Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study

Background: Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. Objectives: To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrom...

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Autores: Sanchez-Luna, M, Medrano, C, Lirio, JL, Galiana G.G., Bernal, E.L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p6610
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6610
Access Level:acceso abierto
Palabra clave:Down syndrome
hospitalization
palivizumab
prospective birth cohort study
respiratory syncytial virus
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spelling Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological studySanchez-Luna, MMedrano, CLirio, JLGaliana G.G.Bernal, E.L.Down syndromehospitalizationpalivizumabprospective birth cohort studyrespiratory syncytial virusBackground: Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. Objectives: To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. Patients/Methods: In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (+/- 1 week) and were followed up to 1 year of age and during a complete RSV season. Results: The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non-DS cohort (44.1% vs 7.7%, P<.0001). Hospitalizations due to RSV were significantly more frequent in the DH cohort than in the non-DS cohort (9.7% vs 1.5%, P=.03). RSV prophylaxis was recorded in 33 (35.5%) infants with DS. The rate of hospitalization according to presence or absence of RSV immunoprophylaxis was 3.0% vs 15%, respectively. Conclusions: Infants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non-DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered.WILEY2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6610Influenza and Other Respiratory VirusesISSN: 17502640ISSNe: 17502659reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p66102026-06-14T12:41:47Z
dc.title.none.fl_str_mv Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
title Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
spellingShingle Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
Sanchez-Luna, M
Down syndrome
hospitalization
palivizumab
prospective birth cohort study
respiratory syncytial virus
title_short Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
title_full Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
title_fullStr Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
title_full_unstemmed Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
title_sort Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study
dc.creator.none.fl_str_mv Sanchez-Luna, M
Medrano, C
Lirio, JL
Galiana G.G.
Bernal, E.L.
author Sanchez-Luna, M
author_facet Sanchez-Luna, M
Medrano, C
Lirio, JL
Galiana G.G.
Bernal, E.L.
author_role author
author2 Medrano, C
Lirio, JL
Galiana G.G.
Bernal, E.L.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Down syndrome
hospitalization
palivizumab
prospective birth cohort study
respiratory syncytial virus
topic Down syndrome
hospitalization
palivizumab
prospective birth cohort study
respiratory syncytial virus
description Background: Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. Objectives: To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. Patients/Methods: In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (+/- 1 week) and were followed up to 1 year of age and during a complete RSV season. Results: The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non-DS cohort (44.1% vs 7.7%, P<.0001). Hospitalizations due to RSV were significantly more frequent in the DH cohort than in the non-DS cohort (9.7% vs 1.5%, P=.03). RSV prophylaxis was recorded in 33 (35.5%) infants with DS. The rate of hospitalization according to presence or absence of RSV immunoprophylaxis was 3.0% vs 15%, respectively. Conclusions: Infants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non-DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6610
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6610
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv Influenza and Other Respiratory Viruses
ISSN: 17502640
ISSNe: 17502659
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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