Cross-Dehydrogenative Coupling Reactions for the Functionalization of α-Amino Acid Derivatives and Peptides
The functionalization of typically unreactive C(sp3)–H bondsholds great promise for reducing the reliance on existing functionalgroups while improving atom-economy and energy efficiency. As a re-sult, this topic is a matter of genuine concern for scientists in order toachieve greener chemical proces...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad del País Vasco |
| Repositorio: | Addi. Archivo Digital para la Docencia y la Investigación |
| OAI Identifier: | oai:addi.ehu.eus:10810/36647 |
| Acceso en línea: | http://hdl.handle.net/10810/36647 |
| Access Level: | acceso abierto |
| Palabra clave: | cross-dehydrogenative coupling peptide α-amino acid oxidative C–H functionalization |
| Sumario: | The functionalization of typically unreactive C(sp3)–H bondsholds great promise for reducing the reliance on existing functionalgroups while improving atom-economy and energy efficiency. As a re-sult, this topic is a matter of genuine concern for scientists in order toachieve greener chemical processes. The site-specific modification of α-amino acid and peptides based upon C(sp3)–H functionalization stillrepresents a great challenge of utmost synthetic importance. This shortreview summarizes the most recent advances in ‘Cross-Dehydrogenative Couplings’ of α-amino carbonyl compounds and peptide derivativeswith a variety of nucleophilic coupling partners. |
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