Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs

MicroRNAs (miRNAs) are noncoding RNAs involved in post-transcriptional genetic regulation with a proposed role in intercellular communication. miRNAs are considered promising biomarkers in ischemic heart disease. Invasive physiological evaluation allows a precise assessment of each affected coronary...

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Detalles Bibliográficos
Autores: Matute-Blanco, Lucía, Fernández-Rodríguez, Diego, Casanova-Sandoval, Juan, Belmonte, Thalia, Benítez, Iván D., Rivera, Kristian, Garcia-Guimaraes, Marcos, Peral Disdier, Vicente, Cortés Villar, Carlos, Millán Segovia, Raúl, Barriuso, Ignacio, de Gonzalo-Calvo, David, Barbé, Ferran, Worner, Fernando
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/18989
Acceso en línea:https://hdl.handle.net/20.500.13003/18989
Access Level:acceso abierto
Palabra clave:Fractional Flow Reserve, Myocardial
Angina Pectoris
Coronary Stenosis
Coronary Angiography
Predictive Value of Tests
MicroRNAs
Humans
Coronary Artery Disease
Microcirculation
Vascular Resistance
Coronary Vessels
Epigenesis, Genetic
Epigénesis Genética
Vasos Coronarios
Estenosis Coronaria
Humanos
Valor Predictivo de las Pruebas
Resistencia Vascular
Enfermedad de la Arteria Coronaria
Microcirculación
Angina de Pecho
Reserva del Flujo Fraccional Miocárdico
Angiografía Coronaria
MicroARNs
Descripción
Sumario:MicroRNAs (miRNAs) are noncoding RNAs involved in post-transcriptional genetic regulation with a proposed role in intercellular communication. miRNAs are considered promising biomarkers in ischemic heart disease. Invasive physiological evaluation allows a precise assessment of each affected coronary compartment. Although some studies have associated the expression of circulating miRNAs with invasive physiological indexes, their global relationship with coronary compartments has not been assessed. Here, we will evaluate circulating miRNAs profiles according to the coronary pattern of the vascular compartment affectation. This is an investigator-initiated, multicentre, descriptive study to be conducted at three centres in Spain (NCT05374694). The study will include one hundred consecutive patients older than 18 years with chest pain of presumed coronary cause undergoing invasive physiological evaluation, including fractional flow reserve (FFR) and index of microvascular resistance (IMR). Patients will be initially classified into four groups, according to FFR and IMR: macrovascular and microvascular affectation (FFR≤0.80 / IMR≥25), isolated macrovascular affectation (FFR≤0.80 / IMR<25), isolated microvascular affectation (FFR>0.80 / IMR ≥25) and normal coronary indexes (FFR>0.80 / IMR<25). Patients with isolated microvascular affectation or normal indexes will also undergo the acetylcholine test and may be reclassified as a fifth group in the presence of spasm. A panel of miRNAs previously associated with molecular mechanisms linked to chronic coronary syndrome will be analysed using RT-qPCR. The results of this study will identify miRNA profiles associated with patterns of coronary affectation and will contribute to a better understanding of the mechanistic pathways of coronary pathology.

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