Tyrosinase inactivation in its action on dopa
Under aerobic or anaerobic conditions, tyrosinase undergoes a process of irreversible inactivation induced by its physiological substrate L-dopa. Under aerobic conditions, this inactivation occurs through a process of suicide inactivation involving the form oxy-tyrosinase. Under anaerobic conditions...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Universidad Católica San Antonio de Murcia (UCAM) |
| Repositorio: | RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia |
| OAI Identifier: | oai:repositorio.ucam.edu:10952/7323 |
| Acceso en línea: | http://hdl.handle.net/10952/7323 https://doi.org/10.1016/j.bbapap.2010.02.015 |
| Access Level: | acceso abierto |
| Palabra clave: | o-Diphenol Stereospecificity Inactivation Suicide Tyrosinase |
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Tyrosinase inactivation in its action on dopaMuñoz Muñoz, Jose LuisAcosta Motos, José RamónGarcía Molina, FranciscoVaron, RamonGarcía Ruíz, Pedro AntonioTudela, JoseGarcía Cánovas, FranciscoRodríguez López, José Neptunoo-DiphenolStereospecificityInactivationSuicideTyrosinaseUnder aerobic or anaerobic conditions, tyrosinase undergoes a process of irreversible inactivation induced by its physiological substrate L-dopa. Under aerobic conditions, this inactivation occurs through a process of suicide inactivation involving the form oxy-tyrosinase. Under anaerobic conditions, both the met- and deoxytyrosinase forms undergo irreversible inactivation. Suicide inactivation in aerobic conditions is slower than the irreversible inactivation under anaerobic conditions. The enzyme has less affinity for the isomer D-dopa than for L-dopa but the velocity of inactivation is the same. We propose mechanisms to explain these processes.En condiciones aeróbicas o anaeróbicas, la tirosinasa experimenta un proceso de inactivación irreversible inducido por su sustrato fisiológico L-dopa. Bajo condiciones aeróbicas, esta inactivación ocurre a través de un proceso de inactivación suicida que implica la forma oxy-tirosinasa. Bajo condiciones anaeróbicas, tanto las formas met- como deoxytirosinasa experimentan una inactivación irreversible. La inactivación suicida en condiciones aeróbicas es más lenta que la inactivación irreversible bajo condiciones anaeróbicas. La enzima tiene menos afinidad por el isómero D-dopa que por L-dopa, pero la velocidad de inactivación es la misma. Proponemos mecanismos para explicar estos procesos.Agricultura y VeterinariaCiencias AmbientalesMuñoz Muñoz, Jose Luis2010info:eu-repo/semantics/articlehttp://hdl.handle.net/10952/7323https://doi.org/10.1016/j.bbapap.2010.02.015reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murciainstname:Universidad Católica San Antonio de Murcia (UCAM)Inglésinfo:eu-repo/semantics/openAccessoai:repositorio.ucam.edu:10952/73232026-06-07T18:35:21Z |
| dc.title.none.fl_str_mv |
Tyrosinase inactivation in its action on dopa |
| title |
Tyrosinase inactivation in its action on dopa |
| spellingShingle |
Tyrosinase inactivation in its action on dopa Muñoz Muñoz, Jose Luis o-Diphenol Stereospecificity Inactivation Suicide Tyrosinase |
| title_short |
Tyrosinase inactivation in its action on dopa |
| title_full |
Tyrosinase inactivation in its action on dopa |
| title_fullStr |
Tyrosinase inactivation in its action on dopa |
| title_full_unstemmed |
Tyrosinase inactivation in its action on dopa |
| title_sort |
Tyrosinase inactivation in its action on dopa |
| dc.creator.none.fl_str_mv |
Muñoz Muñoz, Jose Luis Acosta Motos, José Ramón García Molina, Francisco Varon, Ramon García Ruíz, Pedro Antonio Tudela, Jose García Cánovas, Francisco Rodríguez López, José Neptuno |
| author |
Muñoz Muñoz, Jose Luis |
| author_facet |
Muñoz Muñoz, Jose Luis Acosta Motos, José Ramón García Molina, Francisco Varon, Ramon García Ruíz, Pedro Antonio Tudela, Jose García Cánovas, Francisco Rodríguez López, José Neptuno |
| author_role |
author |
| author2 |
Acosta Motos, José Ramón García Molina, Francisco Varon, Ramon García Ruíz, Pedro Antonio Tudela, Jose García Cánovas, Francisco Rodríguez López, José Neptuno |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Muñoz Muñoz, Jose Luis |
| dc.subject.none.fl_str_mv |
o-Diphenol Stereospecificity Inactivation Suicide Tyrosinase |
| topic |
o-Diphenol Stereospecificity Inactivation Suicide Tyrosinase |
| description |
Under aerobic or anaerobic conditions, tyrosinase undergoes a process of irreversible inactivation induced by its physiological substrate L-dopa. Under aerobic conditions, this inactivation occurs through a process of suicide inactivation involving the form oxy-tyrosinase. Under anaerobic conditions, both the met- and deoxytyrosinase forms undergo irreversible inactivation. Suicide inactivation in aerobic conditions is slower than the irreversible inactivation under anaerobic conditions. The enzyme has less affinity for the isomer D-dopa than for L-dopa but the velocity of inactivation is the same. We propose mechanisms to explain these processes. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10952/7323 https://doi.org/10.1016/j.bbapap.2010.02.015 |
| url |
http://hdl.handle.net/10952/7323 https://doi.org/10.1016/j.bbapap.2010.02.015 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia instname:Universidad Católica San Antonio de Murcia (UCAM) |
| instname_str |
Universidad Católica San Antonio de Murcia (UCAM) |
| reponame_str |
RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia |
| collection |
RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia |
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1869403810272641024 |
| score |
15,300719 |