The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment

Introduction: Memory alterations are common in Parkinson's disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients. Methods: We obtained neurological, cognit...

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Detalles Bibliográficos
Autores: Horta-Barba, Andrea|||0000-0003-0050-5466, Pagonabarraga Mora, Javier|||0000-0002-3248-704X, Martínez-Horta, Saul|||0000-0003-0125-7249, Marín-Lahoz, Juan|||0000-0003-0008-2360, Sampedro, Frederic|||0000-0002-3933-1355, Fernandez-Bobadilla, Ramon|||0000-0002-5045-732X, Botí, M.|||0000-0003-2963-6929, Bejr-kasem, Helena|||0000-0001-8828-5976, Aracil-Bolaños, Ignacio|||0000-0002-8246-5025, Pérez-Pérez, Jesús|||0000-0002-9835-0484, Pascual Sedano, Berta María|||0000-0002-9298-8241, Campolongo, Antonia|||0000-0002-7962-3264, Izquierdo, Cristina, Gómez Ansón, Beatriz|||0000-0001-7900-938X, Kulisevsky, Jaime|||0000-0003-4870-1431
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:227752
Acceso en línea:https://ddd.uab.cat/record/227752
https://dx.doi.org/urn:doi:10.3389/fneur.2020.00240
Access Level:acceso abierto
Palabra clave:PD-MCI
Free and Cued Selective Reminding Rest
Parkinson's disease
Memory
Episodic memory
Descripción
Sumario:Introduction: Memory alterations are common in Parkinson's disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients. Methods: We obtained neurological, cognitive and behavioral data from 114 PD patients and 41 healthy controls (HC). PD participants were grouped as normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) according to the Level II criteria of the Movement Disorders Society Task Force (MDS-TF). We evaluate the performance amongst groups on an episodic memory task using the Free and Cued Selective Reminding Test (FCSRT). Additionally, gray matter volume (GMV) voxel based morphometry, and mean diffusivity (MD) analyses were conducted in a subset of patients to explore the structural brain correlates of FCSRT performance. Results: Performance on all subscores of the FCSRT was significantly worse in PD-MCI than in PD-NC and HC. Delayed total recall (DTR) subscore was the best at differentiating PD-NC from PD-MCI. Using crosstabulation, DTR allowed identification of PD-MCI patients with an accuracy of 80%. Delayed free and cued recall was associated with decreased GMV and increased MD in multiple fronto-temporal and parietal areas. Conclusion: Encoding and retrieval deficits are a main characteristic of PD-MCI and are associated with structural damage in temporal, parietal and prefrontal areas.

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