DisProt

The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improv...

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Authors: Hatos, András|||0000-0001-9224-9820, Hajdu-Soltész, Borbála, Monzon, Alexander M., Palopoli, Nicolas, Álvarez, Lucía, Aykac-Fas, Burcu|||0000-0003-3842-731X, Bassot, Claudio|||0000-0001-7161-9028, Benítez, Guillermo I., Bevilacqua, Martina|||0000-0001-7619-871X, Chasapi, Anastasia|||0000-0003-1986-5007, Chemes, Lucía Beatriz|||0000-0003-0192-9906, Davey, Norman E.|||0000-0001-6988-4850, Davidović, Radoslav|||0000-0002-6097-6203, Dunker, A. Keith, Elofsson, Arne|||0000-0002-7115-9751, Gobeill, Julien, Foutel, Nicolás S. G., Sudha, Govindarajan, Guharoy, Mainak, Horvath, Tamas, Iglesias, Valentin|||0000-0002-6133-0869, Kajava, Andrey V., Kovacs, Orsolya P., Lamb, John, Lambrughi, Matteo|||0000-0002-0894-8627, Lazar, Tamas|||0000-0001-7496-6711, Leclercq, Jeremy Y., Leonardi, Emanuela|||0000-0001-8486-8461, Macedo-Ribeiro, Sandra|||0000-0002-7698-1170, Macossay-Castillo, Mauricio, Maiani, Emiliano|||0000-0003-1432-5394, Manso, José A., Marino-Buslje, Cristina|||0000-0002-6564-1920, Martínez-Pérez, Elisabeth, Mészáros, Bálint|||0000-0003-0919-4449, Mičetić, Ivan|||0000-0003-1691-8425, Minervini, Giovanni|||0000-0001-7013-5785, Murvai, Nikoletta, Necci, Marco|||0000-0001-9377-482X, Ouzounis, Christos|||0000-0002-0086-8657, Pajkos, Mátyás|||0000-0001-5791-9825, Paladin, Lisanna, Pancsa, Rita|||0000-0003-0849-9312, Papaleo, Elena|||0000-0002-7376-5894, Parisi, Gustavo|||0000-0001-7444-1624, Pasche, Emilie, Barbosa Pereira, Pedro José, Promponas, Vasilis J.|||0000-0003-3352-4831, Pujols Pujol, Jordi|||0000-0001-9424-5866, Quaglia, Federica|||0000-0002-0341-4888, Ruch, Patrick, Salvatore, Marco, Schad, Eva|||0000-0002-3006-2910, Szabo, Beata, Szaniszló, Tamás|||0000-0002-3130-9284, Tamana, Stella, Tantos, Agnes, Veljkovic, Nevena|||0000-0001-6562-5800, Ventura, Salvador|||0000-0002-9652-6351, Vranken, Wim|||0000-0001-7470-4324, Dosztányi, Zsuzsanna|||0000-0002-3624-5937, Tompa, Peter|||0000-0001-8042-9939, Tosatto, Silvio|||0000-0003-4525-7793, Piovesan, Damiano|||0000-0001-8210-2390
Format: article
Publication Date:2020
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:225226
Online Access:https://ddd.uab.cat/record/225226
https://dx.doi.org/urn:doi:10.1093/nar/gkz975
Access Level:Open access
Keyword:Biological ontologies
Data curation
Databases, Protein
Intrinsically disordered proteins
Molecular sequence annotation
Description
Summary:The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome.

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