Iron-Catalyzed Stereoselective C–H Acylation of 2-Acetamido Acrylates
An iron-catalyzed oxidative acylation of acylamido acrylates with abundant aldehydes has been developed. The use of mono N-protected amino acids results in the unusual assembly of α,β-unsaturated compounds in a predictable (Z)-stereoselective fashion, thereby offering a complementary tool toward the...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad del País Vasco |
| Repositorio: | Addi. Archivo Digital para la Docencia y la Investigación |
| OAI Identifier: | oai:addi.ehu.eus:10810/74829 |
| Acceso en línea: | http://hdl.handle.net/10810/74829 |
| Access Level: | acceso abierto |
| Palabra clave: | acylation amino acid cross-dehydrogenative coupling dehydroalanine C–H functionalization |
| Sumario: | An iron-catalyzed oxidative acylation of acylamido acrylates with abundant aldehydes has been developed. The use of mono N-protected amino acids results in the unusual assembly of α,β-unsaturated compounds in a predictable (Z)-stereoselective fashion, thereby offering a complementary tool toward the synthesis of unnatural γ-carbonyl α-amino acid derivatives. Density functional theory studies provide insights into the stereodetermining step of the radical reaction pathway |
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