Quantifying memory deficits in amnestic mild cognitive impairment.

Introduction: In the present study, we use the item-specific deficit approach (ISDA), a method for characterizing memory deficits in list-learning, to portray the memory deficits in amnestic mild cognitive impairment (aMCI).Methods: We applied the ISDA to compare memory performance of patients with...

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Bibliographic Details
Authors: Andrés, Pilar, Vico, Helena, Yáñez, Aina Maria, Siquier, Antònia, Amer Ferrer, Guillermo
Format: article
Publication Date:2019
Country:España
Institution:Conselleria de Salut i Consum del Govern de les Illes Balears
Repository:Docusalut
Language:English
OAI Identifier:oai:docusalut.com:20.500.13003/17420
Online Access:https://hdl.handle.net/20.500.13003/17420
Access Level:Open access
Keyword:Encoding deficit
Episodic memory
ISDA method
Neuropsychology
aMCI
Description
Summary:Introduction: In the present study, we use the item-specific deficit approach (ISDA), a method for characterizing memory deficits in list-learning, to portray the memory deficits in amnestic mild cognitive impairment (aMCI).Methods: We applied the ISDA to compare memory performance of patients with aMCI and healthy controls in encoding, consolidation, and retrieval using the Free and Cued Selective Reminding Test.Results: The results revealed clear differences in recall performance between patients with aMCI and controls. When analyzing the ISDA deficit indices, the results revealed a prominent encoding deficit, followed by a consolidating deficit. A greater sensitivity for the encoding index confirmed that a difficulty with encoding information plays a major role in explaining the episodic memory deficits experienced by patients with aMCI.Discussion: The present study applying the ISDA reveals great sensitivity and specificity of the encoding deficit index when identifying aMCI. As aMCI constitutes a risk factor to develop Alzheimer's disease, the current findings also confirm the need to concentrate on encoding deficits as an early diagnostic sign of cognitive decline.

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