PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors

The development of multifunctional organic materials represents a vibrant area of research, with applications spanning from biosensing to drug delivery. This study shows the development of a multifunctional bioelectronic device suitable for prolonged temperature monitoring and drug delivery applicat...

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Detalhes bibliográficos
Autores: López Larrea, Naroa, Wustoni, Shofarul, Peñas Núñez, Mario Iván, Uribe, Johana, Domínguez Alfaro, Antonio, Gallastegui, Antonela, Inal, Sahika, Mecerreyes Molero, David
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/69793
Acesso em linha:http://hdl.handle.net/10810/69793
Access Level:acceso abierto
Palavra-chave:4D printing
drug delivery
hydrogels
multifunctionality
OECTs
PEDOT:PSS
PNIPAM
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spelling PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical TransistorsLópez Larrea, NaroaWustoni, ShofarulPeñas Núñez, Mario IvánUribe, JohanaDomínguez Alfaro, AntonioGallastegui, AntonelaInal, SahikaMecerreyes Molero, David4D printingdrug deliveryhydrogelsmultifunctionalityOECTsPEDOT:PSSPNIPAMThe development of multifunctional organic materials represents a vibrant area of research, with applications spanning from biosensing to drug delivery. This study shows the development of a multifunctional bioelectronic device suitable for prolonged temperature monitoring and drug delivery applications. The device relies on a conducting and thermo-responsive hydrogel made of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate) (PEDOT:PSS) and poly(N-isopropylacrylamide) (PNIPAM). This multifunctional hydrogel is 4D printable by Digital Light Processing (DLP) method and exhibits optimal biocompatibility. The hydrogel features a low critical solution temperature (LCST) ≈35 °C, above which its resistance changes dramatically due to the shrinkage it undergoes with temperature. The integration of PNIPAM/PEDOT hydrogel into an organic electrochemical transistor (OECT) as the gate electrode allows to generate a miniaturized bioelectronic device with a reversible response to temperature variations between 25 to 45 °C, along with high sensitivity of 0.05 °C−1. Furthermore, the PNIPAM/PEDOT hydrogel demonstrates its utility in drug delivery, achieving an Insulin-FITC release rate of 82 ± 4% at 37 °C, mimicking human body conditions. The hydrogel's functionality to store and release the insulin does not compromise its thermo-responsivity and the overall performance of the OECT. This multifunctional OECT opens new avenues for the development of customizable and personalized sensing and drug-delivery systems.This work was supported by the Marie Sklodowska-Curie Research and Innovation Staff Exchanges (RISE) under grant agreement No. 823989 “IONBIKE”. Naroa Lopez-Larrea gratefully acknowledges the support from the Spanish Ministry of Universities (FPU20/03416).WileyEuropean Commission202420242024info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/69793reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/EC/H2020/823989https://onlinelibrary.wiley.com/doi/10.1002/adfm.202403708info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2024 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Atribución 3.0 Españaoai:addi.ehu.eus:10810/697932026-06-18T09:23:17Z
dc.title.none.fl_str_mv PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
spellingShingle PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
López Larrea, Naroa
4D printing
drug delivery
hydrogels
multifunctionality
OECTs
PEDOT:PSS
PNIPAM
title_short PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title_full PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title_fullStr PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title_full_unstemmed PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title_sort PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
dc.creator.none.fl_str_mv López Larrea, Naroa
Wustoni, Shofarul
Peñas Núñez, Mario Iván
Uribe, Johana
Domínguez Alfaro, Antonio
Gallastegui, Antonela
Inal, Sahika
Mecerreyes Molero, David
author López Larrea, Naroa
author_facet López Larrea, Naroa
Wustoni, Shofarul
Peñas Núñez, Mario Iván
Uribe, Johana
Domínguez Alfaro, Antonio
Gallastegui, Antonela
Inal, Sahika
Mecerreyes Molero, David
author_role author
author2 Wustoni, Shofarul
Peñas Núñez, Mario Iván
Uribe, Johana
Domínguez Alfaro, Antonio
Gallastegui, Antonela
Inal, Sahika
Mecerreyes Molero, David
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
dc.subject.none.fl_str_mv 4D printing
drug delivery
hydrogels
multifunctionality
OECTs
PEDOT:PSS
PNIPAM
topic 4D printing
drug delivery
hydrogels
multifunctionality
OECTs
PEDOT:PSS
PNIPAM
description The development of multifunctional organic materials represents a vibrant area of research, with applications spanning from biosensing to drug delivery. This study shows the development of a multifunctional bioelectronic device suitable for prolonged temperature monitoring and drug delivery applications. The device relies on a conducting and thermo-responsive hydrogel made of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate) (PEDOT:PSS) and poly(N-isopropylacrylamide) (PNIPAM). This multifunctional hydrogel is 4D printable by Digital Light Processing (DLP) method and exhibits optimal biocompatibility. The hydrogel features a low critical solution temperature (LCST) ≈35 °C, above which its resistance changes dramatically due to the shrinkage it undergoes with temperature. The integration of PNIPAM/PEDOT hydrogel into an organic electrochemical transistor (OECT) as the gate electrode allows to generate a miniaturized bioelectronic device with a reversible response to temperature variations between 25 to 45 °C, along with high sensitivity of 0.05 °C−1. Furthermore, the PNIPAM/PEDOT hydrogel demonstrates its utility in drug delivery, achieving an Insulin-FITC release rate of 82 ± 4% at 37 °C, mimicking human body conditions. The hydrogel's functionality to store and release the insulin does not compromise its thermo-responsivity and the overall performance of the OECT. This multifunctional OECT opens new avenues for the development of customizable and personalized sensing and drug-delivery systems.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/69793
url http://hdl.handle.net/10810/69793
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/EC/H2020/823989
https://onlinelibrary.wiley.com/doi/10.1002/adfm.202403708
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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