Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information rega...

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Detalles Bibliográficos
Autores: Escobedo-Ruíz, Araceli, Barquera, Rodrigo, González-Martín, Antonio, Argüelles-San Millán, Juan Manuel, Uribe-Duarte, María Guadalupe, Iraíz Hernández-Zaragoza, Diana, Clayton, Stephen, Arrieta-Bolaños, Esteban, Ruíz Corral, María de Jesús, Goné-Vázquez, Isis, Arellano-Prado, Francia Paulina, Martínez-Álvarez, Julio César, García-Arias, Víctor Eduardo, Rodríguez-López, Marla Estefanía, Bravo-Acevedo, Alicia, Sánchez-Fernández, María Guadalupe de Jesús, Aguilar-Campos, Jesús Abraham, Gómez-Navarro, Benjamín, Sandoval-Sandoval, Mario J., Serrano-Osuna, Ricardo, Yunis, Edmond J., Zúñiga, Joaquín, Bekker-Méndez, Carolina, Granados, Julio
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/13846
Acceso en línea:https://hdl.handle.net/20.500.14352/13846
Access Level:acceso abierto
Palabra clave:575.17(72)
HLA
Immunogenetics
Population genetics
Baja California
Admixture
Genética
2409 Genética
Descripción
Sumario:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84% by ML; 42.03% of European haplotypes) and Native American (43.72 ± 2.36% by ML; 40.24% of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98% by ML; 9.36% of African haplotypes).

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