Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat
The aim of this study is to assess the long-term effect of mesenchymal stem cells (MSC) transplantation in a rat model of chronic myocardial infarction (MI) in comparison with the effect of bone marrow mononuclear cells (BM-MNC) transplant. Five weeks after induction of MI, rats were allocated to re...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2009 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/13519 |
| Acceso en línea: | https://hdl.handle.net/10171/13519 |
| Access Level: | acceso abierto |
| Palabra clave: | Bone marrow stem cells Angiogenesis Chronic myocardial infarction Cardiac remodeling Área de Terapia Celular |
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Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in ratMazo-Vega, M.M. (Manuel María)|||/items/c871e8d9-ee5d-487b-97ef-7302feb8a02eGavira-Gómez, J.J. (Juan José)|||/items/a253ead5-4ef7-4b80-9aab-43b47605270eAbizanda-Sarasa, G. (Gloria)|||/items/1e76a0e3-32d0-424e-b58a-d9ddf7a82ef7Moreno-Parado, C. (Cristina)|||/items/057396d1-cf8a-4676-91fc-9100b0169390Ecay, M. (Margarita)|||/items/62075174-6491-4648-a96e-d724a641d353Soriano, M. (Mario)|||/items/8eae3369-3c62-4ccc-8247-03ae93b9a559Aranda, P. (P.)|||/items/92ca618c-acbf-4ecc-99dc-498fe5af2078Collantes, M. (María)|||/items/102ad3e7-3f57-4958-8e97-39af1c92626bAlegria, E. (Eduardo)|||/items/66783cb2-c3ec-4c12-bed5-74d89aafeef0Merino, J. (Juana)|||/items/e1c30c26-556a-42b9-adf9-aaae7bb3b425Peñuelas-Sanchez, I. (Ivan)|||/items/7022e2fa-b3b0-48ed-8d39-2020cfae85a4Garcia-Verdugo, J.M. (José Manuel)|||/items/06bcbe24-fc30-4c80-9f45-6264207191baPelacho-Samper, B. (Beatriz)|||/items/aca35c0e-183d-435d-9d44-1888e0854ff3Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1Bone marrow stem cellsAngiogenesisChronic myocardial infarctionCardiac remodelingÁrea de Terapia CelularThe aim of this study is to assess the long-term effect of mesenchymal stem cells (MSC) transplantation in a rat model of chronic myocardial infarction (MI) in comparison with the effect of bone marrow mononuclear cells (BM-MNC) transplant. Five weeks after induction of MI, rats were allocated to receive intramyocardial injection of 106 GFP-expressing cells (BM-MNC or MSC) or medium as control. Heart function (echocardiography and 18F-FDG-microPET) and histological studies were performed 3 months after transplantation and cell fate was analyzed along the experiment (1 and 2 weeks and 1 and 3 months). The main findings of this study were that both BM-derived populations, BM-MNC and MSC, induced a long-lasting (3 months) improvement in LVEF (BM-MNC: 26.61 ± 2.01% to 46.61 ± 3.7%, p < 0.05; MSC: 27.5 ± 1.28% to 38.8 ± 3.2%, p < 0.05) but remarkably, only MSC improved tissue metabolism quantified by 18FFDG uptake (71.15 ± 1.27 to 76.31 ± 1.11, p < 0.01), which was thereby associated with a smaller infarct size and scar collagen content and also with a higher revascularization degree. Altogether, results show that MSC provides a long-term superior benefit than whole BM-MNC transplantation in a rat model of chronic MI.Cognizant Communication CorporationDadun. Depósito Académico Digital Universidad de Navarra20102010-10-1920092009-11-0120092009-11-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/13519reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/135192026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat |
| title |
Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat |
| spellingShingle |
Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat Mazo-Vega, M.M. (Manuel María)|||/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e Bone marrow stem cells Angiogenesis Chronic myocardial infarction Cardiac remodeling Área de Terapia Celular |
| title_short |
Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat |
| title_full |
Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat |
| title_fullStr |
Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat |
| title_full_unstemmed |
Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat |
| title_sort |
Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat |
| dc.creator.none.fl_str_mv |
Mazo-Vega, M.M. (Manuel María)|||/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e Gavira-Gómez, J.J. (Juan José)|||/items/a253ead5-4ef7-4b80-9aab-43b47605270e Abizanda-Sarasa, G. (Gloria)|||/items/1e76a0e3-32d0-424e-b58a-d9ddf7a82ef7 Moreno-Parado, C. (Cristina)|||/items/057396d1-cf8a-4676-91fc-9100b0169390 Ecay, M. (Margarita)|||/items/62075174-6491-4648-a96e-d724a641d353 Soriano, M. (Mario)|||/items/8eae3369-3c62-4ccc-8247-03ae93b9a559 Aranda, P. (P.)|||/items/92ca618c-acbf-4ecc-99dc-498fe5af2078 Collantes, M. (María)|||/items/102ad3e7-3f57-4958-8e97-39af1c92626b Alegria, E. (Eduardo)|||/items/66783cb2-c3ec-4c12-bed5-74d89aafeef0 Merino, J. (Juana)|||/items/e1c30c26-556a-42b9-adf9-aaae7bb3b425 Peñuelas-Sanchez, I. (Ivan)|||/items/7022e2fa-b3b0-48ed-8d39-2020cfae85a4 Garcia-Verdugo, J.M. (José Manuel)|||/items/06bcbe24-fc30-4c80-9f45-6264207191ba Pelacho-Samper, B. (Beatriz)|||/items/aca35c0e-183d-435d-9d44-1888e0854ff3 Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 |
| author |
Mazo-Vega, M.M. (Manuel María)|||/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e |
| author_facet |
Mazo-Vega, M.M. (Manuel María)|||/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e Gavira-Gómez, J.J. (Juan José)|||/items/a253ead5-4ef7-4b80-9aab-43b47605270e Abizanda-Sarasa, G. (Gloria)|||/items/1e76a0e3-32d0-424e-b58a-d9ddf7a82ef7 Moreno-Parado, C. (Cristina)|||/items/057396d1-cf8a-4676-91fc-9100b0169390 Ecay, M. (Margarita)|||/items/62075174-6491-4648-a96e-d724a641d353 Soriano, M. (Mario)|||/items/8eae3369-3c62-4ccc-8247-03ae93b9a559 Aranda, P. (P.)|||/items/92ca618c-acbf-4ecc-99dc-498fe5af2078 Collantes, M. (María)|||/items/102ad3e7-3f57-4958-8e97-39af1c92626b Alegria, E. (Eduardo)|||/items/66783cb2-c3ec-4c12-bed5-74d89aafeef0 Merino, J. (Juana)|||/items/e1c30c26-556a-42b9-adf9-aaae7bb3b425 Peñuelas-Sanchez, I. (Ivan)|||/items/7022e2fa-b3b0-48ed-8d39-2020cfae85a4 Garcia-Verdugo, J.M. (José Manuel)|||/items/06bcbe24-fc30-4c80-9f45-6264207191ba Pelacho-Samper, B. (Beatriz)|||/items/aca35c0e-183d-435d-9d44-1888e0854ff3 Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 |
| author_role |
author |
| author2 |
Gavira-Gómez, J.J. (Juan José)|||/items/a253ead5-4ef7-4b80-9aab-43b47605270e Abizanda-Sarasa, G. (Gloria)|||/items/1e76a0e3-32d0-424e-b58a-d9ddf7a82ef7 Moreno-Parado, C. (Cristina)|||/items/057396d1-cf8a-4676-91fc-9100b0169390 Ecay, M. (Margarita)|||/items/62075174-6491-4648-a96e-d724a641d353 Soriano, M. (Mario)|||/items/8eae3369-3c62-4ccc-8247-03ae93b9a559 Aranda, P. (P.)|||/items/92ca618c-acbf-4ecc-99dc-498fe5af2078 Collantes, M. (María)|||/items/102ad3e7-3f57-4958-8e97-39af1c92626b Alegria, E. (Eduardo)|||/items/66783cb2-c3ec-4c12-bed5-74d89aafeef0 Merino, J. (Juana)|||/items/e1c30c26-556a-42b9-adf9-aaae7bb3b425 Peñuelas-Sanchez, I. (Ivan)|||/items/7022e2fa-b3b0-48ed-8d39-2020cfae85a4 Garcia-Verdugo, J.M. (José Manuel)|||/items/06bcbe24-fc30-4c80-9f45-6264207191ba Pelacho-Samper, B. (Beatriz)|||/items/aca35c0e-183d-435d-9d44-1888e0854ff3 Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Bone marrow stem cells Angiogenesis Chronic myocardial infarction Cardiac remodeling Área de Terapia Celular |
| topic |
Bone marrow stem cells Angiogenesis Chronic myocardial infarction Cardiac remodeling Área de Terapia Celular |
| description |
The aim of this study is to assess the long-term effect of mesenchymal stem cells (MSC) transplantation in a rat model of chronic myocardial infarction (MI) in comparison with the effect of bone marrow mononuclear cells (BM-MNC) transplant. Five weeks after induction of MI, rats were allocated to receive intramyocardial injection of 106 GFP-expressing cells (BM-MNC or MSC) or medium as control. Heart function (echocardiography and 18F-FDG-microPET) and histological studies were performed 3 months after transplantation and cell fate was analyzed along the experiment (1 and 2 weeks and 1 and 3 months). The main findings of this study were that both BM-derived populations, BM-MNC and MSC, induced a long-lasting (3 months) improvement in LVEF (BM-MNC: 26.61 ± 2.01% to 46.61 ± 3.7%, p < 0.05; MSC: 27.5 ± 1.28% to 38.8 ± 3.2%, p < 0.05) but remarkably, only MSC improved tissue metabolism quantified by 18FFDG uptake (71.15 ± 1.27 to 76.31 ± 1.11, p < 0.01), which was thereby associated with a smaller infarct size and scar collagen content and also with a higher revascularization degree. Altogether, results show that MSC provides a long-term superior benefit than whole BM-MNC transplantation in a rat model of chronic MI. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009 2009-11-01 2009 2009-11-01 2010 2010-10-19 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/13519 |
| url |
https://hdl.handle.net/10171/13519 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Cognizant Communication Corporation |
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Cognizant Communication Corporation |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869403324657172480 |
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15,300719 |