Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak

8 páginas, 2 figuras, 1 tabla.

Detalles Bibliográficos
Autores: Pérez-Lago, Laura, Martínez Lozano, Helena, Pajares Díaz, José Antonio, Díaz Gómez, Arantxa, Machado, Marina, Sola-Campoy, Pedro J., Herranz, Marta, Valerio, Maricela, Quesada Cubo, Víctor, Gómez Ruiz, Maria del Mar, López Fresneña, Nieves, Sánchez Arcilla, Ignacio, Comas, Iñaki, González-Candelas, Fernando, García San José, Sonia, Bañares, Rafael, Catalán, Pilar, Muñoz, Patricia, García de Viedma, Darío
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/249202
Acceso en línea:http://hdl.handle.net/10261/249202
Access Level:acceso abierto
Palabra clave:COVID-19
SARS-CoV-2
Nosocomial transmission
Genomic epidemiology
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spelling Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex OutbreakPérez-Lago, LauraMartínez Lozano, HelenaPajares Díaz, José AntonioDíaz Gómez, ArantxaMachado, MarinaSola-Campoy, Pedro J.Herranz, MartaValerio, MaricelaQuesada Cubo, VíctorGómez Ruiz, Maria del MarLópez Fresneña, NievesSánchez Arcilla, IgnacioComas, IñakiGonzález-Candelas, FernandoGarcía San José, SoniaBañares, RafaelCatalán, PilarMuñoz, PatriciaGarcía de Viedma, DaríoCOVID-19SARS-CoV-2Nosocomial transmissionGenomic epidemiology8 páginas, 2 figuras, 1 tabla.SARS-CoV-2 nosocomial outbreaks in the first COVID-19 wave were likely associated with a shortage of personal protective equipment and scarce indications on control measures. Having covered these limitations, updates on current SARS-CoV-2 nosocomial outbreaks are required. We carried out an in-depth analysis of a 27-day nosocomial outbreak in a gastroenterology ward in our hospital, potentially involving 15 patients and 3 health care workers. Patients had stayed in one of three neighboring rooms in the ward. The severity of the infections in six of the cases and a high fatality rate made the clinicians suspect the possible involvement of a single virulent strain persisting in those rooms. Whole-genome sequencing (WGS) of the strains from 12 patients and 1 health care worker revealed an unexpected complexity. Five different SARS-CoV-2 strains were identified, two infecting a single patient each, ruling out their relationship with the outbreak; the remaining three strains were involved in three independent, overlapping, limited transmission clusters with three, three, and five cases. Whole-genome sequencing was key to understand the complexity of this outbreak. IMPORTANCE We report a complex epidemiological scenario of a nosocomial COVID-19 outbreak in the second wave, based on WGS analysis. Initially, standard epidemiological findings led to the assumption of a homogeneous outbreak caused by a single SARS-CoV-2 strain. The discriminatory power of WGS offered a strikingly different perspective consisting of five introductions of different strains, with only half of them causing secondary cases in three independent overlapping clusters. Our study exemplifies how complex the SARS-CoV-2 transmission in the nosocomial setting during the second COVID-19 wave occurred and leads to extending the analysis of outbreaks beyond the initial epidemiological assumptions.This work was supported by Instituto de Salud Carlos III (Ref COV20/00140: SeqCOVIDConsorcio para la epidemiología genómica de SARS-CoV-2 en España) and by Consejo Superior de Investigaciones Científicas (CSIC) (PTI Salud Global). L.P.-L. holds Miguel Servet contracts CP15/00075 and CPII20/00001.Peer reviewedAmerican Society for MicrobiologyInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas (España)Comas, Iñaki [0000-0001-5504-9408]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/249202reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésPérez-Lago, Laura; Martínez Lozano, Helena; Pajares Díaz, José Antonio; Díaz Gómez, Arantxa; Machado, Marina; Sola-Campoy, Pedro J.; Herranz, Marta; Valerio, Maricela; Quesada Cubo, Víctor; Gómez Ruiz, Maria del Mar; López Fresneña, Nieves; Sánchez Arcilla, Ignacio; Comas, Iñaki; González-Candelas, Fernando; García San José, Sonia; Bañares, Rafael; Catalán, Pilar; Muñoz, Patricia; García de Viedma, Darío; 2021; Overlapping of independent SARS-CoV-2 nosocomial transmissions in a complex outbreak [Preprint]; Research Square; https://doi.org/10.21203/rs.3.rs-305824/v1https://dx.doi.org/10.1128/mSphere.00389-21Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2492022026-05-22T06:33:51Z
dc.title.none.fl_str_mv Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak
title Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak
spellingShingle Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak
Pérez-Lago, Laura
COVID-19
SARS-CoV-2
Nosocomial transmission
Genomic epidemiology
title_short Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak
title_full Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak
title_fullStr Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak
title_full_unstemmed Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak
title_sort Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak
dc.creator.none.fl_str_mv Pérez-Lago, Laura
Martínez Lozano, Helena
Pajares Díaz, José Antonio
Díaz Gómez, Arantxa
Machado, Marina
Sola-Campoy, Pedro J.
Herranz, Marta
Valerio, Maricela
Quesada Cubo, Víctor
Gómez Ruiz, Maria del Mar
López Fresneña, Nieves
Sánchez Arcilla, Ignacio
Comas, Iñaki
González-Candelas, Fernando
García San José, Sonia
Bañares, Rafael
Catalán, Pilar
Muñoz, Patricia
García de Viedma, Darío
author Pérez-Lago, Laura
author_facet Pérez-Lago, Laura
Martínez Lozano, Helena
Pajares Díaz, José Antonio
Díaz Gómez, Arantxa
Machado, Marina
Sola-Campoy, Pedro J.
Herranz, Marta
Valerio, Maricela
Quesada Cubo, Víctor
Gómez Ruiz, Maria del Mar
López Fresneña, Nieves
Sánchez Arcilla, Ignacio
Comas, Iñaki
González-Candelas, Fernando
García San José, Sonia
Bañares, Rafael
Catalán, Pilar
Muñoz, Patricia
García de Viedma, Darío
author_role author
author2 Martínez Lozano, Helena
Pajares Díaz, José Antonio
Díaz Gómez, Arantxa
Machado, Marina
Sola-Campoy, Pedro J.
Herranz, Marta
Valerio, Maricela
Quesada Cubo, Víctor
Gómez Ruiz, Maria del Mar
López Fresneña, Nieves
Sánchez Arcilla, Ignacio
Comas, Iñaki
González-Candelas, Fernando
García San José, Sonia
Bañares, Rafael
Catalán, Pilar
Muñoz, Patricia
García de Viedma, Darío
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas (España)
Comas, Iñaki [0000-0001-5504-9408]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv COVID-19
SARS-CoV-2
Nosocomial transmission
Genomic epidemiology
topic COVID-19
SARS-CoV-2
Nosocomial transmission
Genomic epidemiology
description 8 páginas, 2 figuras, 1 tabla.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/249202
url http://hdl.handle.net/10261/249202
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Pérez-Lago, Laura; Martínez Lozano, Helena; Pajares Díaz, José Antonio; Díaz Gómez, Arantxa; Machado, Marina; Sola-Campoy, Pedro J.; Herranz, Marta; Valerio, Maricela; Quesada Cubo, Víctor; Gómez Ruiz, Maria del Mar; López Fresneña, Nieves; Sánchez Arcilla, Ignacio; Comas, Iñaki; González-Candelas, Fernando; García San José, Sonia; Bañares, Rafael; Catalán, Pilar; Muñoz, Patricia; García de Viedma, Darío; 2021; Overlapping of independent SARS-CoV-2 nosocomial transmissions in a complex outbreak [Preprint]; Research Square; https://doi.org/10.21203/rs.3.rs-305824/v1
https://dx.doi.org/10.1128/mSphere.00389-21
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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