Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation

El copyright pertenece a The American Society for Cell Biology. The final versión of the paper is available at http://www.pubmedcentral.nih.gov

Detalhes bibliográficos
Autores: Cerezo, Ana, Martínez-Alonso, Carlos, Lanzarot, Diego, Fischer, Siegmund, Franke, Thomas F., Rebollo, Angelita
Formato: artículo
Fecha de publicación:1998
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::6266176e6d1303e6c05a5624736e0352
Acesso em linha:http://hdl.handle.net/10261/3467
Access Level:acceso abierto
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spelling Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 DeprivationCerezo, AnaMartínez-Alonso, CarlosLanzarot, DiegoFischer, SiegmundFranke, Thomas F.Rebollo, AngelitaEl copyright pertenece a The American Society for Cell Biology. The final versión of the paper is available at http://www.pubmedcentral.nih.govWe have shown previously that interleukin-4 (IL-4) protects TS1ab cells from apoptosis, but very little is known about the mechanism by which IL-4 exerts this effect. We found that Akt activity, which is dependent on phosphatidylinositol 3 kinase, is reduced in IL-4-deprived TS1ab cells. Overexpression of wild-type Akt or a constitutively active Akt mutant protects cells from IL-4 deprivation-induced apoptosis. Readdition of IL-4 before the commitment point is able to restore Akt activity. We also show expression and c-Jun N-terminal kinase 2 activation after IL-4 deprivation. Overexpression of the constitutively activated Akt mutant in IL-4-deprived cells correlates with inhibition of c-Jun N-terminal kinase 2 activity. Finally, TS1ab survival is independent of Bcl-2, Bcl-x, or Bax.Peer reviewedAmerican Society for Cell Biology200820081998info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501360048 bytesapplication/pdfhttp://hdl.handle.net/10261/3467reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::6266176e6d1303e6c05a5624736e03522026-05-22T06:33:51Z
dc.title.none.fl_str_mv Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
title Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
spellingShingle Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
Cerezo, Ana
title_short Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
title_full Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
title_fullStr Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
title_full_unstemmed Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
title_sort Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation
dc.creator.none.fl_str_mv Cerezo, Ana
Martínez-Alonso, Carlos
Lanzarot, Diego
Fischer, Siegmund
Franke, Thomas F.
Rebollo, Angelita
author Cerezo, Ana
author_facet Cerezo, Ana
Martínez-Alonso, Carlos
Lanzarot, Diego
Fischer, Siegmund
Franke, Thomas F.
Rebollo, Angelita
author_role author
author2 Martínez-Alonso, Carlos
Lanzarot, Diego
Fischer, Siegmund
Franke, Thomas F.
Rebollo, Angelita
author2_role author
author
author
author
author
description El copyright pertenece a The American Society for Cell Biology. The final versión of the paper is available at http://www.pubmedcentral.nih.gov
publishDate 1998
dc.date.none.fl_str_mv 1998
2008
2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/3467
url http://hdl.handle.net/10261/3467
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 360048 bytes
application/pdf
dc.publisher.none.fl_str_mv American Society for Cell Biology
publisher.none.fl_str_mv American Society for Cell Biology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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