Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib
Chronic myeloid leukemia; BCR-ABL1 transcripts; Response to imatinib
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/6532 |
| Acceso en línea: | https://hdl.handle.net/11351/6532 http://hdl.handle.net/11351/6532 |
| Access Level: | acceso abierto |
| Palabra clave: | Leucèmia mieloide crònica Imatinib Anàlisi de supervivència (Biometria) DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myelogenous, Chronic, BCR-ABL Positive CHEMICALS AND DRUGS::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Survival Analysis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mielogenosa crónica BCR-ABL positiva COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::amidas::benzamidas::mesilato de imatinib TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis de supervivencia |
| id |
ES_0f9edaaf30c0d92dcc8cf3f965cd264f |
|---|---|
| oai_identifier_str |
oai:recercat.cat:11351/6532 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with ImatinibMarcé, SilviaGarcía, OlgaEstrada, NataliaVélez, PatriciaCortes, MontseCabezón, MartaXicoy, BlancaLeucèmia mieloide crònicaImatinibAnàlisi de supervivència (Biometria)DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myelogenous, Chronic, BCR-ABL PositiveCHEMICALS AND DRUGS::Organic Chemicals::Amides::Benzamides::Imatinib MesylateHEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Survival AnalysisENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mielogenosa crónica BCR-ABL positivaCOMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::amidas::benzamidas::mesilato de imatinibTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis de supervivenciaChronic myeloid leukemia; BCR-ABL1 transcripts; Response to imatinibLeucemia mieloide crónica; Transcripciones de BCR-ABL1; Respuesta al imatinibLeucèmia mieloide crònica; Transcripcions BCR-ABL1; Resposta a imatinibThe most frequent BCR-ABL1-p210 transcripts in chronic myeloid leukemia (CML) are e14a2 and e13a2. Imatinib (IM) is the most common first-line tyrosine–kinase inhibitor (TKI) used to treat CML. Some studies suggest that BCR-ABL1 transcript types confer different responses to IM. The objective of this study was to correlate the expression of e14a2 or e13a2 to clinical characteristics, cumulative cytogenetic and molecular responses to IM, acquisition of deep molecular response (DMR) and its duration (sDMR), progression rate (CIP), overall survival (OS), and treatment-free remission (TFR) rate. We studied 202 CML patients, 76 expressing the e13a2 and 126 the e14a2, and correlated the differential transcript expression with the above-mentioned parameters. There were no differences in the cumulative incidence of cytogenetic responses nor in the acquisition of DMR and sDMR between the two groups, but the e14a2 transcript had a positive impact on molecular response during the first 6 months, whereas the e13a2 was associated with improved long-term OS. No correlation was observed between the transcript type and TFR rate.MDPI[Marcé S, Xicoy B, García O, Cabezón M, Estrada N] Myeloid Neoplasms Group, Hematology Department, ICO Badalona-Hospital Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain. [Vélez P] Hematology Department, ICO Hospitalet-Hospital Duran y Reynals, l’Hospitalet de Llobregat, Spain. [Cortés M] Hospital General de Granollers, Granollers, SpainHospital General de Granollers202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/6532http://hdl.handle.net/11351/6532Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Clinical Medicine;10(14)https://doi.org/10.3390/jcm10143146Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/65322026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib |
| title |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib |
| spellingShingle |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib Marcé, Silvia Leucèmia mieloide crònica Imatinib Anàlisi de supervivència (Biometria) DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myelogenous, Chronic, BCR-ABL Positive CHEMICALS AND DRUGS::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Survival Analysis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mielogenosa crónica BCR-ABL positiva COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::amidas::benzamidas::mesilato de imatinib TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis de supervivencia |
| title_short |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib |
| title_full |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib |
| title_fullStr |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib |
| title_full_unstemmed |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib |
| title_sort |
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib |
| dc.creator.none.fl_str_mv |
Marcé, Silvia García, Olga Estrada, Natalia Vélez, Patricia Cortes, Montse Cabezón, Marta Xicoy, Blanca |
| author |
Marcé, Silvia |
| author_facet |
Marcé, Silvia García, Olga Estrada, Natalia Vélez, Patricia Cortes, Montse Cabezón, Marta Xicoy, Blanca |
| author_role |
author |
| author2 |
García, Olga Estrada, Natalia Vélez, Patricia Cortes, Montse Cabezón, Marta Xicoy, Blanca |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
[Marcé S, Xicoy B, García O, Cabezón M, Estrada N] Myeloid Neoplasms Group, Hematology Department, ICO Badalona-Hospital Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain. [Vélez P] Hematology Department, ICO Hospitalet-Hospital Duran y Reynals, l’Hospitalet de Llobregat, Spain. [Cortés M] Hospital General de Granollers, Granollers, Spain Hospital General de Granollers |
| dc.subject.none.fl_str_mv |
Leucèmia mieloide crònica Imatinib Anàlisi de supervivència (Biometria) DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myelogenous, Chronic, BCR-ABL Positive CHEMICALS AND DRUGS::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Survival Analysis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mielogenosa crónica BCR-ABL positiva COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::amidas::benzamidas::mesilato de imatinib TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis de supervivencia |
| topic |
Leucèmia mieloide crònica Imatinib Anàlisi de supervivència (Biometria) DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myelogenous, Chronic, BCR-ABL Positive CHEMICALS AND DRUGS::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Survival Analysis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mielogenosa crónica BCR-ABL positiva COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::amidas::benzamidas::mesilato de imatinib TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis de supervivencia |
| description |
Chronic myeloid leukemia; BCR-ABL1 transcripts; Response to imatinib |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/6532 http://hdl.handle.net/11351/6532 |
| url |
https://hdl.handle.net/11351/6532 http://hdl.handle.net/11351/6532 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Journal of Clinical Medicine;10(14) https://doi.org/10.3390/jcm10143146 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
| publisher.none.fl_str_mv |
MDPI |
| dc.source.none.fl_str_mv |
Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869403464141897728 |
| score |
15,811543 |