aSynPEP-DB

Pintado-Grima, Carlos|||0000-0002-8544-959X; Bárcenas, Oriol|||0000-0002-8439-4005; Iglesias, Valentin|||0000-0002-6133-0869; Santos Suárez, Jaime|||0000-0001-9045-7765; Manglano-Artuñedo, Zoe; Pallarès i Goitiz, Irantzu|||0000-0002-8205-2060; Burdukiewicz, Michał|||0000-0001-8926-582X; Ventura, Salvador|||0000-0002-9652-6351

aSynPEP-DB

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, yet effective treatments able to stop or delay disease progression remain elusive. The aggregation of a presynaptic protein, α-synuclein (aSyn), is the primary neurological hallmark of PD and, thus, a promising ta...

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Autores:	Pintado-Grima, Carlos\|\|\|0000-0002-8544-959X, Bárcenas, Oriol\|\|\|0000-0002-8439-4005, Iglesias, Valentin\|\|\|0000-0002-6133-0869, Santos Suárez, Jaime\|\|\|0000-0001-9045-7765, Manglano-Artuñedo, Zoe, Pallarès i Goitiz, Irantzu\|\|\|0000-0002-8205-2060, Burdukiewicz, Michał\|\|\|0000-0001-8926-582X, Ventura, Salvador\|\|\|0000-0002-9652-6351
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:304952
Acceso en línea:	https://ddd.uab.cat/record/304952 https://dx.doi.org/urn:doi:10.1093/database/baad084
Access Level:	acceso abierto

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repository_id_str
spelling	aSynPEP-DBa database of biogenic peptides for inhibiting α-synuclein aggregationPintado-Grima, Carlos\|\|\|0000-0002-8544-959XBárcenas, Oriol\|\|\|0000-0002-8439-4005Iglesias, Valentin\|\|\|0000-0002-6133-0869Santos Suárez, Jaime\|\|\|0000-0001-9045-7765Manglano-Artuñedo, ZoePallarès i Goitiz, Irantzu\|\|\|0000-0002-8205-2060Burdukiewicz, Michał\|\|\|0000-0001-8926-582XVentura, Salvador\|\|\|0000-0002-9652-6351Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, yet effective treatments able to stop or delay disease progression remain elusive. The aggregation of a presynaptic protein, α-synuclein (aSyn), is the primary neurological hallmark of PD and, thus, a promising target for therapeutic intervention. However, the lack of consensus on the molecular properties required to specifically bind the toxic species formed during aSyn aggregation has hindered the development of therapeutic molecules. Recently, we defined and experimentally validated a peptide architecture that demonstrated high affinity and selectivity in binding to aSyn toxic oligomers and fibrils, effectively preventing aSyn pathogenic aggregation. Human peptides with such properties may have neuroprotective activities and hold a huge therapeutic interest. Driven by this idea, here, we developed a discriminative algorithm for the screening of human endogenous neuropeptides, antimicrobial peptides and diet-derived bioactive peptides with the potential to inhibit aSyn aggregation. We identified over 100 unique biogenic peptide candidates and ensembled a comprehensive database (aSynPEP-DB) that collects their physicochemical features, source datasets and additional therapeutic-relevant information, including their sites of expression and associated pathways. Besides, we provide access to the discriminative algorithm to extend its application to the screening of artificial peptides or new peptide datasets. aSynPEP-DB is a unique repository of peptides with the potential to modulate aSyn aggregation, serving as a platform for the identification of previously unexplored therapeutic agents. Database URL:. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/304952https://dx.doi.org/urn:doi:10.1093/database/baad084reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2023FI300018European Commission https://doi.org/10.13039/501100000780 952334Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-105017RB-I00open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3049522026-06-06T12:50:31Z
dc.title.none.fl_str_mv	aSynPEP-DB a database of biogenic peptides for inhibiting α-synuclein aggregation
title	aSynPEP-DB
spellingShingle	aSynPEP-DB Pintado-Grima, Carlos\|\|\|0000-0002-8544-959X
title_short	aSynPEP-DB
title_full	aSynPEP-DB
title_fullStr	aSynPEP-DB
title_full_unstemmed	aSynPEP-DB
title_sort	aSynPEP-DB
dc.creator.none.fl_str_mv	Pintado-Grima, Carlos\|\|\|0000-0002-8544-959X Bárcenas, Oriol\|\|\|0000-0002-8439-4005 Iglesias, Valentin\|\|\|0000-0002-6133-0869 Santos Suárez, Jaime\|\|\|0000-0001-9045-7765 Manglano-Artuñedo, Zoe Pallarès i Goitiz, Irantzu\|\|\|0000-0002-8205-2060 Burdukiewicz, Michał\|\|\|0000-0001-8926-582X Ventura, Salvador\|\|\|0000-0002-9652-6351
author	Pintado-Grima, Carlos\|\|\|0000-0002-8544-959X
author_facet	Pintado-Grima, Carlos\|\|\|0000-0002-8544-959X Bárcenas, Oriol\|\|\|0000-0002-8439-4005 Iglesias, Valentin\|\|\|0000-0002-6133-0869 Santos Suárez, Jaime\|\|\|0000-0001-9045-7765 Manglano-Artuñedo, Zoe Pallarès i Goitiz, Irantzu\|\|\|0000-0002-8205-2060 Burdukiewicz, Michał\|\|\|0000-0001-8926-582X Ventura, Salvador\|\|\|0000-0002-9652-6351
author_role	author
author2	Bárcenas, Oriol\|\|\|0000-0002-8439-4005 Iglesias, Valentin\|\|\|0000-0002-6133-0869 Santos Suárez, Jaime\|\|\|0000-0001-9045-7765 Manglano-Artuñedo, Zoe Pallarès i Goitiz, Irantzu\|\|\|0000-0002-8205-2060 Burdukiewicz, Michał\|\|\|0000-0001-8926-582X Ventura, Salvador\|\|\|0000-0002-9652-6351
author2_role	author author author author author author author
description	Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, yet effective treatments able to stop or delay disease progression remain elusive. The aggregation of a presynaptic protein, α-synuclein (aSyn), is the primary neurological hallmark of PD and, thus, a promising target for therapeutic intervention. However, the lack of consensus on the molecular properties required to specifically bind the toxic species formed during aSyn aggregation has hindered the development of therapeutic molecules. Recently, we defined and experimentally validated a peptide architecture that demonstrated high affinity and selectivity in binding to aSyn toxic oligomers and fibrils, effectively preventing aSyn pathogenic aggregation. Human peptides with such properties may have neuroprotective activities and hold a huge therapeutic interest. Driven by this idea, here, we developed a discriminative algorithm for the screening of human endogenous neuropeptides, antimicrobial peptides and diet-derived bioactive peptides with the potential to inhibit aSyn aggregation. We identified over 100 unique biogenic peptide candidates and ensembled a comprehensive database (aSynPEP-DB) that collects their physicochemical features, source datasets and additional therapeutic-relevant information, including their sites of expression and associated pathways. Besides, we provide access to the discriminative algorithm to extend its application to the screening of artificial peptides or new peptide datasets. aSynPEP-DB is a unique repository of peptides with the potential to modulate aSyn aggregation, serving as a platform for the identification of previously unexplored therapeutic agents. Database URL:.
publishDate	2023
dc.date.none.fl_str_mv	2 2023-01-01 2023 2023-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/304952 https://dx.doi.org/urn:doi:10.1093/database/baad084
url	https://ddd.uab.cat/record/304952 https://dx.doi.org/urn:doi:10.1093/database/baad084
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2023FI300018 European Commission https://doi.org/10.13039/501100000780 952334 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-105017RB-I00
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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aSynPEP-DB

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