Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments

Purpose: The aim of this study was to assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal...

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Authors: Trujillo Guillen, Macarena|||0000-0003-4145-2188, Berjano, Enrique|||0000-0002-3247-2665, Castellvi, Quim, Burdío, Fernando, Sánchez Velázquez, Patricia, Ivorra, Antoni, Andaluz, Anna
Format: article
Publication Date:2013
Country:España
Institution:Universitat Politècnica de València (UPV)
Repository:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Language:English
OAI Identifier:oai:riunet.upv.es:10251/43198
Online Access:https://riunet.upv.es/handle/10251/43198
Access Level:Open access
Keyword:Tumour ablation
Radiofrequency ablation
In vivo model
Electroporation
MATEMATICA APLICADA
TECNOLOGIA ELECTRONICA
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spelling Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experimentsTrujillo Guillen, Macarena|||0000-0003-4145-2188Berjano, Enrique|||0000-0002-3247-2665Castellvi, QuimBurdío, FernandoSánchez Velázquez, PatriciaIvorra, AntoniAndaluz, AnnaTumour ablationRadiofrequency ablationIn vivo modelElectroporationMATEMATICA APLICADATECNOLOGIA ELECTRONICAPurpose: The aim of this study was to assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal sink effect and hence to increase the coagulation volume in comparison to that created exclusively by RFA. Materials and methods: A modelling study and in vivo experimental study were used. A Cool-tip RF applicator was used both for EP and RFA. Results: Overall, the results did not show any synergy effect from using the hybrid technique. Applying EP pulses prior to RFA did not increase the coagulation zone obtained and the lesions were almost identical. Additional computer simulations provided an explanation for this; the effect of reducing blood perfusion by thermal damage during RFA completely masks the effect of reducing blood perfusion by EP. This is because both thermal damage and EP affect the same zone, i.e. the tissue around the electrode. Conclusions: Our computer modelling and in vivo experimental findings suggest that the combination of EP and RFA with monopolar applicators does not provide an additional benefit over the use of RFA alone.This work received financial support from the Spanish 'Plan Nacional de I + D + I del Ministerio de Ciencia e Innovacion' Grant nos. TEC2011-27133-C02-01,02 and TEC2010-17285, from the European Commission through the Marie Curie IRG grant TAMIVIVE (256376) and from the Universitat Politecnica de Valencia (INNOVA11-01-5502; and PAID-06-11 Ref. 1988). The linguistic revision of this paper was funded by the Universitat Politecnica de Valencia, Spain. The authors alone are responsible for the content and writing of the paper.Informa HealthcareDepartamento de Ingeniería ElectrónicaDepartamento de Matemática AplicadaEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialEscuela Técnica Superior de ArquitecturaBiosignals & Minimally Invasive Technologies-BioMITUniversitat Politècnica de ValènciaRepositorio Institucional de la Universitat Politècnica de València Riunet20132013-05-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/43198reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 TEC2010-17285 METODOS Y HERRAMIENTAS PARA LA ELECTROPORACION IN VIVOUniversitat Politècnica de València https://doi.org/10.13039/501100004233 PAID-06-11-1988Universitat Politècnica de València https://doi.org/10.13039/501100004233 INNOVA11-01- 5502Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 TEC2011-27133-C02-01 MODELADO TEORICO Y EXPERIMENTACION PARA TECNICAS ABLATIVAS BASADAS EN ENERGIAMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 TEC2011-27133-C02-02 EXPERIMENTACION PARA TECNICAS ABLATIVAS BASADAS EN ENERGIAEuropean Commission https://doi.org/10.13039/501100000780 FP7 256376 Tools and methods for in vivo electroporationopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/431982026-06-13T07:49:27Z
dc.title.none.fl_str_mv Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
spellingShingle Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
Trujillo Guillen, Macarena|||0000-0003-4145-2188
Tumour ablation
Radiofrequency ablation
In vivo model
Electroporation
MATEMATICA APLICADA
TECNOLOGIA ELECTRONICA
title_short Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title_full Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title_fullStr Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title_full_unstemmed Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
title_sort Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
dc.creator.none.fl_str_mv Trujillo Guillen, Macarena|||0000-0003-4145-2188
Berjano, Enrique|||0000-0002-3247-2665
Castellvi, Quim
Burdío, Fernando
Sánchez Velázquez, Patricia
Ivorra, Antoni
Andaluz, Anna
author Trujillo Guillen, Macarena|||0000-0003-4145-2188
author_facet Trujillo Guillen, Macarena|||0000-0003-4145-2188
Berjano, Enrique|||0000-0002-3247-2665
Castellvi, Quim
Burdío, Fernando
Sánchez Velázquez, Patricia
Ivorra, Antoni
Andaluz, Anna
author_role author
author2 Berjano, Enrique|||0000-0002-3247-2665
Castellvi, Quim
Burdío, Fernando
Sánchez Velázquez, Patricia
Ivorra, Antoni
Andaluz, Anna
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería Electrónica
Departamento de Matemática Aplicada
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Escuela Técnica Superior de Arquitectura
Biosignals & Minimally Invasive Technologies-BioMIT
Universitat Politècnica de València
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Tumour ablation
Radiofrequency ablation
In vivo model
Electroporation
MATEMATICA APLICADA
TECNOLOGIA ELECTRONICA
topic Tumour ablation
Radiofrequency ablation
In vivo model
Electroporation
MATEMATICA APLICADA
TECNOLOGIA ELECTRONICA
description Purpose: The aim of this study was to assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal sink effect and hence to increase the coagulation volume in comparison to that created exclusively by RFA. Materials and methods: A modelling study and in vivo experimental study were used. A Cool-tip RF applicator was used both for EP and RFA. Results: Overall, the results did not show any synergy effect from using the hybrid technique. Applying EP pulses prior to RFA did not increase the coagulation zone obtained and the lesions were almost identical. Additional computer simulations provided an explanation for this; the effect of reducing blood perfusion by thermal damage during RFA completely masks the effect of reducing blood perfusion by EP. This is because both thermal damage and EP affect the same zone, i.e. the tissue around the electrode. Conclusions: Our computer modelling and in vivo experimental findings suggest that the combination of EP and RFA with monopolar applicators does not provide an additional benefit over the use of RFA alone.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-05-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/43198
url https://riunet.upv.es/handle/10251/43198
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 TEC2010-17285 METODOS Y HERRAMIENTAS PARA LA ELECTROPORACION IN VIVO
Universitat Politècnica de València https://doi.org/10.13039/501100004233 PAID-06-11-1988
Universitat Politècnica de València https://doi.org/10.13039/501100004233 INNOVA11-01- 5502
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 TEC2011-27133-C02-01 MODELADO TEORICO Y EXPERIMENTACION PARA TECNICAS ABLATIVAS BASADAS EN ENERGIA
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 TEC2011-27133-C02-02 EXPERIMENTACION PARA TECNICAS ABLATIVAS BASADAS EN ENERGIA
European Commission https://doi.org/10.13039/501100000780 FP7 256376 Tools and methods for in vivo electroporation
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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