Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment

Previous studies have reported that the regulatory function of the different c-Jun N-terminal kinases isoforms (JNK1, JNK2, and JNK3) play an essential role in neurological disorders, such as epilepsy and metabolic-cognitive alterations. Accordingly, JNKs have emerged as suitable therapeutic strateg...

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Detalles Bibliográficos
Autores: Busquets Figueras, Oriol, Ettcheto Arriola, Miren, Cano Fernández, Amanda, Manzine, Patricia, Sánchez-López, E. (Elena), Espinosa-Jiménez, Triana, Verdaguer Cardona, Ester, Castro-Torres, Rubén Darío, Beas Zárate, Carlos, Sureda, Francesc X., Olloquequi, Jordi, Auladell i Costa, M. Carme, Folch, Jaume, Camins Espuny, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/151078
Acceso en línea:https://hdl.handle.net/2445/151078
Access Level:acceso abierto
Palabra clave:Cervell
Diabetis no-insulinodependent
Epilèpsia
Brain
Non-insulin-dependent diabetes
Epilepsy
Descripción
Sumario:Previous studies have reported that the regulatory function of the different c-Jun N-terminal kinases isoforms (JNK1, JNK2, and JNK3) play an essential role in neurological disorders, such as epilepsy and metabolic-cognitive alterations. Accordingly, JNKs have emerged as suitable therapeutic strategies. In fact, it has been demonstrated that some unspecific JNK inhibitors exert antidiabetic and neuroprotective effects, albeit they usually show high toxicity or lack therapeutic value. In this sense, natural specific JNK inhibitors, such as Licochalcone A, are promising candidates. Nonetheless, research on the understanding of the role of each of the JNKs remains mandatory in order to progress on the identification of new selective JNK isoform inhibitors. In the present review, a summary on the current gathered data on the role of JNKs in pathology is presented, as well as a discussion on their potential role in pathologies like epilepsy and metabolic-cognitive injury. Moreover, data on the effects of synthetic small molecule inhibitors that modulate JNK-dependent pathways in the brain and peripheral tissues is reviewed.

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