Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. Here we report a si...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:236240 |
| Acceso en línea: | https://ddd.uab.cat/record/236240 https://dx.doi.org/urn:doi:10.1002/jev2.12046 |
| Access Level: | acceso abierto |
| Palabra clave: | Extracellular vesicles HIV-1 Mtb Siglec-1 |
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oai:ddd.uab.cat:236240 |
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España |
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| dc.title.none.fl_str_mv |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles |
| title |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles |
| spellingShingle |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles Benet, Susana|||0000-0002-2219-8826 Extracellular vesicles HIV-1 Mtb Siglec-1 |
| title_short |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles |
| title_full |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles |
| title_fullStr |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles |
| title_full_unstemmed |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles |
| title_sort |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles |
| dc.creator.none.fl_str_mv |
Benet, Susana|||0000-0002-2219-8826 Gálvez, Cristina|||0000-0002-2286-6193 Drobniewski, Francis Kontsevaya, Irina Arias, Lilibeth|||0000-0002-2469-8832 Monguió-Tortajada, Marta|||0000-0003-2125-0810 Erkizia, Itziar|||0000-0003-1244-8972 Urrea, Víctor|||0000-0002-2577-856X Ong, Ruo-Yan Luquin Fernandez, Marina de la Milagrosa|||0000-0002-6015-3282 Dupont, Maeva|||0000-0002-0514-4447 Chojnacki, Jakub|||0000-0002-4457-8096 Dalmau, Judith|||0000-0001-7513-3711 Cardona, Paula|||0000-0002-8613-9390 Neyrolles, Olivier|||0000-0003-0047-5885 Lugo-Villarino, Geanncarlo|||0000-0003-4620-8491 Vérollet, Christel|||0000-0002-1079-9085 Julián Gómez, Esther|||0000-0002-6558-3978 Furrer, Hansjakob Günthard, Huldrych F. Crocker, Paul R. Tapia, Gustavo|||0000-0003-1882-0368 Borràs i Serres, Francesc Enric|||0000-0003-4038-1912 Fellay, Jacques|||0000-0002-8240-939X McLaren, Paul J. Telenti, Amalio Cardona, Pere-Joan|||0000-0001-5623-7873 Pérez-Álvarez, Núria|||0000-0001-6582-1553 Vilaplana Massaguer, Cristina|||0000-0002-2808-7270 Martínez Picado, Francisco Javier|||0000-0002-4916-2129 Izquierdo Useros, Nuria|||0000-0002-1039-1821 |
| author |
Benet, Susana|||0000-0002-2219-8826 |
| author_facet |
Benet, Susana|||0000-0002-2219-8826 Gálvez, Cristina|||0000-0002-2286-6193 Drobniewski, Francis Kontsevaya, Irina Arias, Lilibeth|||0000-0002-2469-8832 Monguió-Tortajada, Marta|||0000-0003-2125-0810 Erkizia, Itziar|||0000-0003-1244-8972 Urrea, Víctor|||0000-0002-2577-856X Ong, Ruo-Yan Luquin Fernandez, Marina de la Milagrosa|||0000-0002-6015-3282 Dupont, Maeva|||0000-0002-0514-4447 Chojnacki, Jakub|||0000-0002-4457-8096 Dalmau, Judith|||0000-0001-7513-3711 Cardona, Paula|||0000-0002-8613-9390 Neyrolles, Olivier|||0000-0003-0047-5885 Lugo-Villarino, Geanncarlo|||0000-0003-4620-8491 Vérollet, Christel|||0000-0002-1079-9085 Julián Gómez, Esther|||0000-0002-6558-3978 Furrer, Hansjakob Günthard, Huldrych F. Crocker, Paul R. Tapia, Gustavo|||0000-0003-1882-0368 Borràs i Serres, Francesc Enric|||0000-0003-4038-1912 Fellay, Jacques|||0000-0002-8240-939X McLaren, Paul J. Telenti, Amalio Cardona, Pere-Joan|||0000-0001-5623-7873 Pérez-Álvarez, Núria|||0000-0001-6582-1553 Vilaplana Massaguer, Cristina|||0000-0002-2808-7270 Martínez Picado, Francisco Javier|||0000-0002-4916-2129 Izquierdo Useros, Nuria|||0000-0002-1039-1821 |
| author_role |
author |
| author2 |
Gálvez, Cristina|||0000-0002-2286-6193 Drobniewski, Francis Kontsevaya, Irina Arias, Lilibeth|||0000-0002-2469-8832 Monguió-Tortajada, Marta|||0000-0003-2125-0810 Erkizia, Itziar|||0000-0003-1244-8972 Urrea, Víctor|||0000-0002-2577-856X Ong, Ruo-Yan Luquin Fernandez, Marina de la Milagrosa|||0000-0002-6015-3282 Dupont, Maeva|||0000-0002-0514-4447 Chojnacki, Jakub|||0000-0002-4457-8096 Dalmau, Judith|||0000-0001-7513-3711 Cardona, Paula|||0000-0002-8613-9390 Neyrolles, Olivier|||0000-0003-0047-5885 Lugo-Villarino, Geanncarlo|||0000-0003-4620-8491 Vérollet, Christel|||0000-0002-1079-9085 Julián Gómez, Esther|||0000-0002-6558-3978 Furrer, Hansjakob Günthard, Huldrych F. Crocker, Paul R. Tapia, Gustavo|||0000-0003-1882-0368 Borràs i Serres, Francesc Enric|||0000-0003-4038-1912 Fellay, Jacques|||0000-0002-8240-939X McLaren, Paul J. Telenti, Amalio Cardona, Pere-Joan|||0000-0001-5623-7873 Pérez-Álvarez, Núria|||0000-0001-6582-1553 Vilaplana Massaguer, Cristina|||0000-0002-2808-7270 Martínez Picado, Francisco Javier|||0000-0002-4916-2129 Izquierdo Useros, Nuria|||0000-0002-1039-1821 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Extracellular vesicles HIV-1 Mtb Siglec-1 |
| topic |
Extracellular vesicles HIV-1 Mtb Siglec-1 |
| description |
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. Here we report a significant association between the SIGLEC1 null variant and extrapulmonary dissemination of Mycobacterium tuberculosis (Mtb) in two clinical cohorts comprising 6,256 individuals. Local spread of bacteria within the lung is apparent in Mtb-infected Siglec-1 knockout mice which, despite having similar bacterial load, developed more extensive lesions compared to wild type mice. We find that Siglec-1 is necessary to induce antigen presentation through extracellular vesicle uptake. We postulate that lack of Siglec-1 delays the onset of protective immunity against Mtb by limiting antigen exchange via extracellular vesicles, allowing for an early local spread of mycobacteria that increases the risk for extrapulmonary dissemination. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/236240 https://dx.doi.org/urn:doi:10.1002/jev2.12046 |
| url |
https://ddd.uab.cat/record/236240 https://dx.doi.org/urn:doi:10.1002/jev2.12046 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2016-80033-R Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-109870RB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-252 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM17-00242 Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU15-03698 European Commission https://doi.org/10.13039/501100000780 825673 European Commission https://doi.org/10.13039/501100000780 733079 European Commission https://doi.org/10.13039/501100000780 793830 European Commission https://doi.org/10.13039/501100000780 643381 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 IFI14-00015 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII18-00031 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-500 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-301 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-483 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-229 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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1869403355317534720 |
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Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesiclesBenet, Susana|||0000-0002-2219-8826Gálvez, Cristina|||0000-0002-2286-6193Drobniewski, FrancisKontsevaya, IrinaArias, Lilibeth|||0000-0002-2469-8832Monguió-Tortajada, Marta|||0000-0003-2125-0810Erkizia, Itziar|||0000-0003-1244-8972Urrea, Víctor|||0000-0002-2577-856XOng, Ruo-YanLuquin Fernandez, Marina de la Milagrosa|||0000-0002-6015-3282Dupont, Maeva|||0000-0002-0514-4447Chojnacki, Jakub|||0000-0002-4457-8096Dalmau, Judith|||0000-0001-7513-3711Cardona, Paula|||0000-0002-8613-9390Neyrolles, Olivier|||0000-0003-0047-5885Lugo-Villarino, Geanncarlo|||0000-0003-4620-8491Vérollet, Christel|||0000-0002-1079-9085Julián Gómez, Esther|||0000-0002-6558-3978Furrer, HansjakobGünthard, Huldrych F.Crocker, Paul R.Tapia, Gustavo|||0000-0003-1882-0368Borràs i Serres, Francesc Enric|||0000-0003-4038-1912Fellay, Jacques|||0000-0002-8240-939XMcLaren, Paul J.Telenti, AmalioCardona, Pere-Joan|||0000-0001-5623-7873Pérez-Álvarez, Núria|||0000-0001-6582-1553Vilaplana Massaguer, Cristina|||0000-0002-2808-7270Martínez Picado, Francisco Javier|||0000-0002-4916-2129Izquierdo Useros, Nuria|||0000-0002-1039-1821Extracellular vesiclesHIV-1MtbSiglec-1The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. Here we report a significant association between the SIGLEC1 null variant and extrapulmonary dissemination of Mycobacterium tuberculosis (Mtb) in two clinical cohorts comprising 6,256 individuals. Local spread of bacteria within the lung is apparent in Mtb-infected Siglec-1 knockout mice which, despite having similar bacterial load, developed more extensive lesions compared to wild type mice. We find that Siglec-1 is necessary to induce antigen presentation through extracellular vesicle uptake. We postulate that lack of Siglec-1 delays the onset of protective immunity against Mtb by limiting antigen exchange via extracellular vesicles, allowing for an early local spread of mycobacteria that increases the risk for extrapulmonary dissemination. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/236240https://dx.doi.org/urn:doi:10.1002/jev2.12046reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2016-80033-RAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-109870RB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-252Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM17-00242Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU15-03698European Commission https://doi.org/10.13039/501100000780 825673European Commission https://doi.org/10.13039/501100000780 733079European Commission https://doi.org/10.13039/501100000780 793830European Commission https://doi.org/10.13039/501100000780 643381Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 IFI14-00015Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII18-00031Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-500Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-301Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-483Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-229open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2362402026-06-06T12:50:31Z |
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15.301603 |