DNA recognition with self-assembled peptide helicates
Helicates, first described by Prof. Jean-Marie Lehn more than twenty years ago, display promising antimicrobial and antitumoral effects, but despite their compelling biological properties, the development of helicates into viable chemotherapeutic agents has been hampered by the lack of versatile and...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/23305 |
| Acceso en línea: | http://hdl.handle.net/10347/23305 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias::Investigación::23 Química::2302 Bioquímica::230224 Péptidos Materias::Investigación::23 Química::2302 Bioquímica::230221 Biología molecular Materias::Investigación::23 Química::2303 Química inorgánica::230307 Compuestos de coordinación |
| Sumario: | Helicates, first described by Prof. Jean-Marie Lehn more than twenty years ago, display promising antimicrobial and antitumoral effects, but despite their compelling biological properties, the development of helicates into viable chemotherapeutic agents has been hampered by the lack of versatile and efficient stereoselective synthetic methods. In this thesis we describe the application of non-natural peptides containing the 2,2´-bipyridine ligand as platforms for the programmed self-assembly of DNA-binding metallopeptide helicates. |
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