Genética molecular de los astrocitomas

Astrocytomas are the most frequent group of intracranial tumors. Among them, glioblastoma is the most aggressive one. In this review we will describe the most common genetic abnormalities found out in astrocytomas. We will refer to the epidermal growth factor receptor (EGFR), p53, p16, PTEN and DMBT...

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Detalhes bibliográficos
Autores: Muñoz, J. (J.)|||/items/88ee4dfe-68c3-45f1-a9ca-c2315b9e7ab3, Fan, X. (X.)|||/items/d7742b83-07dd-42a5-9896-3ba70a13ed03, Inda, M.M. (M.M.)|||/items/4483203e-cb57-4415-a2fb-7d3180b4b9b0, Saez-Castresana, J. (Javier)|||/items/52f31ab0-8555-470d-af21-e677a1b3eff8
Tipo de documento: artigo
Data de publicação:2000
País:España
Recursos:Universidad de Navarra
Repositório:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:espanhol
OAI Identifier:oai:dadun.unav.edu:10171/65502
Acesso em linha:https://hdl.handle.net/10171/65502
Access Level:Acceso aberto
Palavra-chave:Glioma
Astrocitoma
Glioblastoma
Genética
Progresión tumoral
Astrocytoma
Genetics
Tumor progression
Descrição
Resumo:Astrocytomas are the most frequent group of intracranial tumors. Among them, glioblastoma is the most aggressive one. In this review we will describe the most common genetic abnormalities found out in astrocytomas. We will refer to the epidermal growth factor receptor (EGFR), p53, p16, PTEN and DMBT1 genes. We will also present certain genetic aspects that influence the progression to glioblastoma.

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