Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender

Background. Osteogenesis imperfecta (OI) is an inherited disorder characterized by bone fragility and skeletal alterations. The administration of bisphosphonates (BPs) to patients with OI reduces pain, thereby improving their quality of life. The main mechanism of action of BPs is the inhibition of...

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Autores: Garcete del Valle, Clara Sandibel, Nova García, Manuel Joaquín De, Mourelle Martínez, Rosa
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/108641
Acesso em linha:https://hdl.handle.net/20.500.14352/108641
Access Level:acceso abierto
Palavra-chave:616.314-053.2
615.849
616.71
Osteogenesis imperfecta
Bisphosphonates
Root resorption
Dental development
Premolar
Primary molar
Panoramic radiograph
Ciencias Biomédicas
Odontología infantil
Diagnóstico por imagen y medicina nuclear
32 Ciencias Médicas
3207.14 Osteopatología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/108641
network_acronym_str ES
network_name_str España
repository_id_str
spelling Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and genderGarcete del Valle, Clara SandibelNova García, Manuel Joaquín DeMourelle Martínez, Rosa616.314-053.2615.849616.71Osteogenesis imperfectaBisphosphonatesRoot resorptionDental developmentPremolarPrimary molarPanoramic radiographCiencias BiomédicasOdontología infantilDiagnóstico por imagen y medicina nuclear32 Ciencias Médicas3207.14 OsteopatologíaBackground. Osteogenesis imperfecta (OI) is an inherited disorder characterized by bone fragility and skeletal alterations. The administration of bisphosphonates (BPs) to patients with OI reduces pain, thereby improving their quality of life. The main mechanism of action of BPs is the inhibition of osteoclast action. In the oral cavity of children with OI during growth and development, physiological processes that require the function of osteoclasts occur. The aim of this investigation was to study the dental development of premolars and the root resorption of primary molars in children with OI medicated with BPs according to age and sex. Methods. An observational and analytical study was designed. The study sample consisted of 26 6- to 12-yearold children with a confirmed diagnosis of OI treated with BPs with available panoramic radiographs. The control group consisted of 395 children with available panoramic radiographs. Both groups were divided into subgroups according to sex and age. The third quadrant was studied, focusing on the first left temporary molar (7.4), the second left temporary molar (7.5), the first left permanent premolar (3.4) and the second left permanent premolar (3.5). The Demirjian method was used to study the dental development of 3.4 and 3.5, and the Haavikko method was used to study the root resorption of 7.4 and 7.5. The Mann‒Whitney U test was used for comparisons, and p<0.05 indicated statistical significance. Results The mean chronological age of the 421 patients was 9.21 years (95% CI 9.05–9.37). The sample was reasonably balanced by sex, with 52.5% (221 patients) boys versus 47.5% (200 patients) girls. Delayed exfoliation and tooth development were described in children with OI (p=0.05). According to sex, the root resorption of primary molars and tooth development were significantly lower in boys in both groups and in girls in the OI group, but the differences between the age groups were not significant. Conclusions Children with OI treated with BPs exhibit delayed dental development of the premolars and delayed root resorption of the primary molars. Boys exhibited delays in both variables, but the differences by age subgroup were not significant. These clinical findings support the importance of clinically and radiographically monitoring the dental development and root resorption of primary teeth in children with OI treated with BPs to avoid alterations of the eruptive processBMCUniversidad Complutense de Madrid20242024-07-2820242024-07-28journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/108641reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1086412026-06-02T12:44:21Z
dc.title.none.fl_str_mv Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender
title Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender
spellingShingle Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender
Garcete del Valle, Clara Sandibel
616.314-053.2
615.849
616.71
Osteogenesis imperfecta
Bisphosphonates
Root resorption
Dental development
Premolar
Primary molar
Panoramic radiograph
Ciencias Biomédicas
Odontología infantil
Diagnóstico por imagen y medicina nuclear
32 Ciencias Médicas
3207.14 Osteopatología
title_short Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender
title_full Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender
title_fullStr Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender
title_full_unstemmed Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender
title_sort Root resorption of primary molars and dental development of premolars in children with Osteogenesis Imperfecta medicated with bisphosphonates, grouped according to age and gender
dc.creator.none.fl_str_mv Garcete del Valle, Clara Sandibel
Nova García, Manuel Joaquín De
Mourelle Martínez, Rosa
author Garcete del Valle, Clara Sandibel
author_facet Garcete del Valle, Clara Sandibel
Nova García, Manuel Joaquín De
Mourelle Martínez, Rosa
author_role author
author2 Nova García, Manuel Joaquín De
Mourelle Martínez, Rosa
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.314-053.2
615.849
616.71
Osteogenesis imperfecta
Bisphosphonates
Root resorption
Dental development
Premolar
Primary molar
Panoramic radiograph
Ciencias Biomédicas
Odontología infantil
Diagnóstico por imagen y medicina nuclear
32 Ciencias Médicas
3207.14 Osteopatología
topic 616.314-053.2
615.849
616.71
Osteogenesis imperfecta
Bisphosphonates
Root resorption
Dental development
Premolar
Primary molar
Panoramic radiograph
Ciencias Biomédicas
Odontología infantil
Diagnóstico por imagen y medicina nuclear
32 Ciencias Médicas
3207.14 Osteopatología
description Background. Osteogenesis imperfecta (OI) is an inherited disorder characterized by bone fragility and skeletal alterations. The administration of bisphosphonates (BPs) to patients with OI reduces pain, thereby improving their quality of life. The main mechanism of action of BPs is the inhibition of osteoclast action. In the oral cavity of children with OI during growth and development, physiological processes that require the function of osteoclasts occur. The aim of this investigation was to study the dental development of premolars and the root resorption of primary molars in children with OI medicated with BPs according to age and sex. Methods. An observational and analytical study was designed. The study sample consisted of 26 6- to 12-yearold children with a confirmed diagnosis of OI treated with BPs with available panoramic radiographs. The control group consisted of 395 children with available panoramic radiographs. Both groups were divided into subgroups according to sex and age. The third quadrant was studied, focusing on the first left temporary molar (7.4), the second left temporary molar (7.5), the first left permanent premolar (3.4) and the second left permanent premolar (3.5). The Demirjian method was used to study the dental development of 3.4 and 3.5, and the Haavikko method was used to study the root resorption of 7.4 and 7.5. The Mann‒Whitney U test was used for comparisons, and p<0.05 indicated statistical significance. Results The mean chronological age of the 421 patients was 9.21 years (95% CI 9.05–9.37). The sample was reasonably balanced by sex, with 52.5% (221 patients) boys versus 47.5% (200 patients) girls. Delayed exfoliation and tooth development were described in children with OI (p=0.05). According to sex, the root resorption of primary molars and tooth development were significantly lower in boys in both groups and in girls in the OI group, but the differences between the age groups were not significant. Conclusions Children with OI treated with BPs exhibit delayed dental development of the premolars and delayed root resorption of the primary molars. Boys exhibited delays in both variables, but the differences by age subgroup were not significant. These clinical findings support the importance of clinically and radiographically monitoring the dental development and root resorption of primary teeth in children with OI treated with BPs to avoid alterations of the eruptive process
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-07-28
2024
2024-07-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/108641
url https://hdl.handle.net/20.500.14352/108641
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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