Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology has transformed oncology research in many ways. Breast cancer is the most prevalent malignancy globally and triple negative breast cancer (TNBC) is one of the most aggressive subtypes with numerous challenges still to be f...

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Autores: Pont, Mariona, Marqués, Marta, Sorolla Bardají, Maria Alba, Parisi, Eva, Urdanibia, Izaskun, Morales, Serafín, Salud Salvia, Maria Antonieta, Sorolla Bardají, Anabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/464128
Acceso en línea:https://doi.org/10.3390/cancers15174364
https://hdl.handle.net/10459.1/464128
Access Level:acceso abierto
Palabra clave:Breast cancer
Triple negative breast cancer
CRISPR
Applications
Clinical trials
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spelling Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer ResearchPont, MarionaMarqués, MartaSorolla Bardají, Maria AlbaParisi, EvaUrdanibia, IzaskunMorales, SerafínSalud Salvia, Maria AntonietaSorolla Bardají, AnabelBreast cancerTriple negative breast cancerCRISPRApplicationsClinical trialsClustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology has transformed oncology research in many ways. Breast cancer is the most prevalent malignancy globally and triple negative breast cancer (TNBC) is one of the most aggressive subtypes with numerous challenges still to be faced. In this work, we have explained what CRISPR consists of and listed its applications in breast cancer while focusing on TNBC research. These are disease modelling, the search for novel genes involved in tumour progression, sensitivity to drugs and immunotherapy response, tumour fitness, diagnosis, and treatment. Additionally, we have listed the current delivery methods employed for the delivery of CRISPR systems in vivo. Lastly, we have highlighted the limitations that CRISPR technology is subject to and the future directions that we envisage. Overall, we have provided a round summary of the aspects concerning CRISPR in breast cancer/TNBC research.This work is funded by the Instituto de Salud Carlos III (Spanish Health Ministry) with a Miguel Servet fellowship (CP20/00039) and the project PI21/00438 which are co-funded by the European Social Fund (ESF) “Investing in your future” and the European Union. M.P. holds a PhD fellowship from the Instituto de Salud Carlos III (FI22/00012). M.M. is supported by a PhD fellowship from the Agency for Management of University and Research Grants of Catalonia, Spain (AGAUR) (2022 FI_B 00034). This research was supported by the CERCA Programme of Generalitat de Catalunya and the IRBLleida—Fundació Dr. Pifarré.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/cancers15174364https://hdl.handle.net/10459.1/464128reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.3390/cancers15174364Cancers, 2023, vol. 15, núm. 17, 4364cc-by (c) Mariona Pont et al., 2023Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4641282026-06-24T12:42:17Z
dc.title.none.fl_str_mv Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
title Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
spellingShingle Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
Pont, Mariona
Breast cancer
Triple negative breast cancer
CRISPR
Applications
Clinical trials
title_short Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
title_full Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
title_fullStr Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
title_full_unstemmed Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
title_sort Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
dc.creator.none.fl_str_mv Pont, Mariona
Marqués, Marta
Sorolla Bardají, Maria Alba
Parisi, Eva
Urdanibia, Izaskun
Morales, Serafín
Salud Salvia, Maria Antonieta
Sorolla Bardají, Anabel
author Pont, Mariona
author_facet Pont, Mariona
Marqués, Marta
Sorolla Bardají, Maria Alba
Parisi, Eva
Urdanibia, Izaskun
Morales, Serafín
Salud Salvia, Maria Antonieta
Sorolla Bardají, Anabel
author_role author
author2 Marqués, Marta
Sorolla Bardají, Maria Alba
Parisi, Eva
Urdanibia, Izaskun
Morales, Serafín
Salud Salvia, Maria Antonieta
Sorolla Bardají, Anabel
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Breast cancer
Triple negative breast cancer
CRISPR
Applications
Clinical trials
topic Breast cancer
Triple negative breast cancer
CRISPR
Applications
Clinical trials
description Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology has transformed oncology research in many ways. Breast cancer is the most prevalent malignancy globally and triple negative breast cancer (TNBC) is one of the most aggressive subtypes with numerous challenges still to be faced. In this work, we have explained what CRISPR consists of and listed its applications in breast cancer while focusing on TNBC research. These are disease modelling, the search for novel genes involved in tumour progression, sensitivity to drugs and immunotherapy response, tumour fitness, diagnosis, and treatment. Additionally, we have listed the current delivery methods employed for the delivery of CRISPR systems in vivo. Lastly, we have highlighted the limitations that CRISPR technology is subject to and the future directions that we envisage. Overall, we have provided a round summary of the aspects concerning CRISPR in breast cancer/TNBC research.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/cancers15174364
https://hdl.handle.net/10459.1/464128
url https://doi.org/10.3390/cancers15174364
https://hdl.handle.net/10459.1/464128
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/cancers15174364
Cancers, 2023, vol. 15, núm. 17, 4364
dc.rights.none.fl_str_mv cc-by (c) Mariona Pont et al., 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Mariona Pont et al., 2023
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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