Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse

[EN]Postnatally, the Purkinje cell degen-eration mutant mice lose the main projecting neurons ofthe main olfactory bulb (OB): mitral cells (MC). Inadult animals, progenitor cells from the rostral migra-tory stream (RMS) differentiate into bulbar interneur-ons that modulate MC activity. In the presen...

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Authors: Valero , Jorge, Weruaga Prieto, Eduardo, Murias, A.R., Recio, J.S., Curto, G. G., Gómez Rodríguez, Carmela, Alonso Peña, José Ramón
Format: article
Status:Published version
Publication Date:2007
Country:España
Institution:Universidad de Salamanca (USAL)
Repository:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/169645
Online Access:http://hdl.handle.net/10366/169645
Access Level:Embargoed access
Keyword:BrdU
Neurogenesis
Neuronal degeneration
Reelin
Rostral Migratory Stream
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spelling Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouseValero , JorgeWeruaga Prieto, EduardoMurias, A.R.Recio, J.S.Curto, G. G.Gómez Rodríguez, CarmelaAlonso Peña, José RamónBrdUNeurogenesisNeuronal degenerationReelinRostral Migratory Stream[EN]Postnatally, the Purkinje cell degen-eration mutant mice lose the main projecting neurons ofthe main olfactory bulb (OB): mitral cells (MC). Inadult animals, progenitor cells from the rostral migra-tory stream (RMS) differentiate into bulbar interneur-ons that modulate MC activity. In the present work, westudied changes in proliferation, tangential migration,radial migration patterns, and the survival of thesenewly generated neurons in this neurodegeneration ani-mal model. The animals were injected with bromodeoxy-uridine 2 weeks or 2 months before killing in order tolabel neuroblast incorporation into the OB and to ana-lyze the survival of these cells after differentiation,respectively. Both the organization and cellular compo-sition of the RMS and the differentiation of the newly generated neurons in the OB were studied using specificmarkers of glial cells, neuroblasts, and mature neurons.No changes were observed in the cell proliferation ratenor in their tangential migration through the RMS, indi-cating that migrating neuroblasts are only weakly re-sponsive to the alteration in their target region, the OB.However, the absence of MC does elicit differences inthe final destination of the newly generated interneur-ons. Moreover, the loss of MC also produces changes inthe survival of the newly generated interneurons, in ac-cordance with the dramatic decrease in the number ofsynaptic targets availableWileyinfo202620262007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/169645reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésDGI (Ministerio de Ciencia y Tecnología); contract grant number: BFI 2003-03719Junta de Castilla y LeónAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:gredos.usal.es:10366/1696452026-06-07T06:28:51Z
dc.title.none.fl_str_mv Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse
title Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse
spellingShingle Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse
Valero , Jorge
BrdU
Neurogenesis
Neuronal degeneration
Reelin
Rostral Migratory Stream
title_short Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse
title_full Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse
title_fullStr Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse
title_full_unstemmed Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse
title_sort Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse
dc.creator.none.fl_str_mv Valero , Jorge
Weruaga Prieto, Eduardo
Murias, A.R.
Recio, J.S.
Curto, G. G.
Gómez Rodríguez, Carmela
Alonso Peña, José Ramón
author Valero , Jorge
author_facet Valero , Jorge
Weruaga Prieto, Eduardo
Murias, A.R.
Recio, J.S.
Curto, G. G.
Gómez Rodríguez, Carmela
Alonso Peña, José Ramón
author_role author
author2 Weruaga Prieto, Eduardo
Murias, A.R.
Recio, J.S.
Curto, G. G.
Gómez Rodríguez, Carmela
Alonso Peña, José Ramón
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BrdU
Neurogenesis
Neuronal degeneration
Reelin
Rostral Migratory Stream
topic BrdU
Neurogenesis
Neuronal degeneration
Reelin
Rostral Migratory Stream
description [EN]Postnatally, the Purkinje cell degen-eration mutant mice lose the main projecting neurons ofthe main olfactory bulb (OB): mitral cells (MC). Inadult animals, progenitor cells from the rostral migra-tory stream (RMS) differentiate into bulbar interneur-ons that modulate MC activity. In the present work, westudied changes in proliferation, tangential migration,radial migration patterns, and the survival of thesenewly generated neurons in this neurodegeneration ani-mal model. The animals were injected with bromodeoxy-uridine 2 weeks or 2 months before killing in order tolabel neuroblast incorporation into the OB and to ana-lyze the survival of these cells after differentiation,respectively. Both the organization and cellular compo-sition of the RMS and the differentiation of the newly generated neurons in the OB were studied using specificmarkers of glial cells, neuroblasts, and mature neurons.No changes were observed in the cell proliferation ratenor in their tangential migration through the RMS, indi-cating that migrating neuroblasts are only weakly re-sponsive to the alteration in their target region, the OB.However, the absence of MC does elicit differences inthe final destination of the newly generated interneur-ons. Moreover, the loss of MC also produces changes inthe survival of the newly generated interneurons, in ac-cordance with the dramatic decrease in the number ofsynaptic targets available
publishDate 2007
dc.date.none.fl_str_mv 2007
2026
2026
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/169645
url http://hdl.handle.net/10366/169645
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv DGI (Ministerio de Ciencia y Tecnología); contract grant number: BFI 2003-03719
Junta de Castilla y León
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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