Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review

Gastrointestinal (GI) environment is influenced by several factors (gender, genetics, sex, disease state, food) leading to oral drug absorption variability or to low bioavailability. In this scenario, gastroretentive drug delivery systems (GRDDS) have been developed in order to solve absorption prob...

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Detalles Bibliográficos
Autores: Mora Castaño, Gloria, Domínguez Robles, Juan, Himawan, Achmad, Millán Jiménez, Mónica, Caraballo Rodríguez, Isidoro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/165393
Acceso en línea:https://hdl.handle.net/11441/165393
https://doi.org/10.1016/j.ijpharm.2024.124543
Access Level:acceso abierto
Palabra clave:3D printing
Drug delivery system
Gastroretentive floating system
Personalized medicine
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spelling Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive ReviewMora Castaño, GloriaDomínguez Robles, JuanHimawan, AchmadMillán Jiménez, MónicaCaraballo Rodríguez, Isidoro3D printingDrug delivery systemGastroretentive floating systemPersonalized medicineGastrointestinal (GI) environment is influenced by several factors (gender, genetics, sex, disease state, food) leading to oral drug absorption variability or to low bioavailability. In this scenario, gastroretentive drug delivery systems (GRDDS) have been developed in order to solve absorption problems, to lead to a more effective local therapy or to allow sustained drug release during a longer time period than the typical oral sustained release dosage forms. Among all GRDDS, floating systems seem to provide a promising and practical approach for achieving a long intra-gastric residence time and sustained release profile. In the last years, a novel technique is being used to manufacture this kind of systems: three-dimensional (3D) printing technology. This technique provides a versatile and easy process to manufacture personalized drug delivery systems. This work presents a systematic review of the main 3D printing based designs proposed up to date to manufacture floating systems. We have also summarized the most important parameters involved in buoyancy and sustained release of the systems, in order to facilitate the scale up of this technology to industrial level. Finally, a section discussing about the influence of materials in drug release, their biocompatibility and safety considerations have been included.Junta de Andalucía US-1380923Ministerio de Ciencia, Innovación y Universidades FPU18/05665Ministerio de Ciencia e Innovación RYC-2021–034357-IElsevierFarmacia y Tecnología FarmacéuticaJunta de AndalucíaMinisterio de Ciencia, Innovación y Universidades (MICINN). EspañaMinisterio de Ciencia e Innovación (MICIN). España2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/165393https://doi.org/10.1016/j.ijpharm.2024.124543reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Pharmaceutics, 663, 124543.US-1380923FPU18/05665RYC-2021–034357-Ihttps://doi.org/10.1016/j.ijpharm.2024.124543info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1653932026-06-17T12:51:07Z
dc.title.none.fl_str_mv Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review
title Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review
spellingShingle Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review
Mora Castaño, Gloria
3D printing
Drug delivery system
Gastroretentive floating system
Personalized medicine
title_short Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review
title_full Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review
title_fullStr Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review
title_full_unstemmed Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review
title_sort Current Tends in 3D Printed Gastroretentive Floating Drug Delivery Systems: A Comprehensive Review
dc.creator.none.fl_str_mv Mora Castaño, Gloria
Domínguez Robles, Juan
Himawan, Achmad
Millán Jiménez, Mónica
Caraballo Rodríguez, Isidoro
author Mora Castaño, Gloria
author_facet Mora Castaño, Gloria
Domínguez Robles, Juan
Himawan, Achmad
Millán Jiménez, Mónica
Caraballo Rodríguez, Isidoro
author_role author
author2 Domínguez Robles, Juan
Himawan, Achmad
Millán Jiménez, Mónica
Caraballo Rodríguez, Isidoro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Farmacia y Tecnología Farmacéutica
Junta de Andalucía
Ministerio de Ciencia, Innovación y Universidades (MICINN). España
Ministerio de Ciencia e Innovación (MICIN). España
dc.subject.none.fl_str_mv 3D printing
Drug delivery system
Gastroretentive floating system
Personalized medicine
topic 3D printing
Drug delivery system
Gastroretentive floating system
Personalized medicine
description Gastrointestinal (GI) environment is influenced by several factors (gender, genetics, sex, disease state, food) leading to oral drug absorption variability or to low bioavailability. In this scenario, gastroretentive drug delivery systems (GRDDS) have been developed in order to solve absorption problems, to lead to a more effective local therapy or to allow sustained drug release during a longer time period than the typical oral sustained release dosage forms. Among all GRDDS, floating systems seem to provide a promising and practical approach for achieving a long intra-gastric residence time and sustained release profile. In the last years, a novel technique is being used to manufacture this kind of systems: three-dimensional (3D) printing technology. This technique provides a versatile and easy process to manufacture personalized drug delivery systems. This work presents a systematic review of the main 3D printing based designs proposed up to date to manufacture floating systems. We have also summarized the most important parameters involved in buoyancy and sustained release of the systems, in order to facilitate the scale up of this technology to industrial level. Finally, a section discussing about the influence of materials in drug release, their biocompatibility and safety considerations have been included.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/165393
https://doi.org/10.1016/j.ijpharm.2024.124543
url https://hdl.handle.net/11441/165393
https://doi.org/10.1016/j.ijpharm.2024.124543
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Pharmaceutics, 663, 124543.
US-1380923
FPU18/05665
RYC-2021–034357-I
https://doi.org/10.1016/j.ijpharm.2024.124543
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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