Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk

Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperurice...

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Authors: Rubín-García, María, Vitelli-Storelli, Facundo, Álvarez-Álvarez, Laura, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Hernáez, Álvaro, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Serra-Majem, Luís I, Cano-Ibañez, Naomi, Tur, Josep A, Marcos-Delgado, Alba, Tresserra-Rimbau, Anna, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Vázquez-Ruiz, Zenaida, Babio, Nancy, Barragán, Rocío, Castañer-Niño, Olga, Razquin, Cristina, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, González-Palacios, Sandra, Morey, Marga, García-Rios, Antonio, Castro-Barquero, Sara, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Ruiz-Canela, Miguel, Castro-Salomó, Antoni, Pascual-Castelló, Eva Cristina, Moldon, Verónica, Bullón-Vela, Vanessa, Sorto-Sanchez, Carolina, Cenoz-Osinaga, Juan Carlos, Gutiérrez, Liliana, Mengual, Maira, Lamuela-Raventós, Rosa María, Martín-Sánchez, Vicente, PREDIMED‐Plus Trial Investigators
Format: article
Publication Date:2022
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18836
Online Access:http://hdl.handle.net/20.500.12105/18836
Access Level:Open access
Keyword:Hyperuricemia
Polyphenols
Uric acid
Hidroxibenzoatos
Estudios Transversales
Factores de Riesgo
Polifenoles
Humanos
Factores de Riesgo de Enfermedad Cardiaca
Femenino
Enfermedades Cardiovasculares
Ácido úrico
Ácidos Cuméricos
Hiperuricemia
Masculino
Male
Female
Humans
Uric Acid
Cross-Sectional Studies
Coumaric Acids
Cardiovascular Diseases
Risk Factors
Heart Disease Risk Factors
Hydroxybenzoates
Description
Summary:Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.

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