Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H insertion. Synthesis of Benzofused Six-Membered Azaheterocycles
Cp*RuCl-based catalyst enables the expedient access to a variety of benzofused six- membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild rea...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/23357 |
| Acceso en línea: | http://hdl.handle.net/10347/23357 |
| Access Level: | acceso abierto |
| Sumario: | Cp*RuCl-based catalyst enables the expedient access to a variety of benzofused six- membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild reaction conditions (room temperature, < 15 min) and with excellent functional group tolerance. The synthetic utility of the final products and a mechanistic rationale are also discussed. |
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