Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs

MicroRNAs (miRNAs) are noncoding RNAs involved in post-transcriptional genetic regulation with a proposed role in intercellular communication. miRNAs are considered promising biomarkers in ischemic heart disease. Invasive physiological evaluation allows a precise assessment of each affected coronary...

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Autores: Matute-Blanco, Lucía, Fernández-Rodríguez, Diego, Casanova-Sandoval, Juan, Belmonte, Thalia, Benítez, Iván D., Rivera, Kristian, Garcia-Guimaraes, Marcos, Peral Disdier, Vicente, Cortés Villar, Carlos, Millán Segovia, Raúl, Barriuso, Ignacio, de Gonzalo-Calvo, David, Barbé, Ferran, Worner, Fernando
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/18989
Acceso en línea:https://hdl.handle.net/20.500.13003/18989
Access Level:acceso abierto
Palabra clave:Fractional Flow Reserve, Myocardial
Angina Pectoris
Coronary Stenosis
Coronary Angiography
Predictive Value of Tests
MicroRNAs
Humans
Coronary Artery Disease
Microcirculation
Vascular Resistance
Coronary Vessels
Epigenesis, Genetic
Epigénesis Genética
Vasos Coronarios
Estenosis Coronaria
Humanos
Valor Predictivo de las Pruebas
Resistencia Vascular
Enfermedad de la Arteria Coronaria
Microcirculación
Angina de Pecho
Reserva del Flujo Fraccional Miocárdico
Angiografía Coronaria
MicroARNs
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spelling Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAsMatute-Blanco, LucíaFernández-Rodríguez, DiegoCasanova-Sandoval, JuanBelmonte, ThaliaBenítez, Iván D.Rivera, KristianGarcia-Guimaraes, MarcosPeral Disdier, VicenteCortés Villar, CarlosMillán Segovia, RaúlBarriuso, Ignaciode Gonzalo-Calvo, DavidBarbé, FerranWorner, FernandoFractional Flow Reserve, MyocardialAngina PectorisCoronary StenosisCoronary AngiographyPredictive Value of TestsMicroRNAsHumansCoronary Artery DiseaseMicrocirculationVascular ResistanceCoronary VesselsEpigenesis, GeneticEpigénesis GenéticaVasos CoronariosEstenosis CoronariaHumanosValor Predictivo de las PruebasResistencia VascularEnfermedad de la Arteria CoronariaMicrocirculaciónAngina de PechoReserva del Flujo Fraccional MiocárdicoAngiografía CoronariaMicroARNsMicroRNAs (miRNAs) are noncoding RNAs involved in post-transcriptional genetic regulation with a proposed role in intercellular communication. miRNAs are considered promising biomarkers in ischemic heart disease. Invasive physiological evaluation allows a precise assessment of each affected coronary compartment. Although some studies have associated the expression of circulating miRNAs with invasive physiological indexes, their global relationship with coronary compartments has not been assessed. Here, we will evaluate circulating miRNAs profiles according to the coronary pattern of the vascular compartment affectation. This is an investigator-initiated, multicentre, descriptive study to be conducted at three centres in Spain (NCT05374694). The study will include one hundred consecutive patients older than 18 years with chest pain of presumed coronary cause undergoing invasive physiological evaluation, including fractional flow reserve (FFR) and index of microvascular resistance (IMR). Patients will be initially classified into four groups, according to FFR and IMR: macrovascular and microvascular affectation (FFR≤0.80 / IMR≥25), isolated macrovascular affectation (FFR≤0.80 / IMR<25), isolated microvascular affectation (FFR>0.80 / IMR ≥25) and normal coronary indexes (FFR>0.80 / IMR<25). Patients with isolated microvascular affectation or normal indexes will also undergo the acetylcholine test and may be reclassified as a fifth group in the presence of spasm. A panel of miRNAs previously associated with molecular mechanisms linked to chronic coronary syndrome will be analysed using RT-qPCR. The results of this study will identify miRNA profiles associated with patterns of coronary affectation and will contribute to a better understanding of the mechanistic pathways of coronary pathology.20232023-01-0120232023-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/18989reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/189892026-06-22T12:44:07Z
dc.title.none.fl_str_mv Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs
title Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs
spellingShingle Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs
Matute-Blanco, Lucía
Fractional Flow Reserve, Myocardial
Angina Pectoris
Coronary Stenosis
Coronary Angiography
Predictive Value of Tests
MicroRNAs
Humans
Coronary Artery Disease
Microcirculation
Vascular Resistance
Coronary Vessels
Epigenesis, Genetic
Epigénesis Genética
Vasos Coronarios
Estenosis Coronaria
Humanos
Valor Predictivo de las Pruebas
Resistencia Vascular
Enfermedad de la Arteria Coronaria
Microcirculación
Angina de Pecho
Reserva del Flujo Fraccional Miocárdico
Angiografía Coronaria
MicroARNs
title_short Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs
title_full Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs
title_fullStr Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs
title_full_unstemmed Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs
title_sort Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs
dc.creator.none.fl_str_mv Matute-Blanco, Lucía
Fernández-Rodríguez, Diego
Casanova-Sandoval, Juan
Belmonte, Thalia
Benítez, Iván D.
Rivera, Kristian
Garcia-Guimaraes, Marcos
Peral Disdier, Vicente
Cortés Villar, Carlos
Millán Segovia, Raúl
Barriuso, Ignacio
de Gonzalo-Calvo, David
Barbé, Ferran
Worner, Fernando
author Matute-Blanco, Lucía
author_facet Matute-Blanco, Lucía
Fernández-Rodríguez, Diego
Casanova-Sandoval, Juan
Belmonte, Thalia
Benítez, Iván D.
Rivera, Kristian
Garcia-Guimaraes, Marcos
Peral Disdier, Vicente
Cortés Villar, Carlos
Millán Segovia, Raúl
Barriuso, Ignacio
de Gonzalo-Calvo, David
Barbé, Ferran
Worner, Fernando
author_role author
author2 Fernández-Rodríguez, Diego
Casanova-Sandoval, Juan
Belmonte, Thalia
Benítez, Iván D.
Rivera, Kristian
Garcia-Guimaraes, Marcos
Peral Disdier, Vicente
Cortés Villar, Carlos
Millán Segovia, Raúl
Barriuso, Ignacio
de Gonzalo-Calvo, David
Barbé, Ferran
Worner, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Fractional Flow Reserve, Myocardial
Angina Pectoris
Coronary Stenosis
Coronary Angiography
Predictive Value of Tests
MicroRNAs
Humans
Coronary Artery Disease
Microcirculation
Vascular Resistance
Coronary Vessels
Epigenesis, Genetic
Epigénesis Genética
Vasos Coronarios
Estenosis Coronaria
Humanos
Valor Predictivo de las Pruebas
Resistencia Vascular
Enfermedad de la Arteria Coronaria
Microcirculación
Angina de Pecho
Reserva del Flujo Fraccional Miocárdico
Angiografía Coronaria
MicroARNs
topic Fractional Flow Reserve, Myocardial
Angina Pectoris
Coronary Stenosis
Coronary Angiography
Predictive Value of Tests
MicroRNAs
Humans
Coronary Artery Disease
Microcirculation
Vascular Resistance
Coronary Vessels
Epigenesis, Genetic
Epigénesis Genética
Vasos Coronarios
Estenosis Coronaria
Humanos
Valor Predictivo de las Pruebas
Resistencia Vascular
Enfermedad de la Arteria Coronaria
Microcirculación
Angina de Pecho
Reserva del Flujo Fraccional Miocárdico
Angiografía Coronaria
MicroARNs
description MicroRNAs (miRNAs) are noncoding RNAs involved in post-transcriptional genetic regulation with a proposed role in intercellular communication. miRNAs are considered promising biomarkers in ischemic heart disease. Invasive physiological evaluation allows a precise assessment of each affected coronary compartment. Although some studies have associated the expression of circulating miRNAs with invasive physiological indexes, their global relationship with coronary compartments has not been assessed. Here, we will evaluate circulating miRNAs profiles according to the coronary pattern of the vascular compartment affectation. This is an investigator-initiated, multicentre, descriptive study to be conducted at three centres in Spain (NCT05374694). The study will include one hundred consecutive patients older than 18 years with chest pain of presumed coronary cause undergoing invasive physiological evaluation, including fractional flow reserve (FFR) and index of microvascular resistance (IMR). Patients will be initially classified into four groups, according to FFR and IMR: macrovascular and microvascular affectation (FFR≤0.80 / IMR≥25), isolated macrovascular affectation (FFR≤0.80 / IMR<25), isolated microvascular affectation (FFR>0.80 / IMR ≥25) and normal coronary indexes (FFR>0.80 / IMR<25). Patients with isolated microvascular affectation or normal indexes will also undergo the acetylcholine test and may be reclassified as a fifth group in the presence of spasm. A panel of miRNAs previously associated with molecular mechanisms linked to chronic coronary syndrome will be analysed using RT-qPCR. The results of this study will identify miRNA profiles associated with patterns of coronary affectation and will contribute to a better understanding of the mechanistic pathways of coronary pathology.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/18989
url https://hdl.handle.net/20.500.13003/18989
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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