Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose

Background: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and if glucose levels on admission affected this predictive ability. Methods: A multicenter retrospective cohort...

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Authors: Zekri, Khaoula, Zamorano León, José Javier, Segura Fragoso, Antonio, Alcaide, José R., Reche, Carmen, Andrés Castillo, Alcira, Martínez Martínez, Carlos Hugo, Giner, Manel, Jiménez García, Rodrigo, López De Andrés, Ana Isabel, Navarro Cuéllar, Carlos, García Fernández, Miguel A., López Farre, Antonio José
Format: article
Publication Date:2022
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/71631
Online Access:https://hdl.handle.net/20.500.14352/71631
Access Level:Open access
Keyword:Albumin
COVID-19
Glucose
Glycated albumin
In-hospital mortality
Spike protein S1 subunit
Endocrinología
Inmunología
3205.02 Endocrinología
2412 Inmunología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/71631
network_acronym_str ES
network_name_str España
repository_id_str
spelling Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by GlucoseZekri, KhaoulaZamorano León, José JavierSegura Fragoso, AntonioAlcaide, José R.Reche, CarmenAndrés Castillo, AlciraMartínez Martínez, Carlos HugoGiner, ManelJiménez García, RodrigoLópez De Andrés, Ana IsabelNavarro Cuéllar, CarlosGarcía Fernández, Miguel A.López Farre, Antonio JoséAlbuminCOVID-19GlucoseGlycated albuminIn-hospital mortalitySpike protein S1 subunitEndocrinologíaInmunología3205.02 Endocrinología2412 InmunologíaBackground: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and if glucose levels on admission affected this predictive ability. Methods: A multicenter retrospective cohort of 1555 COVID-19-infected adult patients from public hospitals of the Madrid community were analyzed. Results: Logistic regression analysis showed increased mortality for ages higher than 49 y. After adjusting for age, comorbidities and on-admission glucose levels, it was found that on-admission serum albumin ≥3.5 g/dL was significantly associated with reduced mortality (OR 0.48; 95%CI:0.36–0.62). There was an inverse concentration-dependent association between on-admission albumin levels and <30 days in-hospital all-cause mortality. However, when on-admission glucose levels were above 125 mg/dL, higher levels of serum albumin were needed to reach an association with survival. In vitro experiments showed that the spike protein S1 subunit of SARS-CoV-2 binds to native albumin. The binding ability of native albumin to the spike protein S1 subunit was decreased in the presence of an increasing concentration of glycated albumin. Conclusions: On-admission serum albumin levels were inversely associated with <30 days in-hospital all-cause mortality. Native albumin binds the spike protein S1 subunit, suggesting that native albumin may act as a scavenger of the SARS-CoV-2 virus.MPDIUniversidad Complutense de Madrid20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/71631reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/716312026-06-02T12:44:21Z
dc.title.none.fl_str_mv Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
title Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
spellingShingle Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
Zekri, Khaoula
Albumin
COVID-19
Glucose
Glycated albumin
In-hospital mortality
Spike protein S1 subunit
Endocrinología
Inmunología
3205.02 Endocrinología
2412 Inmunología
title_short Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
title_full Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
title_fullStr Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
title_full_unstemmed Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
title_sort Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
dc.creator.none.fl_str_mv Zekri, Khaoula
Zamorano León, José Javier
Segura Fragoso, Antonio
Alcaide, José R.
Reche, Carmen
Andrés Castillo, Alcira
Martínez Martínez, Carlos Hugo
Giner, Manel
Jiménez García, Rodrigo
López De Andrés, Ana Isabel
Navarro Cuéllar, Carlos
García Fernández, Miguel A.
López Farre, Antonio José
author Zekri, Khaoula
author_facet Zekri, Khaoula
Zamorano León, José Javier
Segura Fragoso, Antonio
Alcaide, José R.
Reche, Carmen
Andrés Castillo, Alcira
Martínez Martínez, Carlos Hugo
Giner, Manel
Jiménez García, Rodrigo
López De Andrés, Ana Isabel
Navarro Cuéllar, Carlos
García Fernández, Miguel A.
López Farre, Antonio José
author_role author
author2 Zamorano León, José Javier
Segura Fragoso, Antonio
Alcaide, José R.
Reche, Carmen
Andrés Castillo, Alcira
Martínez Martínez, Carlos Hugo
Giner, Manel
Jiménez García, Rodrigo
López De Andrés, Ana Isabel
Navarro Cuéllar, Carlos
García Fernández, Miguel A.
López Farre, Antonio José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Albumin
COVID-19
Glucose
Glycated albumin
In-hospital mortality
Spike protein S1 subunit
Endocrinología
Inmunología
3205.02 Endocrinología
2412 Inmunología
topic Albumin
COVID-19
Glucose
Glycated albumin
In-hospital mortality
Spike protein S1 subunit
Endocrinología
Inmunología
3205.02 Endocrinología
2412 Inmunología
description Background: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and if glucose levels on admission affected this predictive ability. Methods: A multicenter retrospective cohort of 1555 COVID-19-infected adult patients from public hospitals of the Madrid community were analyzed. Results: Logistic regression analysis showed increased mortality for ages higher than 49 y. After adjusting for age, comorbidities and on-admission glucose levels, it was found that on-admission serum albumin ≥3.5 g/dL was significantly associated with reduced mortality (OR 0.48; 95%CI:0.36–0.62). There was an inverse concentration-dependent association between on-admission albumin levels and <30 days in-hospital all-cause mortality. However, when on-admission glucose levels were above 125 mg/dL, higher levels of serum albumin were needed to reach an association with survival. In vitro experiments showed that the spike protein S1 subunit of SARS-CoV-2 binds to native albumin. The binding ability of native albumin to the spike protein S1 subunit was decreased in the presence of an increasing concentration of glycated albumin. Conclusions: On-admission serum albumin levels were inversely associated with <30 days in-hospital all-cause mortality. Native albumin binds the spike protein S1 subunit, suggesting that native albumin may act as a scavenger of the SARS-CoV-2 virus.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/71631
url https://hdl.handle.net/20.500.14352/71631
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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