New Catalytic Routes to Benzofused Seven-Membered Azaheterocycles

Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues. The design of new catalytic sustainable routes to these nuclei still remains as a main...

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Detalhes bibliográficos
Autor: Velasco Rubio, Álvaro
Formato: tesis doctoral
Fecha de publicación:2021
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/27488
Acesso em linha:http://hdl.handle.net/10347/27488
Access Level:acceso abierto
Palavra-chave:Materias::Investigación::23 Química::2306 Química orgánica::230611 Compuestos organometálicos
Descrição
Resumo:Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues. The design of new catalytic sustainable routes to these nuclei still remains as a main challenge to the organic chemistry. In this thesis the synthesis of these three nuclei upon generation of a key metalp- allyl intermediate through Csp2-H activation, allylic C-H activation, and Rh-hydride catalysis have been successfully accomplished.