Interaction between acetylsalicylic acid and a cationic amphiphile model: an experimental approach using surface techniques
Mechanical and morphological effects of monolayers of octadecylamine upon aspirin adsorption are monitored by Langmuir isotherms measurements and Brewster angle microscopy. Aspirin induced a notable expansion of the corresponding isotherms and a concentration-dependence of the mechanical stability o...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/108013 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/108013 |
| Access Level: | acceso abierto |
| Palabra clave: | 544 Drug–lipid interaction Langmuir monolayer Brewster angle microscopy Reflection spectroscopy Química física (Química) 2307 Química Física |
| Sumario: | Mechanical and morphological effects of monolayers of octadecylamine upon aspirin adsorption are monitored by Langmuir isotherms measurements and Brewster angle microscopy. Aspirin induced a notable expansion of the corresponding isotherms and a concentration-dependence of the mechanical stability of the films as a consequence of the subtle balance between the solubility of the amine and the monolayer stabilization induced by the ion-pairs, as corroborated by Brewster Angle Microscopy images. The incorporation of the aspirin into the interface was confirmed by UV–vis reflection spectroscopy. Some comments on the feasibility of using aliphatic amines for drug delivery of anionic species are presented. |
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