease in VA, CS and visual integration score between the MCI, mild AD and moderate AD groups compared to the control group. In the CS higher frequencies and in the colour perception test (total errors number), statistically significant differences were also observed in the MCI, mild AD and moderate AD groups with respect to the FH+ group and also between the control and AD groups. The FH+ group showed no statistically significant difference in visual functions compared to the control group. All the test correlated with the Mini Mental State Examination score and showed good predictive value when memory decline was present, with better values when AD was at a more advanced stage. Conclusion: Alterations in visual function appear in subjects with MCI and evolve when AD is established, being stable in the initial stages of the disease (mild AD and moderate AD). Therefore, visual psychophysical tests are a useful, simple and complementary tool to neuropsychological tests to facilitate diagnosis in the preclinical and early stages of AD.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-07-06
2023
2023-07-06
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/87405
url https://hdl.handle.net/20.500.14352/87405
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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