On the consequences of purging and Linkage on fitness and genetic diversity

Using computer simulation we explore the consequences of linkage on the inbreeding load of an equilibrium population, and on the efficiency of purging and the loss of genetic diversity after a reduction in population size. We find that linkage tends to cause increased inbreeding load due to the buil...

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Detalhes bibliográficos
Autores: Bersabé García, Diego, Caballero, Armando, Pérez-Figueroa, Andrés, García-Dorado, Aurora
Tipo de documento: artigo
Data de publicação:2016
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/23370
Acesso em linha:https://hdl.handle.net/20.500.14352/23370
Access Level:Acceso aberto
Palavra-chave:575.17
Inbreeding load
Inbreeding
Depression
Genetic diversity
Associative
Overdominance
Genética
2409 Genética
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oai_identifier_str oai:docta.ucm.es:20.500.14352/23370
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network_name_str España
repository_id_str
spelling On the consequences of purging and Linkage on fitness and genetic diversityBersabé García, DiegoCaballero, ArmandoPérez-Figueroa, AndrésGarcía-Dorado, Aurora575.17Inbreeding loadInbreedingDepressionGenetic diversityAssociativeOverdominanceGenética2409 GenéticaUsing computer simulation we explore the consequences of linkage on the inbreeding load of an equilibrium population, and on the efficiency of purging and the loss of genetic diversity after a reduction in population size. We find that linkage tends to cause increased inbreeding load due to the build up of coupling groups of (partially) recessive deleterious alleles. It also induces associative overdominance at neutral sites but rarely causes increased neutral genetic diversity in equilibrium populations. After a reduction in population size, linkage can cause some delay both for the expression of the inbreeding load and the corresponding purging. However, reasonable predictions can be obtained for the evolution of fitness under inbreeding and purging by using empirical estimates of the inbreeding depression rate. Purging selection against homozygotes for deleterious alleles affects the population’s pedigree. Furthermore, it can slow the loss of genetic diversity compared to that expected from the variance of gametic contributions to the breeding group and even from pedigree inbreeding. Under some conditions, this can lead to a smaller loss of genetic diversity, even below that expected from population size in the absence of selection.Genetics Society of AmericaUniversidad Complutense de Madrid20162016-01-0120162016-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/23370reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/233702026-06-02T12:44:21Z
dc.title.none.fl_str_mv On the consequences of purging and Linkage on fitness and genetic diversity
title On the consequences of purging and Linkage on fitness and genetic diversity
spellingShingle On the consequences of purging and Linkage on fitness and genetic diversity
Bersabé García, Diego
575.17
Inbreeding load
Inbreeding
Depression
Genetic diversity
Associative
Overdominance
Genética
2409 Genética
title_short On the consequences of purging and Linkage on fitness and genetic diversity
title_full On the consequences of purging and Linkage on fitness and genetic diversity
title_fullStr On the consequences of purging and Linkage on fitness and genetic diversity
title_full_unstemmed On the consequences of purging and Linkage on fitness and genetic diversity
title_sort On the consequences of purging and Linkage on fitness and genetic diversity
dc.creator.none.fl_str_mv Bersabé García, Diego
Caballero, Armando
Pérez-Figueroa, Andrés
García-Dorado, Aurora
author Bersabé García, Diego
author_facet Bersabé García, Diego
Caballero, Armando
Pérez-Figueroa, Andrés
García-Dorado, Aurora
author_role author
author2 Caballero, Armando
Pérez-Figueroa, Andrés
García-Dorado, Aurora
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 575.17
Inbreeding load
Inbreeding
Depression
Genetic diversity
Associative
Overdominance
Genética
2409 Genética
topic 575.17
Inbreeding load
Inbreeding
Depression
Genetic diversity
Associative
Overdominance
Genética
2409 Genética
description Using computer simulation we explore the consequences of linkage on the inbreeding load of an equilibrium population, and on the efficiency of purging and the loss of genetic diversity after a reduction in population size. We find that linkage tends to cause increased inbreeding load due to the build up of coupling groups of (partially) recessive deleterious alleles. It also induces associative overdominance at neutral sites but rarely causes increased neutral genetic diversity in equilibrium populations. After a reduction in population size, linkage can cause some delay both for the expression of the inbreeding load and the corresponding purging. However, reasonable predictions can be obtained for the evolution of fitness under inbreeding and purging by using empirical estimates of the inbreeding depression rate. Purging selection against homozygotes for deleterious alleles affects the population’s pedigree. Furthermore, it can slow the loss of genetic diversity compared to that expected from the variance of gametic contributions to the breeding group and even from pedigree inbreeding. Under some conditions, this can lead to a smaller loss of genetic diversity, even below that expected from population size in the absence of selection.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/23370
url https://hdl.handle.net/20.500.14352/23370
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Genetics Society of America
publisher.none.fl_str_mv Genetics Society of America
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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