Down syndrome as risk factor for respiratory syncytial virus hospitalization

Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and...

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Detalhes bibliográficos
Autores: Sánchez Luna, Manuel, Medrano, Constancio, Lirio Casero, Julián, Suazo, José Antonio Hurtado, Peña, Manuela, López, Eduardo Narbona, Fernández, José Uberos, Jover, Enrique Blanca, Perales, Antonio Bonillo, Delgado, Javier Díes, Ortega Montes, María Ángeles, de la Cruz Moreno, Jesús, Ortiz Tardío, Joaquín, Esteban, María Victoria, Millán, Leticia, Salido Peracaula, Carlos, Quesada Trujillo, Gloria María, Martínez Pajares, José David, Lubián López, Simón Pedro, Ariza Aranda, Salvador, Faci Ventura, María Purificación, Valle Guillén, Sofía, Bueno Lozano, Olga, Rite Gracia, Segundo, García Cabezas, Miguel Ángel, Bejarano Ramírez, Natalia, Fresneda Machado, María Carmen, Martínez Gutiérrez, Andrés, Rellán Rodríguez, Sara, Marcos Temprano, Marianela, Ortega Vicente, Elena, Centeno Malfaz, Fernando|||0000-0002-4816-7649, San Feliciano Martín, Laura, Remesal Escalero, Ana, Benito Zaballos, Francisca, Closa-Monasterolo, Ricardo, Franch Salvadó, Silvia, Anquela Sanz, Israel Fernando, Bosch Castells, Joaquim, Trujillo Fagundo, Alberto, Ametller Malfaz, Emma, Sánchez Fernández, Mario José, Solé Mir, Eduard, Coroleu Lletget, Wifredo, Arroyo Carrera, Ignacio, Taboada Perianes, María, Couce Pico, María Luz, Fernández Seara, María José, Ruiz del Prado, María Yolanda, Poch Olive, María Luisa, Maderuelo, Elena, Zeballos, Susana, Leal Orozco, Ana, Ruíz Serrano, Cristina, Omeñaca, Félix, Escribano Palomino, Esperanza, García Guereta, Luis, Bosch Jiménez, Vicente, Gutiérrez Sánchez, José Diego, Cidrás Pidre, Manuel, Viguria Sánchez, Natividad, Goñi Orayen, Concepción, Aguirre Unceta-Barrenechea, Ana, Pérez Legorburu, Alberto, Palao Ortuño, María José, Giner Crespo, Maribel, González Muñoz, Ángel, Izquierdo Macián, María Isabel, Gómez Zafra, Rafael, Mayordomo Colunga, Juan, Montes Zapico, Bárbara, Rosón Varas, María, Mora Matilla, María, Oulego-Erróz, Ignacio, Prada Pereira, María Teresa, Arias Consuegra, Miguel Ángel, Castells Vilella, Laura, Mairal Cazcarra, Jesús Antonio, Yévenes Ruiz, Sílvia, Sáez Díez, Isabel, García Reymundo, Mercedes, Piñán López, Esther, Fernández Sarabia, Javier, Hernández Cáceres, Sofía, López Lois, María Gloria, Olivas, Cristina, Rivero Martín, María José, de las Heras Ibarra, Susana, Cuadrado, Mercedes, Ramos Amador, José Tomás, Guillén Martín, Sara, Cañete Díaz, Alfonso, Sopeña Corvino, Julia, González-Valcárcel Sánchez, Francisco Javier, Cambra Sirera, Jose, Pérez García, Begoña, Jiménez Candel, Maria Isabel, Cueto Calvo, Elisa, Guardia, Leonor, Ginovart, Gemma|||0000-0001-8072-1681, López Bernal, Ester, Sánchez de León, Lorenzo, Ferrandez, María Jesús, Quiles, Jose Luís, Rimblas, María, Larrosa Capaces, Susana
Formato: artículo
Fecha de publicación:2017
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289274
Acesso em linha:https://ddd.uab.cat/record/289274
https://dx.doi.org/urn:doi:10.1111/irv.12431
Access Level:acceso abierto
Palavra-chave:Down syndrome
Hospitalization
Palivizumab
Prospective birth cohort study
Respiratory syncytial virus
Descrição
Resumo:Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (±1 week) and were followed up to 1 year of age and during a complete RSV season. The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non-DS cohort (44.1% vs 7.7%, P<.0001). Hospitalizations due to RSV were significantly more frequent in the DH cohort than in the non-DS cohort (9.7% vs 1.5%, P=.03). RSV prophylaxis was recorded in 33 (35.5%) infants with DS. The rate of hospitalization according to presence or absence of RSV immunoprophylaxis was 3.0% vs 15%, respectively. Infants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non-DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered.

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