Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration

This article belongs to the Special Issue Polymeric Materials for Dental Applications.

Detalles Bibliográficos
Autores: Toledano-Osorio, Manuel, Asady, Samara, García-Godoy, Franklin, Serrera-Figallo, María-Ángeles, Benítez-García, José A., Osorio, Raquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/236990
Acceso en línea:http://hdl.handle.net/10261/236990
Access Level:acceso abierto
Palabra clave:Collagen
Membrane
Biodegradation
Bone regeneration
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spelling Differential Biodegradation Kinetics of Collagen Membranes for Bone RegenerationToledano-Osorio, ManuelAsady, SamaraToledano-Osorio, ManuelGarcía-Godoy, FranklinSerrera-Figallo, María-ÁngelesBenítez-García, José A.Osorio, RaquelCollagenMembraneBiodegradationBone regenerationThis article belongs to the Special Issue Polymeric Materials for Dental Applications.Native collagen-based membranes are used to guide bone regeneration; but due to their rapid biodegradation, this treatment is often unpredictable. The purpose of this study was to investigate the biodegradability of natural collagen membranes. Three non-cross-linked resorbable collagen barrier membranes were tested: Derma Fina (porcine dermis), Evolution Standard (equine pericardium) and Duo-Teck (equine lyophilized collagen felt). 10 × 10 mm2 pieces of membranes were submitted to three different degradation procedures: (1) hydrolytic degradation in phosphate buffer solution, (2) enzyme resistance, using a 0.25% porcine trypsin solution, and (3) bacterial (Clostridium histolyticum) collagenase resistance test. Weight measurements were performed with an analytic microbalance. Thickness was measured with a digital caliper. Membranes were analyzed at different time-points, up to 21 d of immersion. A stereomicroscope was used to obtain membranes’ images. ANOVA and Student Newman Keuls were used for mean comparisons (p < 0.05), except when analyzing differences between time-points within the same membrane and solution where pair-wise comparisons were applied (p < 0.001). Derma Fina attained the highest resistance to all degradation challenges. Duo-Teck was the most susceptible membrane to degradation, complete degradation occurred as soon as 8 h. The bacterial collagenase solution performed as the most aggressive test as all membranes presented 100% degradation before 21 d.This work was funded by the Ministry of Economy and Competitiveness and European Regional Development Fund (MINECO/FEDER MAT2017-85999P) and Regional Government of Andalusia Research Fund (A-BIO-157-UGR-18) from Spain.Multidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/236990reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-85999-Phttp://doi.org/10.3390/polym12061290Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2369902026-05-22T06:33:51Z
dc.title.none.fl_str_mv Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
title Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
spellingShingle Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
Toledano-Osorio, Manuel
Collagen
Membrane
Biodegradation
Bone regeneration
title_short Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
title_full Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
title_fullStr Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
title_full_unstemmed Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
title_sort Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
dc.creator.none.fl_str_mv Toledano-Osorio, Manuel
Asady, Samara
Toledano-Osorio, Manuel
García-Godoy, Franklin
Serrera-Figallo, María-Ángeles
Benítez-García, José A.
Osorio, Raquel
author Toledano-Osorio, Manuel
author_facet Toledano-Osorio, Manuel
Asady, Samara
García-Godoy, Franklin
Serrera-Figallo, María-Ángeles
Benítez-García, José A.
Osorio, Raquel
author_role author
author2 Asady, Samara
García-Godoy, Franklin
Serrera-Figallo, María-Ángeles
Benítez-García, José A.
Osorio, Raquel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Collagen
Membrane
Biodegradation
Bone regeneration
topic Collagen
Membrane
Biodegradation
Bone regeneration
description This article belongs to the Special Issue Polymeric Materials for Dental Applications.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/236990
url http://hdl.handle.net/10261/236990
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-85999-P
http://doi.org/10.3390/polym12061290
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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