Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose

Background: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and if glucose levels on admission affected this predictive ability. Methods: A multicenter retrospective cohort...

Descripción completa

Detalles Bibliográficos
Autores: Zekri, Khaoula, Zamorano León, José Javier, Segura Fragoso, Antonio, Alcaide, José R., Reche, Carmen, Andrés Castillo, Alcira, Martínez Martínez, Carlos Hugo, Giner, Manel, Jiménez García, Rodrigo, López De Andrés, Ana Isabel, Navarro Cuéllar, Carlos, García Fernández, Miguel A., López Farre, Antonio José
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/71631
Acceso en línea:https://hdl.handle.net/20.500.14352/71631
Access Level:acceso abierto
Palabra clave:Albumin
COVID-19
Glucose
Glycated albumin
In-hospital mortality
Spike protein S1 subunit
Endocrinología
Inmunología
3205.02 Endocrinología
2412 Inmunología
Descripción
Sumario:Background: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and if glucose levels on admission affected this predictive ability. Methods: A multicenter retrospective cohort of 1555 COVID-19-infected adult patients from public hospitals of the Madrid community were analyzed. Results: Logistic regression analysis showed increased mortality for ages higher than 49 y. After adjusting for age, comorbidities and on-admission glucose levels, it was found that on-admission serum albumin ≥3.5 g/dL was significantly associated with reduced mortality (OR 0.48; 95%CI:0.36–0.62). There was an inverse concentration-dependent association between on-admission albumin levels and <30 days in-hospital all-cause mortality. However, when on-admission glucose levels were above 125 mg/dL, higher levels of serum albumin were needed to reach an association with survival. In vitro experiments showed that the spike protein S1 subunit of SARS-CoV-2 binds to native albumin. The binding ability of native albumin to the spike protein S1 subunit was decreased in the presence of an increasing concentration of glycated albumin. Conclusions: On-admission serum albumin levels were inversely associated with <30 days in-hospital all-cause mortality. Native albumin binds the spike protein S1 subunit, suggesting that native albumin may act as a scavenger of the SARS-CoV-2 virus.

Similares en LA Referencia