Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination

Background: In Spain, the influenza vaccine effectiveness (VE) was estimated in the last three seasons using the observational study cycEVA conducted in the frame of the existing Spanish Influenza Sentinel Surveillance System. The objective of the study was to estimate influenza vaccine effectivenes...

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Autores: Jiménez Jorge, Silvia, Mateo, Salvador de, Delgado-Sanz, Concha, Pozo Rodríguez, Francisco, Casas, Inmaculada|||0000-0003-1840-1198, García Cenoz, Manuel|||0000-0001-7316-9104, Castilla, Jesus|||0000-0002-6396-7265, Pérez, Esteban, Gallardo-García, Virtudes, Rodriguez, Carolina, Vega, Tomás, Quiñones, Carmen, Martínez, Eva, Vanrell, Juana María, Giménez, Jaume, Castrillejo, Daniel, Serrano, María del Carmen, Mauro Ramos, Julián, Larrauri, Amparo|||0000-0002-1704-2245
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:112680
Acceso en línea:https://ddd.uab.cat/record/112680
https://dx.doi.org/urn:doi:10.1186/1471-2334-13-441
Access Level:acceso abierto
Palabra clave:Influenza
Vaccine effectiveness
Case-control studies
Sentinel networks
Discordant strain
Waning immunity
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spelling Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccinationJiménez Jorge, SilviaMateo, Salvador deDelgado-Sanz, ConchaPozo Rodríguez, FranciscoCasas, Inmaculada|||0000-0003-1840-1198García Cenoz, Manuel|||0000-0001-7316-9104Castilla, Jesus|||0000-0002-6396-7265Pérez, EstebanGallardo-García, VirtudesRodriguez, CarolinaVega, TomásQuiñones, CarmenMartínez, EvaVanrell, Juana MaríaGiménez, JaumeCastrillejo, DanielSerrano, María del CarmenMauro Ramos, JuliánLarrauri, Amparo|||0000-0002-1704-2245InfluenzaVaccine effectivenessCase-control studiesSentinel networksDiscordant strainWaning immunityBackground: In Spain, the influenza vaccine effectiveness (VE) was estimated in the last three seasons using the observational study cycEVA conducted in the frame of the existing Spanish Influenza Sentinel Surveillance System. The objective of the study was to estimate influenza vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza-like illness (ILI) among the target groups for vaccination in Spain in the 2011-2012 season. We also studied influenza VE in the early (weeks 52/2011-7/2012) and late (weeks 8-14/2012) phases of the epidemic and according to time since vaccination. Methods: Medically attended patients with ILI were systematically swabbed to collect information on exposure, laboratory outcome and confounding factors. Patients belonging to target groups for vaccination and who were swabbed <8 days after symptom onset were included. Cases tested positive for influenza and controls tested negative for any influenza virus. To examine the effect of a late season, analyses were performed according to the phase of the season and according to the time between vaccination and symptoms onset. Results: The overall adjusted influenza VE against A(H3N2) was 45% (95% CI, 0-69). The estimated influenza VE was 52% (95% CI, -3 to 78), 40% (95% CI, -40 to 74) and 22% (95% CI, -135 to 74) at 3.5 months, 3.5-4 months, and. 22013-01-0120132013-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/112680https://dx.doi.org/urn:doi:10.1186/1471-2334-13-441reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/2.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1126802026-06-06T12:50:31Z
dc.title.none.fl_str_mv Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination
title Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination
spellingShingle Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination
Jiménez Jorge, Silvia
Influenza
Vaccine effectiveness
Case-control studies
Sentinel networks
Discordant strain
Waning immunity
title_short Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination
title_full Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination
title_fullStr Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination
title_full_unstemmed Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination
title_sort Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination
dc.creator.none.fl_str_mv Jiménez Jorge, Silvia
Mateo, Salvador de
Delgado-Sanz, Concha
Pozo Rodríguez, Francisco
Casas, Inmaculada|||0000-0003-1840-1198
García Cenoz, Manuel|||0000-0001-7316-9104
Castilla, Jesus|||0000-0002-6396-7265
Pérez, Esteban
Gallardo-García, Virtudes
Rodriguez, Carolina
Vega, Tomás
Quiñones, Carmen
Martínez, Eva
Vanrell, Juana María
Giménez, Jaume
Castrillejo, Daniel
Serrano, María del Carmen
Mauro Ramos, Julián
Larrauri, Amparo|||0000-0002-1704-2245
author Jiménez Jorge, Silvia
author_facet Jiménez Jorge, Silvia
Mateo, Salvador de
Delgado-Sanz, Concha
Pozo Rodríguez, Francisco
Casas, Inmaculada|||0000-0003-1840-1198
García Cenoz, Manuel|||0000-0001-7316-9104
Castilla, Jesus|||0000-0002-6396-7265
Pérez, Esteban
Gallardo-García, Virtudes
Rodriguez, Carolina
Vega, Tomás
Quiñones, Carmen
Martínez, Eva
Vanrell, Juana María
Giménez, Jaume
Castrillejo, Daniel
Serrano, María del Carmen
Mauro Ramos, Julián
Larrauri, Amparo|||0000-0002-1704-2245
author_role author
author2 Mateo, Salvador de
Delgado-Sanz, Concha
Pozo Rodríguez, Francisco
Casas, Inmaculada|||0000-0003-1840-1198
García Cenoz, Manuel|||0000-0001-7316-9104
Castilla, Jesus|||0000-0002-6396-7265
Pérez, Esteban
Gallardo-García, Virtudes
Rodriguez, Carolina
Vega, Tomás
Quiñones, Carmen
Martínez, Eva
Vanrell, Juana María
Giménez, Jaume
Castrillejo, Daniel
Serrano, María del Carmen
Mauro Ramos, Julián
Larrauri, Amparo|||0000-0002-1704-2245
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Influenza
Vaccine effectiveness
Case-control studies
Sentinel networks
Discordant strain
Waning immunity
topic Influenza
Vaccine effectiveness
Case-control studies
Sentinel networks
Discordant strain
Waning immunity
description Background: In Spain, the influenza vaccine effectiveness (VE) was estimated in the last three seasons using the observational study cycEVA conducted in the frame of the existing Spanish Influenza Sentinel Surveillance System. The objective of the study was to estimate influenza vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza-like illness (ILI) among the target groups for vaccination in Spain in the 2011-2012 season. We also studied influenza VE in the early (weeks 52/2011-7/2012) and late (weeks 8-14/2012) phases of the epidemic and according to time since vaccination. Methods: Medically attended patients with ILI were systematically swabbed to collect information on exposure, laboratory outcome and confounding factors. Patients belonging to target groups for vaccination and who were swabbed <8 days after symptom onset were included. Cases tested positive for influenza and controls tested negative for any influenza virus. To examine the effect of a late season, analyses were performed according to the phase of the season and according to the time between vaccination and symptoms onset. Results: The overall adjusted influenza VE against A(H3N2) was 45% (95% CI, 0-69). The estimated influenza VE was 52% (95% CI, -3 to 78), 40% (95% CI, -40 to 74) and 22% (95% CI, -135 to 74) at 3.5 months, 3.5-4 months, and.
publishDate 2013
dc.date.none.fl_str_mv 2
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/112680
https://dx.doi.org/urn:doi:10.1186/1471-2334-13-441
url https://ddd.uab.cat/record/112680
https://dx.doi.org/urn:doi:10.1186/1471-2334-13-441
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/2.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/2.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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