[Translated article] Clinical-Epidemiological Profile, and Treatment Response in Relation to Associated Atopic Comorbidity in Atopic Dermatitis. Experience From the BIOBADATOP Registry.

BACKGROUND: Despite advances made in treatments for atopic dermatitis (AD), information on its impact and interaction with atopic comorbidities, such as asthma, rhinoconjunctivitis, and ocular disease is limited. This study aims to assess the clinical-epidemiological characteristics of patients with...

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Autores: Peris-Espino V, Munera-Campos M, Chicharro P, González Quesada A, Flórez Menéndez Á, de la Cueva Dobao P, Giménez Arnau AM, Gilaberte Calzada Y, Rodríguez Serna M, Montero-Vilchez T, Silvestre Salvador JF, Ruiz-Villaverde R, Elosua-González M, Del Alcázar-Viladomiu E, Sánchez-Pérez J, Carretero Hernández G, Batalla A, Suh Oh HJ, Couselo-Rodríguez C, Mauleón Fernández C, Curto-Barredo L, Bertolín-Colilla M, Navarro-Bielsa A, Ballano Ruiz A, Botella Estrada R, Arias-Santiago S, Sanabria-de-la-Torre R, Betlloch-Mas I, Navarro-Triviño FJ, Roustan Gullón G, Rosell-Díaz A, Loro-Pérez M, Suárez-Pérez J, García-Doval I, Descalzo-Gallego MÁ, Carrascosa Carrillo JM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p11150
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones11150
https://www.actasdermo.org/en-linkresolver-clinicalepidemiological-profile-treatment-response-S000173102500064X
Access Level:acceso abierto
Palabra clave:Atopic comorbidities
Atopic dermatitis
Cohorte prospectiva
Comorbilidades atópicas
Dermatitis atópica
Prospective cohort
Tratamientos
Treatments
Descripción
Sumario:BACKGROUND: Despite advances made in treatments for atopic dermatitis (AD), information on its impact and interaction with atopic comorbidities, such as asthma, rhinoconjunctivitis, and ocular disease is limited. This study aims to assess the clinical-epidemiological characteristics of patients with AD - treatment response included - while taking into consideration atopic comorbidities like these. MATERIALS AND METHODS: Data were analyzed from the multicenter BIOBADATOP registry (a prospective cohort of AD patients initiating systemic treatment). We conducted a descriptive analysis of the main characteristics collected in the registry in relation to atopic comorbidity. RESULTS: We included a total of 509 patients, mostly adults (81.9%) with severe AD (73.7%). Patients with personal atopic comorbidity (64%) more frequently exhibited flexural dermatitis (89.7% vs. 81.5%), a higher mean of previous systemic treatments (1.6 vs. 1.3), and higher baseline values on the POEM scale (19.6 vs. 17.9). Patients with familial atopic comorbidity (40.7%) had a higher incidence of pediatric/adolescent patients (24.2% vs. 13.9%) and a history of allergic rhinoconjunctivitis (61.1% vs. 47.1%). No differences regarding treatment response were observed at the 6- and 12-month follow-ups based on the presence or absence of atopic comorbidities. CONCLUSIONS: Results suggest that a history of atopic comorbidity is associated with an early onset and persistent course of AD. Although no differences were reported in the short-term treatment response, further follow-up is required to better understand the impact of comorbidities on AD.

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