Biodegradable and reinforced membranes based on polycaprolactone and collagen for guided bone regeneration
Meshes or reinforcement for membranes for guided bone regeneration (GBR) are currently made of titanium with high specific mechanical strength, but it is not resorbable and second surgeries are needed. In this project, it was hypothesized that titanium can be replaced by polycaprolactone (PCL), a lo...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/420838 |
| Acesso em linha: | https://hdl.handle.net/2117/420838 https://dx.doi.org/10.1016/j.mtcomm.2024.111039 |
| Access Level: | acceso embargado |
| Palavra-chave: | Guided bone regeneration Bone PCL Mesh Membrane FEM Collagen Àrees temàtiques de la UPC::Enginyeria dels materials |
| Resumo: | Meshes or reinforcement for membranes for guided bone regeneration (GBR) are currently made of titanium with high specific mechanical strength, but it is not resorbable and second surgeries are needed. In this project, it was hypothesized that titanium can be replaced by polycaprolactone (PCL), a long-term biodegradable polymer, while applying a collagen coating to provide a cell barrier effect required in GBR. Different meshes with different patterns were designed and manufactured using 3D printing. Mechanical tests of the meshes were also performed to assess pattern influence on the mechanical properties and, later, a finite element model (FEM) was set to further understand the mechanical behavior of these meshes. In order to obtain the cell barrier effect, meshes were coated with collagen previously treated with NaOH solution using different molarities (1 and 5¿M), assuring a uniform and adhesive collagen coating. The results showed that the patterns influenced the mechanical properties, and the model was validated with the experimental data. Contact angle and SEM analysis confirmed the extension of the alkaline treatment to enhance PCL meshes wettability, needed for the collagen coating. Meshes treated with 5¿M NaOH for 24¿hours at 37°C or room temperature achieved an adequate collagen adhesion that did not exhibit any toxic effect and was able to provide a fibroblast barrier up to 7 days. Finally, it was confirmed that thanks to the application of heat, the meshes can be shaped as required |
|---|