Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems

Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by robust burning and eczematous lacerations in diverse portions of the body. AD affects about 20% of both offspring and adults worldwide. The pathophysiology of AD combines environmental, heredit...

Descripción completa

Detalles Bibliográficos
Autores: Souto, Eliana B., Dias-Ferreira, João, Oliveira, Jéssica, Sánchez-López, E. (Elena), López-Machado, Ana, Espina García, Marta, García, Maria Luisa, Souto, Selma B., Martins-Gomes, Carlos, Silva, Amélia M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/145517
Acceso en línea:https://hdl.handle.net/2445/145517
Access Level:acceso abierto
Palabra clave:Dermatitis atòpica
Sistemes d'administració de medicaments
Nanopartícules
Nanotecnologia
Atopic dermatitis
Drug delivery devices
Nanoparticles
Nanotechnology
id ES_0d9dfabd89d8c00a7c0063630e75ef00
oai_identifier_str oai:recercat.cat:2445/145517
network_acronym_str ES
network_name_str España
repository_id_str
spelling Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery SystemsSouto, Eliana B.Dias-Ferreira, JoãoOliveira, JéssicaSánchez-López, E. (Elena)López-Machado, AnaEspina García, MartaGarcía, Maria LuisaSouto, Selma B.Martins-Gomes, CarlosSilva, Amélia M.Dermatitis atòpicaSistemes d'administració de medicamentsNanopartículesNanotecnologiaAtopic dermatitisDrug delivery devicesNanoparticlesNanotechnologyAtopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by robust burning and eczematous lacerations in diverse portions of the body. AD affects about 20% of both offspring and adults worldwide. The pathophysiology of AD combines environmental, hereditary, and immunological aspects, together with skin barrier dysfunction. The procedures used to prevent the disease are the everyday usage of creams to support the restoration of the epidermal barrier. The classical treatments include the use of topical corticosteroids as a first-line therapy, but also calcineurin inhibitors, antihistamines, antibiotics, phototherapy, and also immunosuppressant drugs in severe cases of AD. Topical drug delivery to deeper skin layers is a difficult task due to the skin anatomic barrier, which limits deeper penetration of drugs. Groundbreaking drug delivery systems, based on nanoparticles (NPs), have received much attention due to their ability to improve solubility, bioavailability, diffusion, targeting to specific types of cells, and limiting the secondary effects of the drugs employed in the treatment of AD. Even so, additional studies are still required to recognize the toxicological characteristics and long-term safety of NPs. This review discusses the current classical pharmacotherapy of AD against new nanoparticle skin delivery systems and their toxicologic risks. KEYWORDS: atopic dermatitis; drug delivery systems; nanoparticles; nanotechnology; pharmacological treatmentMDPI2019201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/145517Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms20225659International Journal of Molecular Sciences, 2019, vol. 20, p. 5659https://doi.org/10.3390/ijms20225659cc-by (c) Souto, Eliana B. et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1455172026-05-29T05:05:01Z
dc.title.none.fl_str_mv Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems
title Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems
spellingShingle Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems
Souto, Eliana B.
Dermatitis atòpica
Sistemes d'administració de medicaments
Nanopartícules
Nanotecnologia
Atopic dermatitis
Drug delivery devices
Nanoparticles
Nanotechnology
title_short Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems
title_full Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems
title_fullStr Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems
title_full_unstemmed Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems
title_sort Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems
dc.creator.none.fl_str_mv Souto, Eliana B.
Dias-Ferreira, João
Oliveira, Jéssica
Sánchez-López, E. (Elena)
López-Machado, Ana
Espina García, Marta
García, Maria Luisa
Souto, Selma B.
Martins-Gomes, Carlos
Silva, Amélia M.
author Souto, Eliana B.
author_facet Souto, Eliana B.
Dias-Ferreira, João
Oliveira, Jéssica
Sánchez-López, E. (Elena)
López-Machado, Ana
Espina García, Marta
García, Maria Luisa
Souto, Selma B.
Martins-Gomes, Carlos
Silva, Amélia M.
author_role author
author2 Dias-Ferreira, João
Oliveira, Jéssica
Sánchez-López, E. (Elena)
López-Machado, Ana
Espina García, Marta
García, Maria Luisa
Souto, Selma B.
Martins-Gomes, Carlos
Silva, Amélia M.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dermatitis atòpica
Sistemes d'administració de medicaments
Nanopartícules
Nanotecnologia
Atopic dermatitis
Drug delivery devices
Nanoparticles
Nanotechnology
topic Dermatitis atòpica
Sistemes d'administració de medicaments
Nanopartícules
Nanotecnologia
Atopic dermatitis
Drug delivery devices
Nanoparticles
Nanotechnology
description Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by robust burning and eczematous lacerations in diverse portions of the body. AD affects about 20% of both offspring and adults worldwide. The pathophysiology of AD combines environmental, hereditary, and immunological aspects, together with skin barrier dysfunction. The procedures used to prevent the disease are the everyday usage of creams to support the restoration of the epidermal barrier. The classical treatments include the use of topical corticosteroids as a first-line therapy, but also calcineurin inhibitors, antihistamines, antibiotics, phototherapy, and also immunosuppressant drugs in severe cases of AD. Topical drug delivery to deeper skin layers is a difficult task due to the skin anatomic barrier, which limits deeper penetration of drugs. Groundbreaking drug delivery systems, based on nanoparticles (NPs), have received much attention due to their ability to improve solubility, bioavailability, diffusion, targeting to specific types of cells, and limiting the secondary effects of the drugs employed in the treatment of AD. Even so, additional studies are still required to recognize the toxicological characteristics and long-term safety of NPs. This review discusses the current classical pharmacotherapy of AD against new nanoparticle skin delivery systems and their toxicologic risks. KEYWORDS: atopic dermatitis; drug delivery systems; nanoparticles; nanotechnology; pharmacological treatment
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/145517
url https://hdl.handle.net/2445/145517
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms20225659
International Journal of Molecular Sciences, 2019, vol. 20, p. 5659
https://doi.org/10.3390/ijms20225659
dc.rights.none.fl_str_mv cc-by (c) Souto, Eliana B. et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Souto, Eliana B. et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403349976088576
score 15.812429

Similares en LA Referencia