Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen

[EN]The effect of the polyvinylpyrrolidone and/or hydroxypropyl-b-cyclodextrin on the photolability of aqueous solutions of the antiinflammatory drug Naproxen was studied. Kinetic studies revealed that the presence of all of these additives reduced drug photodegradation. In all cases, the presence o...

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Detalles Bibliográficos
Autores: Valero Juan, Margarita, Esteban, Brígida
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2004
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:dnet:gredos______::c4c7d3459b132ce67757573104b9dd16
Acceso en línea:http://hdl.handle.net/10366/171081
Access Level:acceso abierto
Palabra clave:Naproxen photodegradation
Hydroxypropyl-b-cyclodextrin
Polyvinyl pyrrolidone
Binary complex
Ternary complex
Photosensitizing effects
Naproxen
Ternary Complex Factors
Photosensitizing Agents
fármacos fotosensibilizantes
naproxeno
factores complejos ternarios
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repository_id_str
spelling Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of NaproxenValero Juan, MargaritaEsteban, BrígidaNaproxen photodegradationHydroxypropyl-b-cyclodextrinPolyvinyl pyrrolidoneBinary complexTernary complexPhotosensitizing effectsNaproxenTernary Complex FactorsPhotosensitizing Agentsfármacos fotosensibilizantesnaproxenofactores complejos ternarios[EN]The effect of the polyvinylpyrrolidone and/or hydroxypropyl-b-cyclodextrin on the photolability of aqueous solutions of the antiinflammatory drug Naproxen was studied. Kinetic studies revealed that the presence of all of these additives reduced drug photodegradation. In all cases, the presence of the different additives elicited a change in the photomixture composition, being the alcoholic derivative the major photoproduct formed. Nevertheless, the change in the efficiency of the process and the amount of the photoproducts formed in the different systems were not related with the biodamage produced by the drug. In this sense, the presence of free Naproxen clearly sensitized the photoperoxidation of linoleic acid. The photosensitizing effect decreased as the PVP concentration increased. Different protection provides the binary (Naproxen:HP-b-CD) and ternary (Naproxen:HP-b- CD:PVP) complexes. The binary complex formation had not effect on the prevention of photooxidation of linoleic acid sensitized by the drug, whereas the ternary complex formation supresses the drug effect. The different behaviour observed with b-CD and HPb- CD and the structural differences of both cyclodextrins seem to indicate that in the case of the HP-b-CD the linoleic binds with the CD and takes contact with the drug. These results confirm that in these systems the prevention of biodamage would be due to a decrease in the contact between the short-lived species generated during Naproxen photodegradation and biological structures, rather than due to the nature or amount of the photoproducts. In addition, the ability of the complex to interact with the biological structure depends on the structure of both interacting species.Elsevier202620262004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10366/171081reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:gredos______::c4c7d3459b132ce67757573104b9dd162026-06-07T06:28:51Z
dc.title.none.fl_str_mv Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen
title Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen
spellingShingle Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen
Valero Juan, Margarita
Naproxen photodegradation
Hydroxypropyl-b-cyclodextrin
Polyvinyl pyrrolidone
Binary complex
Ternary complex
Photosensitizing effects
Naproxen
Ternary Complex Factors
Photosensitizing Agents
fármacos fotosensibilizantes
naproxeno
factores complejos ternarios
title_short Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen
title_full Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen
title_fullStr Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen
title_full_unstemmed Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen
title_sort Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-β-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen
dc.creator.none.fl_str_mv Valero Juan, Margarita
Esteban, Brígida
author Valero Juan, Margarita
author_facet Valero Juan, Margarita
Esteban, Brígida
author_role author
author2 Esteban, Brígida
author2_role author
dc.subject.none.fl_str_mv Naproxen photodegradation
Hydroxypropyl-b-cyclodextrin
Polyvinyl pyrrolidone
Binary complex
Ternary complex
Photosensitizing effects
Naproxen
Ternary Complex Factors
Photosensitizing Agents
fármacos fotosensibilizantes
naproxeno
factores complejos ternarios
topic Naproxen photodegradation
Hydroxypropyl-b-cyclodextrin
Polyvinyl pyrrolidone
Binary complex
Ternary complex
Photosensitizing effects
Naproxen
Ternary Complex Factors
Photosensitizing Agents
fármacos fotosensibilizantes
naproxeno
factores complejos ternarios
description [EN]The effect of the polyvinylpyrrolidone and/or hydroxypropyl-b-cyclodextrin on the photolability of aqueous solutions of the antiinflammatory drug Naproxen was studied. Kinetic studies revealed that the presence of all of these additives reduced drug photodegradation. In all cases, the presence of the different additives elicited a change in the photomixture composition, being the alcoholic derivative the major photoproduct formed. Nevertheless, the change in the efficiency of the process and the amount of the photoproducts formed in the different systems were not related with the biodamage produced by the drug. In this sense, the presence of free Naproxen clearly sensitized the photoperoxidation of linoleic acid. The photosensitizing effect decreased as the PVP concentration increased. Different protection provides the binary (Naproxen:HP-b-CD) and ternary (Naproxen:HP-b- CD:PVP) complexes. The binary complex formation had not effect on the prevention of photooxidation of linoleic acid sensitized by the drug, whereas the ternary complex formation supresses the drug effect. The different behaviour observed with b-CD and HPb- CD and the structural differences of both cyclodextrins seem to indicate that in the case of the HP-b-CD the linoleic binds with the CD and takes contact with the drug. These results confirm that in these systems the prevention of biodamage would be due to a decrease in the contact between the short-lived species generated during Naproxen photodegradation and biological structures, rather than due to the nature or amount of the photoproducts. In addition, the ability of the complex to interact with the biological structure depends on the structure of both interacting species.
publishDate 2004
dc.date.none.fl_str_mv 2004
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/171081
url http://hdl.handle.net/10366/171081
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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