Targeting the Src N-terminal regulatory element in cancer

We acknowledge extensive discussions with present and former members of the Pons’ group and the sustained collaboration with Serge Roche’s group in Montpellier. The Pons’ lab is financed by the Spanish Ministry of Science and Innovation (PID2019-104914RB-I00; PDC2021-121629-I00). The collaboration w...

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Detalles Bibliográficos
Autores: Mezquita, Betlem, Reyes-Farias, Marjorie, Pons, Miquel
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3717
Acceso en línea:http://hdl.handle.net/20.500.12328/3717
https://dx.doi.org/10.18632/oncotarget.28434
Access Level:acceso abierto
Palabra clave:Src quinases de la família
Proteïnes intrínsecament desordenades
SNRE
Fàrmacs selectius de tipus cel·lular
Resistència als fàrmacs
Src quinasas de la familia
Proteínas intrínsecamente desordenadas
Fármacos selectivos de tipo celular
Resistencia a las drogas
Src family kinases
Intrinsically disordered proteins
Cell-type selective drugs
Drug resistance
61
616
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repository_id_str
spelling Targeting the Src N-terminal regulatory element in cancerMezquita, BetlemReyes-Farias, MarjoriePons, MiquelSrc quinases de la famíliaProteïnes intrínsecament desordenadesSNREFàrmacs selectius de tipus cel·lularResistència als fàrmacsSrc quinasas de la familiaProteínas intrínsecamente desordenadasSNREFármacos selectivos de tipo celularResistencia a las drogasSrc family kinasesIntrinsically disordered proteinsSNRECell-type selective drugsDrug resistance61616We acknowledge extensive discussions with present and former members of the Pons’ group and the sustained collaboration with Serge Roche’s group in Montpellier. The Pons’ lab is financed by the Spanish Ministry of Science and Innovation (PID2019-104914RB-I00; PDC2021-121629-I00). The collaboration with the Roche group is financed by the French Agence Nationale de la Recherche (FUZZY-SRC ANR-21-CE13-0011).The signaling pathways displayed by cancer cells are often composed by the same components than the physiological ones, yet the overall result is a pathological deregulation. The non-receptor protein tyrosine kinase Src is a good example. Src is the first described proto-oncogene and a demonstrated player in cancer progression, as it affects proliferation, invasion, survival, cancer stemness, and drug resistance. Src activation is linked to poor prognosis in many cancer types, yet mutations in this protein are rarely observed. In addition, being a demonstrated cancer target, unspecific inhibition of the kinase activity has proven inefficient in clinics since the inhibition of Src in non-cancerous cells results in unacceptable toxicity. Thus, there is a need for new target regions in Src that could inhibit Src activity only in certain cell types, e.g., cancer cells, while maintaining the normal physiological activity in healthy cells. The Src N-terminal regulatory element (SNRE) includes the poorly studied intrinsically disordered region with unique sequences for each of the members of the Src family. In this perspective, we discuss the non-canonical regulatory mechanisms involving the SNRE and their potential use as oncotargets.info:eu-repo/semantics/publishedVersionImpact Journals2023info:eu-repo/semantics/article11http://hdl.handle.net/20.500.12328/3717https://dx.doi.org/10.18632/oncotarget.28434reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésOncotarget14https://www.oncotarget.com/article/28434/text/info:eu-repo/grantAgreement/ES/MICINN/PID2019-104914RB-I00info:eu-repo/grantAgreement/ES/MICINN/PDC2021-121629-I00© 2023 Mezquita et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.https://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/37172026-05-29T05:05:01Z
dc.title.none.fl_str_mv Targeting the Src N-terminal regulatory element in cancer
title Targeting the Src N-terminal regulatory element in cancer
spellingShingle Targeting the Src N-terminal regulatory element in cancer
Mezquita, Betlem
Src quinases de la família
Proteïnes intrínsecament desordenades
SNRE
Fàrmacs selectius de tipus cel·lular
Resistència als fàrmacs
Src quinasas de la familia
Proteínas intrínsecamente desordenadas
SNRE
Fármacos selectivos de tipo celular
Resistencia a las drogas
Src family kinases
Intrinsically disordered proteins
SNRE
Cell-type selective drugs
Drug resistance
61
616
title_short Targeting the Src N-terminal regulatory element in cancer
title_full Targeting the Src N-terminal regulatory element in cancer
title_fullStr Targeting the Src N-terminal regulatory element in cancer
title_full_unstemmed Targeting the Src N-terminal regulatory element in cancer
title_sort Targeting the Src N-terminal regulatory element in cancer
dc.creator.none.fl_str_mv Mezquita, Betlem
Reyes-Farias, Marjorie
Pons, Miquel
author Mezquita, Betlem
author_facet Mezquita, Betlem
Reyes-Farias, Marjorie
Pons, Miquel
author_role author
author2 Reyes-Farias, Marjorie
Pons, Miquel
author2_role author
author
dc.subject.none.fl_str_mv Src quinases de la família
Proteïnes intrínsecament desordenades
SNRE
Fàrmacs selectius de tipus cel·lular
Resistència als fàrmacs
Src quinasas de la familia
Proteínas intrínsecamente desordenadas
SNRE
Fármacos selectivos de tipo celular
Resistencia a las drogas
Src family kinases
Intrinsically disordered proteins
SNRE
Cell-type selective drugs
Drug resistance
61
616
topic Src quinases de la família
Proteïnes intrínsecament desordenades
SNRE
Fàrmacs selectius de tipus cel·lular
Resistència als fàrmacs
Src quinasas de la familia
Proteínas intrínsecamente desordenadas
SNRE
Fármacos selectivos de tipo celular
Resistencia a las drogas
Src family kinases
Intrinsically disordered proteins
SNRE
Cell-type selective drugs
Drug resistance
61
616
description We acknowledge extensive discussions with present and former members of the Pons’ group and the sustained collaboration with Serge Roche’s group in Montpellier. The Pons’ lab is financed by the Spanish Ministry of Science and Innovation (PID2019-104914RB-I00; PDC2021-121629-I00). The collaboration with the Roche group is financed by the French Agence Nationale de la Recherche (FUZZY-SRC ANR-21-CE13-0011).
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3717
https://dx.doi.org/10.18632/oncotarget.28434
url http://hdl.handle.net/20.500.12328/3717
https://dx.doi.org/10.18632/oncotarget.28434
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Oncotarget
14
https://www.oncotarget.com/article/28434/text/
info:eu-repo/grantAgreement/ES/MICINN/PID2019-104914RB-I00
info:eu-repo/grantAgreement/ES/MICINN/PDC2021-121629-I00
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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