Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies

Organophosphate flame retardants (OPFRs) have increasingly replaced polybrominated diphenyl ethers (PBDEs) in various consumer products and raw materials, due to regulatory restrictions on PBDEs. However, concerns about the toxicity and environmental persistence of OPFRs are growing. This review sum...

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Detalles Bibliográficos
Autores: Pyambri, Maryam, Jaumot, Joaquim, Bedia, Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/388923
Acceso en línea:http://hdl.handle.net/10261/388923
https://api.elsevier.com/content/abstract/scopus_id/105003696343
Access Level:acceso abierto
Palabra clave:Toxicity
New Approach Methodologies
Cell cultures
In vitro methods
Omics
Organophosphate flame retardants
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/9
Ensure healthy lives and promote well-being for all at all ages
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
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spelling Toxicity Assessment of Organophosphate Flame Retardants Using New Approach MethodologiesPyambri, MaryamJaumot, JoaquimBedia, CarmenToxicityNew Approach MethodologiesCell culturesIn vitro methodsOmicsOrganophosphate flame retardantshttp://metadata.un.org/sdg/3http://metadata.un.org/sdg/9Ensure healthy lives and promote well-being for all at all agesBuild resilient infrastructure, promote inclusive and sustainable industrialization and foster innovationOrganophosphate flame retardants (OPFRs) have increasingly replaced polybrominated diphenyl ethers (PBDEs) in various consumer products and raw materials, due to regulatory restrictions on PBDEs. However, concerns about the toxicity and environmental persistence of OPFRs are growing. This review summarizes current research on the toxicity of OPFRs, with a focus on New Approach Methodologies (NAMs) that aim to eliminate the need for animal testing. NAMs, including in vitro models, omics technologies, and computational methods, provide valuable insights into the cellular and molecular effects of OPFR exposure. Evidence suggests that OPFRs may disrupt multiple organ systems, including the nervous, hepatic, pulmonary, reproductive, and endocrine systems. Additionally, the metabolic transformation of OPFRs can increase their toxicity, raising concerns about long-term exposure risks. While NAM studies provide valuable insights, further research is needed to refine risk-assessment frameworks and improve our understanding of the long-term effects of OPFR exposure, particularly at concentrations found in the environment. This new knowledge will help develop more accurate regulatory guidelines and ensure the better protection of public and environmental health.This work was funded by MCIN/AEI/10.13039/501100011033 and ERDF/EU, grant number PID2022-140392OB-I00.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia e Innovación (España)0000-0002-5836-66170000-0003-1461-32730000-0003-4584-5843Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/388923https://api.elsevier.com/content/abstract/scopus_id/105003696343reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MCIN/AEI/10.13039Toxicshttps://doi.org/10.3390/toxics13040297Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3889232026-05-22T06:33:51Z
dc.title.none.fl_str_mv Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
title Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
spellingShingle Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
Pyambri, Maryam
Toxicity
New Approach Methodologies
Cell cultures
In vitro methods
Omics
Organophosphate flame retardants
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/9
Ensure healthy lives and promote well-being for all at all ages
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
title_short Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
title_full Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
title_fullStr Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
title_full_unstemmed Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
title_sort Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
dc.creator.none.fl_str_mv Pyambri, Maryam
Jaumot, Joaquim
Bedia, Carmen
author Pyambri, Maryam
author_facet Pyambri, Maryam
Jaumot, Joaquim
Bedia, Carmen
author_role author
author2 Jaumot, Joaquim
Bedia, Carmen
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
0000-0002-5836-6617
0000-0003-1461-3273
0000-0003-4584-5843
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Toxicity
New Approach Methodologies
Cell cultures
In vitro methods
Omics
Organophosphate flame retardants
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/9
Ensure healthy lives and promote well-being for all at all ages
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
topic Toxicity
New Approach Methodologies
Cell cultures
In vitro methods
Omics
Organophosphate flame retardants
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/9
Ensure healthy lives and promote well-being for all at all ages
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
description Organophosphate flame retardants (OPFRs) have increasingly replaced polybrominated diphenyl ethers (PBDEs) in various consumer products and raw materials, due to regulatory restrictions on PBDEs. However, concerns about the toxicity and environmental persistence of OPFRs are growing. This review summarizes current research on the toxicity of OPFRs, with a focus on New Approach Methodologies (NAMs) that aim to eliminate the need for animal testing. NAMs, including in vitro models, omics technologies, and computational methods, provide valuable insights into the cellular and molecular effects of OPFR exposure. Evidence suggests that OPFRs may disrupt multiple organ systems, including the nervous, hepatic, pulmonary, reproductive, and endocrine systems. Additionally, the metabolic transformation of OPFRs can increase their toxicity, raising concerns about long-term exposure risks. While NAM studies provide valuable insights, further research is needed to refine risk-assessment frameworks and improve our understanding of the long-term effects of OPFR exposure, particularly at concentrations found in the environment. This new knowledge will help develop more accurate regulatory guidelines and ensure the better protection of public and environmental health.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/388923
https://api.elsevier.com/content/abstract/scopus_id/105003696343
url http://hdl.handle.net/10261/388923
https://api.elsevier.com/content/abstract/scopus_id/105003696343
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MCIN/AEI/10.13039
Toxics
https://doi.org/10.3390/toxics13040297
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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